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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-05
Christopher P. Wardell
High Impact
Assistant Professor
Also affiliated: University of Leeds (2011–2015); Institute of Cancer Research (2010–2023); University of Arkansas Medical Center (2019); Wessex Regional Genetics Laboratory (2011); RIKEN Center for Integrative Medical Sciences (2015–2018); University of Southampton (2011); Newcastle University (2011)
Biomedical Informatics, College of Medicine
37 h-index
164 pubs
7,874 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Christopher P. Wardell's research focuses on the molecular underpinnings of cancer, particularly multiple myeloma and glioblastoma. His work investigates the genomic and transcriptomic alterations that drive disease progression and influence patient outcomes. Wardell has explored the role of structural variants and specific gene mutations, such as those in the CRBN pathway, in the development of resistance to cancer therapies.
His research also encompasses the development and application of computational pipelines for precision medicine. This includes methods for analyzing next-generation sequencing data to identify actionable mutations and for combining transcriptomics with organoid modeling to tailor treatment strategies. Wardell collaborates with researchers at the University of Arkansas for Medical Sciences, including Michael Bauer, Cody Ashby, Michael Rutherford, and Murat Gökden, with whom he has co-authored multiple publications.
With an h-index of 37 and over 7,600 citations across 165 publications, Wardell is recognized as a highly cited researcher. His work contributes to understanding disease mechanisms and advancing therapeutic approaches in oncology.
Metrics
- h-index: 37
- Publications: 164
- Citations: 7,874
Positions
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Assistant Professor 2016–presentUniversity of Arkansas for Medical Sciences Biomedical Informatics, College of Medicine Institutional directory
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Bioinformatician 2014–2016RIKEN ORCID
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Bioinformatician 2009–2014Institute of Cancer Research ORCID
Selected Publications
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Longitudinal multi-omics characterization of the malignant evolution in multirelapsing glioblastoma (2026)
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Applying computational modelling to a high-risk multiple myeloma data set to create novel risk stratification groupings (2025)
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Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition (2025)
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Evaluating Skellytour for Automated Skeleton Segmentation from Whole-Body CT Images (2025)
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Long-read sequencing for brain tumors (2024)
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Abstract 953: Integration of functional precision medicine assay for high grade glioma management: A single institution experience (2024)
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Intracranial hematolymphoid malignancies: A case series with molecular characterization (2023)
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Science and Tools of Radiomics for Radiation Oncology (2023)
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An advanced molecular medicine case report of a rare human tumor using genomics, pathomics, and radiomics (2023)
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The Impact of Autologous Stem Cell Transplantation on the Genetics of High-Risk Relapsed Multiple Myeloma (2022)
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Identification of novel long noncoding RNA with distinct expression patterns in different subtypes of multiple myeloma (2022)
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Structural variants shape the genomic landscape and clinical outcome of multiple myeloma (2022)
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323 Generation of a functional precision medicine pipeline which combines comparative transcriptomics and tumor organoid modeling to identify bespoke treatment strategies for glioblastoma (2022)
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Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression (2022)
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A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma (2021)
Grants & Funding
As listed on this researcher's institutional profile.
- TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine NIH Co-Investigator
- TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine - Year 4 - Continuation NIH/Nat. Cancer Institute Co-Investigator
Collaboration Network
Top Collaborators
Brian A. Walker
Sylvester Comprehensive Cancer Center (US)
45 shared publications
- Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma
- A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
Showing 5 of 45 shared publications
Gareth J. Morgan
NYU Langone Health (US)
42 shared publications
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma
- Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
Showing 5 of 42 shared publications
Faith E. Davies
NYU Langone Health (US)
38 shared publications
- Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma
- A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
Showing 5 of 38 shared publications
Cody Ashby
University of Arkansas Medical Center
37 shared publications
In database
- Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma
- A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
Showing 5 of 37 shared publications
Michael Bauer
University of Arkansas for Medical Sciences
29 shared publications
In database
- Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma
- A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
Showing 5 of 29 shared publications
Frits van Rhee
Winthrop Rockefeller Foundation
21 shared publications
In database
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns
- An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome
Showing 5 of 21 shared publications
Carolina Schinke
Winthrop Rockefeller Foundation
20 shared publications
In database
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns
- An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome
Showing 5 of 20 shared publications
Niels Weinhold
Heidelberg University (DE)
19 shared publications
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
- Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs
- Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism
Showing 5 of 19 shared publications
Sharmilan Thanendrarajan
University of Arkansas for Medical Sciences
19 shared publications
In database
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns
- An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome
Showing 5 of 19 shared publications
Maurizio Zangari
Winthrop Rockefeller Foundation
18 shared publications
In database
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns
- An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome
Showing 5 of 18 shared publications
Eileen M. Boyle
NYU Langone Health (US)
16 shared publications
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma
- Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns
- Differential RNA splicing as a potentially important driver mechanism in multiple myeloma
- Daratumumab and dexamethasone is safe and effective for triple refractory myeloma patients: final results of the IFM 2014‐04 (Etoile du Nord) trial
Showing 5 of 16 shared publications
Graham Jackson
Newcastle University (GB)
15 shared publications
- The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma
- Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
- Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma
- Neutral tumor evolution in myeloma is associated with poor prognosis
- Search for rare protein altering variants influencing susceptibility to multiple myeloma
Showing 5 of 15 shared publications
Ruslana G. Tytarenko
University of Arkansas for Medical Sciences (US)
15 shared publications
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma
- Poor overall survival in hyperhaploid multiple myeloma is defined by double-hit bi-allelic inactivation of TP53
Showing 5 of 15 shared publications
Bart Barlogie
12 shared publications
In database
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns
- An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome
Showing 5 of 12 shared publications
Charlotte Pawlyn
Royal Marsden NHS Foundation Trust (GB)
11 shared publications
- Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
- HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target
- Neutral tumor evolution in myeloma is associated with poor prognosis
- Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs
- The genomic landscape of plasma cells in systemic light chain amyloidosis
Showing 5 of 11 shared publications
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