Kirk L. West

Post Doctoral Fellow

University of Arkansas for Medical Sciences

postdoc

9 h-index 28 pubs 326 cited

Research Areas

Cancer-related molecular mechanisms research DNA Repair Mechanisms Genomics and Chromatin Dynamics Protein Structure and Dynamics Molecular Biology Techniques and Applications

Links

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OverviewAI-generated summary

Kirk L. West's research focuses on molecular mechanisms underlying cellular responses to DNA damage and cancer. His work investigates the role of specific protein kinases, such as DYRK1A and Tousled-like kinases (TLK1 and TLK2), in regulating chromatin structure and repair processes following DNA damage. West has published research on how the autophosphorylation of TLK1 and TLK2 influences their recruitment to damaged chromatin, mediated by interactions with PCNA. Additionally, his publications explore the functional impact of genetic variations, such as rare single nucleotide polymorphisms (SNPs) in the HELB gene, on cellular functions including interactions with RPA. His research also examines the involvement of glycogen synthase kinase-3β in determining cancer cell sensitivity to PARP inhibitors by modulating 53BP1 function. West collaborates with researchers including Brian Koss, Sara Shalin, and Erin M. Taylor at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 9
  • Publications: 28
  • Citations: 326

Selected Publications

  • Rare SNP in the <i>HELB</i> gene interferes with RPA interaction and cellular function of HELB (2025) DOI
  • Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction (2024) DOI
  • Nuclear F-actin assembly on damaged chromatin is regulated by DYRK1A and Spir1 phosphorylation (2024) DOI
  • Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction (2024) DOI
  • Rare SNP in the <i>HELB</i> gene interferes with RPA interaction and cellular function of HELB (2024) DOI
  • Abstract PR011: Novel role of glycogen synthase kinase-3β in determining cancer cell response to PARPi through regulation of 53BP1 function (2024) DOI
  • 205 Targeting Homologous Repair to Overcome Genotoxic Therapy Resistance in Pancreatic Cancer (2022) DOI

Collaborators

Researchers in the database who share publications

Brian Koss University of Arkansas for Medical Sciences 4 shared publications Sara Shalin University of Arkansas for Medical Sciences 4 shared publications Erin M. Taylor University of Arkansas for Medical Sciences 4 shared publications Aaron J. Storey University of Arkansas for Medical Sciences 3 shared publications Maroof Zafar University of Arkansas for Medical Sciences 2 shared publications Eric J. Enemark University of Arkansas for Medical Sciences 2 shared publications Matthew D. Thompson Lyon College 2 shared publications Benjamin May University of Arkansas for Medical Sciences 2 shared publications

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