Valeriy V. Lyzogubov

High Impact

Researcher

UAMS primary UA Little Rock

Also affiliated: Pennington Biomedical Research Center (2006–2007); Louisiana State University System (2006–2007); Louisiana State University (2007); Morpho (United States) (2004–2012); Arkansas Cardiology (2007); Jones Institute (2008); R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (2005); Winthrop Rockefeller Foundation (2019–2021); Arkansas Department of Agriculture (2014–2015); Walker (United States) (2008)

Faculty Researcher

23 h-index 59 pubs 1,917 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

Valeriy V. Lyzogubov's research focuses on the mechanisms and potential therapeutic targets for age-related macular degeneration (AMD) and multiple myeloma. He has investigated the role of specific peptides, such as Adiponectin Peptide I (APNp1), in the development of AMD, and explored polyethylene glycol (PEG) as an inducer for both wet and dry forms of the disease in animal models. His work also extends to understanding the involvement of the complement system in ocular immune responses.

In addition to AMD, Lyzogubov has contributed to research on multiple myeloma, identifying PHF19 inhibition as a potential therapeutic strategy. His research utilizes various techniques, including immunohistochemistry, and involves animal models, primarily mice. Lyzogubov leads a research group and collaborates with several colleagues at the University of Arkansas for Medical Sciences, including Nalini S. Bora, Connor Logan, Reece Mitchell, and Samuel G. Mackintosh.

His scholarly output includes 59 publications with over 1,900 citations, reflected in an h-index of 23. He is recognized as a highly cited researcher, indicating a significant impact in his fields of study.

Metrics

h-index: 23
Publications: 59
Citations: 1,917

Selected Publications

Age-Related Macular Degeneration Models Induced by Polyethylene Glycol (PEG) (2024)

DOI OpenAlex
Role of Complement in the Ocular Immune Response (2024)

Elsevier eBooks DOI OpenAlex
Wet and Dry Age-Related Macular Degeneration Induced by Polyethylene Glycol (2023)

Preprints.org 3 citations DOI OpenAlex
Role of Adiponectin Peptide I (APNp1) in Age-Related Macular Degeneration (2022)

Biomolecules 11 citations DOI OpenAlex
PHF19 inhibition as a therapeutic target in multiple myeloma (2021)

Current Research in Translational Medicine 9 citations DOI OpenAlex
Role of thalidomide, senicapoc, and sodium butyrate in choroidal neovascularization (2020)

Biochemical and Biophysical Research Communications 7 citations DOI OpenAlex
Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns (2020)

Blood Cancer Journal 39 citations DOI OpenAlex
Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease (2020)

Leukemia 54 citations DOI OpenAlex
The Role of PHF19 As a Promoter of Tumorigenicity and Therapeutic Target in Multiple Myeloma (2019)

Blood DOI OpenAlex
Multiple Myeloma DREAM Challenge Reveals Epigenetic Regulator <i>PHF19</i> As Marker of Aggressive Disease (2019)

bioRxiv (Cold Spring Harbor Laboratory) 1 citation DOI OpenAlex
High Levels of APOBEC3B Gene Expression Contribute to Poor Prognosis in Multiple Myeloma Patients (2018)

Blood DOI OpenAlex
MAF and NF-κB Signaling Pathways Regulate Expression of APOBEC3B in Multiple Myeloma (2017)

Blood DOI OpenAlex
Effect of aspirin on models of retinal pigment epithelium pathology (2016)

Clinical and Experimental Ophthalmology 3 citations DOI OpenAlex
The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration–Like Phenotype (2016)

American Journal Of Pathology 48 citations DOI OpenAlex
In Vitro Assessment of Moxifloxacin Toxicity to Human Iris Pigment Epithelium (2015)

Investigative Ophthalmology & Visual Science 11 citations OpenAlex