Match tier Listed
Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-08-08

Ryan Holdiness

Researcher

UAMS

Also affiliated: Lyon College (2026); University of Arkansas Community College at Batesville (2026)

Unknown Researcher

1 h-index 6 pubs 1 cited

Research Areas

Biomedical Subjects

  • Cell Culture Techniques, Three Dimensional
  • Fibroblasts
  • Myocardium
  • Epigenesis, Genetic
  • Epigenomics
  • Anti-Bacterial Agents
  • Rifamycins
  • Click Chemistry
  • Biomechanical Phenomena
  • Cells, Cultured
  • Extracellular Matrix
  • Female
  • Humans
  • Male
  • Diet, High-Fat

OverviewAI-generated summary

Ryan Holdiness researches the biological mechanisms underlying cardiometabolic diseases, focusing on fibroblast responses within three-dimensional microenvironments. His work investigates the interplay between biomechanics and epigenomics in atypical fibroblast behavior, particularly under nutritional stress simulating cardiometabolic conditions. Holdiness also explores the global transcriptional profiling of adipose tissue to uncover sex-dependent mechanisms in acute obesity and their implications for heart-adipose interorgan crosstalk. Additionally, his research includes a proteomics approach to identify mechanisms of anthracycline-induced cardiotoxicity in human cardiac fibroblasts. Holdiness has published work on late-stage functionalization of the rifamycin core via click chemistry, exploring new antibacterial derivatives.

Metrics

  • h-index: 1
  • Publications: 6
  • Citations: 1

Selected Publications

  • Sex-Specific Adipose Transcriptomic Reprogramming Drives Early Inter-Organ Remodeling in Heart and Liver Under Nutrient Excess (2026)
    Physiology DOI OpenAlex
  • 3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease (2025)
    American Journal of Physiology-Heart and Circulatory Physiology 1 citation DOI OpenAlex
  • Simulating Cardiometabolic Disease in a 3D-Microenvironment: Human Cardiac Fibroblast Response to Nutritional Stress (2025)
    Physiology DOI OpenAlex
  • Global Transcriptional Profiling of Adipose Tissue Uncovers Unique Sex-Dependent Mechanisms in Acute Obesity: Implications for Adipose-Heart Interorgan Crosstalk (2025)
    Physiology DOI OpenAlex
  • Proteomics Approach to Identify Anthracycline-induced Cardiotoxicity Mechanisms in Human Cardiac Fibroblasts (2024)
    Physiology DOI OpenAlex

View all publications on OpenAlex →

Collaboration Network

13 Collaborators 4 Institutions 1 Country

Top Collaborators

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