A. Gordon James

Graduate Student

University of Arkansas for Medical Sciences

grad_student

11 h-index 21 pubs 650 cited

Research Areas

Bone Metabolism and Diseases Mitochondrial Function and Pathology Autophagy and Lysosomal Biogenesis Aging Research Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies Health and Medical Research Impacts Gestational Diabetes Research and Management

Links

ORCID Lab Website

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OverviewAI-generated summary

A. Gordon James investigates the biological mechanisms underlying bone aging and strength, focusing on the role of autophagy and mitochondrial function in osteoblast lineage cells. His research has explored how genetic factors and cellular processes influence bone mass and mechanical properties over time.

James's work includes examining the impact of specific genes, such as Tfeb, a master regulator of autophagy, on bone health. He has also investigated the contribution of mitochondrial oxidative stress and reduced autophagy to age-related bone deterioration. His publications utilize advanced techniques, including single-cell RNA sequencing, to analyze cellular changes in bone during aging. James has a publication record of 21 papers with 650 citations and an h-index of 11, and collaborates with researchers at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 11
  • Publications: 21
  • Citations: 650

Selected Publications

  • The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025) DOI
  • Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength (2025) DOI
  • Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025) DOI
  • CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength (2024) DOI
  • Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice (2024) DOI
  • CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system (2023) DOI

Collaborators

Researchers in the database who share publications

Melda Onal University of Arkansas for Medical Sciences 5 shared publications Maria Almeida University of Arkansas for Medical Sciences 4 shared publications Jinhu Xiong University of Arkansas for Medical Sciences 3 shared publications Ilham Kadhim University of Arkansas for Medical Sciences 3 shared publications Julie Crawford University of Arkansas for Medical Sciences 3 shared publications James A. Hendrixson University of Arkansas for Medical Sciences 3 shared publications Amy Y. Sato University of Arkansas for Medical Sciences 2 shared publications Jeff Thostenson University of Arkansas for Medical Sciences 2 shared publications

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