Sean H. Adams
Professor
Also affiliated: Rutgers, The State University of New Jersey (2015); Arkansas Children's Hospital (2015–2020); Pennsylvania State University (2015); Agricultural Research Service (2007–2020); United States Department of Agriculture (2010–2015); North Carolina State University (1995); University of Illinois Urbana-Champaign (1993–2015); University of South Africa (2016); South Dakota State University (2025); Urbana University (1996); University of California, Santa Cruz (1992–1994); University of Arkansas Medical Center (2016–2020); Royal Pharmaceutical Society (1978); West Health (2011–2014); Genesys (United States) (2000–2001); University of California System (2014); Western Human Nutrition Research Center (2007–2020); Health Sciences and Nutrition (2015); Nutrition 21 (United States) (2015–2016); Kaiser Permanente South San Francisco Medical Center (2000–2002); Children's Nutrition Research Center at Baylor College of Medicine (2015); XOMA (United States) (2015); Arkansas Children's Nutrition Center (2014–2021); PDL BioPharma (United States) (2004); Applied Natural Sciences (2016); University of California Davis Medical Center (2021–2025); UC Davis Health (2023); The University of Texas Medical Branch at Galveston (2015); Atotech (United States) (2001); Sunesis (United States) (2000–2006); Universitat de Barcelona (1997); University of California, Davis (2007–2025); The University of Texas Southwestern Medical Center (1998–2004)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Sean H. Adams' research investigates the physiological and molecular mechanisms underlying metabolic diseases, with a particular focus on obesity, diet, and their impact on various bodily systems. His work has explored sex differences in skeletal muscle, examining fiber type, capillarity, and transcriptomics in mouse models. Adams has also studied the effects of exercise and diet-induced weight loss on hepatic bile acid synthesis and serum concentrations in obese women, as well as how diet influences serum protein glycosylation in women at risk for cardiometabolic disease.
Further research by Adams has delved into the functions of myoglobin, considering its roles as a delivery vehicle for oxygen and fuels, a metabolic sensor, and its potential involvement in brown adipose tissue, utilizing myoglobin knockout mice. His investigations also encompass the assessment of insulin sensitivity and postprandial triglyceridemic responses using a mixed macronutrient tolerance test. Adams has contributed to studies on the effects of blueberry phytochemicals on cell models of inflammation and oxidative stress. His scholarly output includes over 230 publications, with an h-index of 48 and more than 11,500 citations, designating him as a highly cited researcher.
Metrics
- h-index: 48
- Publications: 231
- Citations: 11,803
Positions
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Professor publications 2007–2025University of California, Davis Department of Surgery, School of Medicine ORCID
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Professor publications 2015–2025University of Arkansas for Medical Sciences ORCID
Selected Publications
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Abstract 1547 Innovative Insights into Myoglobin-Metabolite Interactions and Muscle Cell Bioenergetics (2025)
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Cardiorespiratory Fitness Associates with Blood Pressure and Metabolic Health of Children—The Arkansas Active Kids Study (2021)
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Predictors of Platelet Mitochondria Respiration in Children – The Arkansas Active Kids Study (2021)
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Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice (2021)
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On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice (2021)
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Human Milk-Fed Piglets Have a Distinct Small Intestine and Circulatory Metabolome Profile Relative to That of Milk Formula-Fed Piglets (2021)
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Two SARS-CoV-2 Genome Sequences of Isolates from Rural U.S. Patients Harboring the D614G Mutation, Obtained Using Nanopore Sequencing (2021)
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Neonatal Diet Impacts the Large Intestine Luminal Metabolome at Weaning and Post-Weaning in Piglets Fed Formula or Human Milk (2020)
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Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity (2020)
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Impact of a weight loss and fitness intervention on exercise‐associated plasma oxylipin patterns in obese, insulin‐resistant, sedentary women (2020)
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Divergence in aerobic capacity impacts bile acid metabolism in young women (2020)
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Coupling of energy intake and energy expenditure across a temperature spectrum: impact of diet-induced obesity in mice (2020)
Collaboration Network
Top Collaborators
- Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Mice Fed a High-Fat Diet Supplemented with Resistant Starch Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Oxylipin Profiling of Alzheimer’s Disease in Nondiabetic and Type 2 Diabetic Elderly
Showing 5 of 13 shared publications
- Long-chain acylcarnitines activate cell stress and myokine release in C<sub>2</sub>C<sub>12</sub>myotubes: calcium-dependent and -independent effects
- Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C<sub>2</sub>C<sub>12</sub>myotubes
- Is palmitate truly proinflammatory? Experimental confounders and context-specificity
Showing 5 of 11 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Molecular Dynamic Simulations Reveal the Structural Determinants of Fatty Acid Binding to Oxy-Myoglobin
- Novel Molecular Interactions of Acylcarnitines and Fatty Acids with Myoglobin
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
Showing 5 of 11 shared publications
- Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C<sub>2</sub>C<sub>12</sub>myotubes
- Is palmitate truly proinflammatory? Experimental confounders and context-specificity
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice
Showing 5 of 8 shared publications
- Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats
- Impact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys
- Mice Fed a High-Fat Diet Supplemented with Resistant Starch Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria
- Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats
- Obese Mice Fed a Diet Supplemented with Enzyme-Treated Wheat Bran Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria
Showing 5 of 7 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
- Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model
- Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity
Showing 5 of 7 shared publications
- Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats
- Impact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys
- Mice Fed a High-Fat Diet Supplemented with Resistant Starch Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria
- Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats
- Obese Mice Fed a Diet Supplemented with Enzyme-Treated Wheat Bran Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria
Showing 5 of 6 shared publications
- Acylcarnitines as markers of exercise‐associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons
- Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention
- Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: application in rats and humans
- Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model
- Impact of a weight loss and fitness intervention on exercise‐associated plasma oxylipin patterns in obese, insulin‐resistant, sedentary women
Showing 5 of 6 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
- Neonatal Diet Impacts the Large Intestine Luminal Metabolome at Weaning and Post-Weaning in Piglets Fed Formula or Human Milk
- Human Milk-Fed Piglets Have a Distinct Small Intestine and Circulatory Metabolome Profile Relative to That of Milk Formula-Fed Piglets
Showing 5 of 6 shared publications
- Acylcarnitines as markers of exercise‐associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons
- A randomized controlled-feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indexes
- Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention
- Impact of a weight loss and fitness intervention on exercise‐associated plasma oxylipin patterns in obese, insulin‐resistant, sedentary women
- Metabolomics: applications in type 2 diabetes mellitus and insulin resistance
- Acylcarnitines—old actors auditioning for new roles in metabolic physiology
- Long-chain acylcarnitines activate cell stress and myokine release in C<sub>2</sub>C<sub>12</sub>myotubes: calcium-dependent and -independent effects
- Unique plasma metabolomic signatures of individuals with inherited disorders of long‐chain fatty acid oxidation
- Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders
- Evaluation of the Synuclein-γ (SNCG) Gene as a PPARγ Target in Murine Adipocytes, Dorsal Root Ganglia Somatosensory Neurons, and Human Adipose Tissue
- Molecular Dynamic Simulations Reveal the Structural Determinants of Fatty Acid Binding to Oxy-Myoglobin
- Novel Molecular Interactions of Acylcarnitines and Fatty Acids with Myoglobin
- Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin
- Binding energies and the entry route of palmitic acid and palmitoylcarnitine into myoglobin
- Abstract 1547 Innovative Insights into Myoglobin-Metabolite Interactions and Muscle Cell Bioenergetics
- Acylcarnitines as markers of exercise‐associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons
- Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention
- Impact of a weight loss and fitness intervention on exercise‐associated plasma oxylipin patterns in obese, insulin‐resistant, sedentary women
- Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation
- Limited Fatty Acid Oxidation (FAO) in CPT2 Knockout Myocytes Associates with Insulin Resistance and Cell Stress: possible role of acylcarnitine lipotoxicity
- Acylcarnitines as markers of exercise‐associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons
- A randomized controlled-feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indexes
- Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention
- Impact of a weight loss and fitness intervention on exercise‐associated plasma oxylipin patterns in obese, insulin‐resistant, sedentary women
- Challenges in Designing and Delivering Diets and Assessing Adherence: A Randomized Controlled Trial Evaluating the 2010 Dietary Guidelines for Americans
- Acylcarnitines as markers of exercise‐associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons
- A randomized controlled-feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indexes
- Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention
- Impact of a weight loss and fitness intervention on exercise‐associated plasma oxylipin patterns in obese, insulin‐resistant, sedentary women
- Challenges in Designing and Delivering Diets and Assessing Adherence: A Randomized Controlled Trial Evaluating the 2010 Dietary Guidelines for Americans
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