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Biomedical Subjects
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Biography and Research Information
OverviewAI-generated summary
Claudia C.S. Chini's research focuses on the metabolism of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy production and signaling pathways. Her work investigates the roles of enzymes such as ADP-ribosyl cyclase 1 (CD38) and NAD+ nucleosidase in various physiological and pathological conditions, including aging, cardiac function, and reproductive health.
Her recent publications explore the implications of NAD+ metabolism in extending lifespan and healthspan in mouse models of aging, as well as its connection to spermatogenesis decline in aging mice. Chini's group has also examined the impact of CD38 suppression on cardiac function and exercise capacity, and the pro-inflammatory effects of dihydronicotinamide riboside, a NAD+ precursor, on macrophages. Furthermore, her research has identified the critical role of astrocyte NAD+ glycohydrolase in myelin injury and regeneration.
Chini leads a research group and has collaborated with researchers at the University of Arkansas for Medical Sciences, including Benjamin M. Stronach, Aaron Warren, Ha-Neui Kim, and Ana I. Coelho. Her scholarship metrics include an h-index of 29, with over 80 publications and 4,435 citations, reflecting her recognition as a highly cited researcher.
Metrics
- h-index: 29
- Publications: 80
- Citations: 4,435
Selected Publications
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Niacin (2026)
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Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts (2025)
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Chronic Cellular <scp>NAD</scp> Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial <scp>DNA</scp> Leakage (2025)
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Methylglyoxal Reshapes Hepatic and Adipose Tissue Metabolism and Increases Viability of Lymphocytes (2025)
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An NAD+-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging (2024)
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Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs (2023)
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Supplementary Figure 2 from Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors (2023)
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Supplementary Figure 4 from Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors (2023)
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Supplementary Figure 6 from Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors (2023)
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Supplementary Figure 3 from Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors (2023)
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Supplementary Figure Legend from Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors (2023)
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Supplementary Figure 1 from Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors (2023)
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supplementary figures from SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway (2023)
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supplementary figure legends from SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway (2023)
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Supplementary Figure 5 from Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors (2023)
Collaboration Network
Top Collaborators
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
- Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts
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