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Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
B
Brian Koss
Federal Grant PI
Assistant Professor
Also affiliated: Boston Children's Hospital (2013); La Jolla Institute for Immunology (2025); St. Jude Children's Research Hospital (2010–2019)
Faculty Researcher
Biochemistry & Molecular Biology, College of Medicine
17 h-index
77 pubs
2,017 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Brian Koss's research focuses on understanding the molecular mechanisms of cancer, particularly concerning cell survival, apoptosis, and the immune response within the tumor microenvironment. He has received significant federal funding for his work, including over $1.3 million from the NIH. His grants investigate T cell proteome dynamics to overcome the solid tumor microenvironment, leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells, and exploring the host GSK3β-53BP1 axis in immune control of solid tumor progression.
His recent publications explore diverse areas within cancer biology. These include the role of NEK2 in tumorigenesis, the regulation of 53BP1 at damaged chromatin, enhancer-activated RET in acute myeloid leukemia, and the suppression of S100b in melanoma cells using CRISPR/dCas9-KRAB to restore p53-mediated apoptosis. Additionally, his work has examined the impact of chemical inhibition of DNA-PKcs on T cell function, resveratrol's effects on MHC class I antigen presentation in melanoma, and proteomic analysis of T cell exhaustion.
Koss's scholarship metrics include an h-index of 17, with 77 total publications and nearly 2,000 citations. He actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Daniel Fil, Lora J. Rogers, Billie Heflin, and Jacob L. Edmondson, with whom he has co-authored numerous publications. He maintains an active lab website.
Metrics
- h-index: 17
- Publications: 77
- Citations: 2,017
Selected Publications
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Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy (2026)
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Abstract 5189: Generating EZH2-inhibitor resistant CAR-T cells to sustain function for combination therapy (2026)
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Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function (2026)
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DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling (2026)
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743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function (2025)
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)
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236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025)
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
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392 Donor-intrinsic proteomic programs shape CAR-T cell persistence across a longitudinal killing assay (2025)
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Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling (2025)
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DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells (2025)
Federal Grants 4 $1,988,099 total
NIH
Contact PI
Jul 2026 - Jun 2031
Targeting the E3 Ligase RNF166 to Prevent T-cell Exhaustion in Solid Tumors
NIH
Co-PI
May 2026 - Apr 2031
Exploring host GSK3β-53BP1 axis in immune control of solid tumor progression
NIH
Co-PI
Jun 2024 - May 2026
Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells
NIH
Contact PI
Sep 2021 - Aug 2026
Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironment
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes NIH/Nat. Cancer Institute Principal Investigator
- DNA-PKcs Regulation of LAT-Mediated Early TCR Signaling in CD4+ and CD8+ T Cells NIH Co-Principal Investigator
- Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes- Resubmission NIH Principal Investigator
- ABI B. Koss Startup FY26 Y5 State of Arkansas Principal Investigator
Collaboration Network
Top Collaborators
Daniel Fil
University of Arkansas for Medical Sciences
20 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
Showing 5 of 20 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
16 shared publications
In database
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 1892: Proteomic interrogation of the metabolic control of MHC class I antigen presentation in metastatic melanoma
Showing 5 of 16 shared publications
Sydnye L. Shuttleworth
University of Arkansas for Medical Sciences
16 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
Showing 5 of 16 shared publications
Lora J. Rogers
University of Arkansas for Medical Sciences
15 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- Abstract B015: Racial differences in epigenetic aging and its impact on expression of T-cell inhibitory receptors
Showing 5 of 15 shared publications
Jessica L Kelliher
University of Arkansas for Medical Sciences
11 shared publications
In database
- Evolved histone tail regulates 53BP1 recruitment at damaged chromatin
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
Showing 5 of 11 shared publications
Billie Heflin
University of Arkansas for Medical Sciences
10 shared publications
In database
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
Showing 5 of 10 shared publications
Jacob L Edmondson
University of Arkansas for Medical Sciences
10 shared publications
In database
- Role of NEK2 in tumorigenesis and tumor progression
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
Showing 5 of 10 shared publications
Katherine Wallis
University of Arkansas for Medical Sciences
9 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 9 shared publications
Michael Bauer
University of Arkansas for Medical Sciences
9 shared publications
In database
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract B015: Racial differences in epigenetic aging and its impact on expression of T-cell inhibitory receptors
- 255 Functional and multi-omic characterization of CAR T cells across healthy donors
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
Showing 5 of 9 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
9 shared publications
In database
- CAR-T Therapies in Solid Tumors: Opportunities and Challenges
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
Showing 5 of 9 shared publications
Lauren C. Morehead
University of Arkansas for Medical Sciences
7 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 6131: Harnessing resveratrol-mediated restoration of MHC-I in melanoma to enhance immunotherapy
Showing 5 of 7 shared publications
Aaron J. Storey
Arkana Laboratories
7 shared publications
In database
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
Showing 5 of 7 shared publications
Nathan L. Avaritt
University of Arkansas for Medical Sciences
5 shared publications
In database
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 1892: Proteomic interrogation of the metabolic control of MHC class I antigen presentation in metastatic melanoma
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 691 ATF6 activation promotes ICB response in melanoma
Lyle Burdine
University of Arkansas for Medical Sciences
5 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
- DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling
Zachary J. Waldrip
Arkansas Children's Hospital
5 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
- DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling
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