Aaron Warren

Research Associate III

University of Arkansas for Medical Sciences

postdoc

7 h-index 18 pubs 328 cited

Research Areas

Bone Metabolism and Diseases Mitochondrial Function and Pathology Diet and metabolism studies Genomics and Chromatin Dynamics Mesenchymal stem cell research

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OverviewAI-generated summary

Aaron Warren investigates the molecular mechanisms underlying age-related bone loss and skeletal development. His research focuses on the role of mitochondrial sirtuins, specifically Sirt3, in regulating bone resorption and osteoclast function. Warren's work has explored the contribution of NAD+ metabolism to the decline in osteoprogenitors and bone mass associated with aging and estrogen deficiency. He has also examined the impact of matrix metalloproteinase 13 (Mmp13) in mesenchymal cells on bone mass and the effects of estrogen deficiency. Furthermore, Warren has studied the necessity of the NAD salvage pathway in mesenchymal cells for proper skeletal development in mice and investigated the role of the hematopoietic cytoplasmic adaptor protein Hem1 in promoting osteoclast fusion and bone resorption. His recent work has utilized single-cell RNA sequencing to analyze mesenchymal lineage cells in mouse bone, aiming to understand the aging landscape of these cells.

Metrics

  • h-index: 7
  • Publications: 18
  • Citations: 328

Selected Publications

  • The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025) DOI
  • Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells (2025) DOI
  • The adverse effects of chemotherapy on bone mass are not prevented by senolytics (2025) DOI
  • Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells (2025) DOI
  • Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025) DOI
  • The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice (2023) DOI
  • Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022) DOI
  • Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency (2022) DOI
  • Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency (2022) DOI
  • Hem1 promotes osteoclast fusion and bone resorption in mice (2021) DOI
  • <i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice (2021) DOI
  • A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging (2021) DOI

Collaborators

Researchers in the database who share publications

Ha‐Neui Kim University of Arkansas for Medical Sciences 13 shared publications Maria Almeida University of Arkansas for Medical Sciences 12 shared publications Ana I. Coelho University of Arkansas for Medical Sciences 6 shared publications Stavros C. Manolagas University of Arkansas for Medical Sciences 5 shared publications Filipa Ponte University of Arkansas for Medical Sciences 5 shared publications Horacio Gómez-Acevedo University of Arkansas for Medical Sciences 4 shared publications Landon B. Gatrell University of Arkansas for Medical Sciences 4 shared publications Nükhet Aykin‐Burns University of Arkansas for Medical Sciences 4 shared publications

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Based on overlapping research topics

Landon Gatrell University of Arkansas for Medical Sciences
Bone Metabolism and Diseases Mitochondrial Function and Pathology Genomics and Chromatin Dynamics
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Rick D. Edmondson University of Arkansas for Medical Sciences
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