Xuan Zhang

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NCTR

Also affiliated: Inner Mongolia University for Nationalities (2021); Hebei Medical University (2007–2023); United States Food and Drug Administration (2008–2014); Ministry of Education of the People's Republic of China (2013); Anhui University (2014); Jimei University (2025); Shanxi University (2022); Zunyi Medical University (2025); Capital Medical University (2010–2023); Chinese Academy of Sciences (2014); Yichun University (2020–2021); Beijing Forestry University (2013–2015); Beijing Tian Tan Hospital (2010); Shanghai University of Traditional Chinese Medicine (2023); People's Liberation Army No. 150 Hospital (2015); Shanxi Province Hospital of Traditional Chinese Medicine (2022); Xi'an Medical University (2023); Hebei University of Chinese Medicine (2014–2025); First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (2012); Shanxi University of Traditional Chinese Medicine (2022); Seventh People's Hospital of Shanghai (2023); Jilin Agricultural University (2019); Chinese People's Liberation Army (2015); Beijing Chaoyang Emergency Medical Center (2023); Hebei University (2015); Inner Mongolia Medical University (2019–2020); China Agricultural University (2014–2025); The University of Texas Medical Branch at Galveston (2008); Universidad del Noreste (2025); Zhongkai University of Agriculture and Engineering (2025)

25 h-index 79 pubs 2,271 cited

Research Areas

Biomedical Subjects

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ORCID Research Group

OverviewAI-generated summary

Xuan Zhang's research focuses on understanding the mechanisms of toxicity and protective effects of various compounds, particularly in the context of cardiovascular and liver health. Zhang has investigated the role of specific ion channels, such as M-type K+ channels and Ca2+-activated Cl– channels, in the nociceptive signaling induced by bradykinin in rat sensory neurons. Further work has explored the protective mechanisms of natural compounds like tannic acid and crocin against drug-induced toxicities. Tannic acid has been studied for its protective effects on acute doxorubicin-induced cardiotoxicity and acetaminophen-induced hepatotoxicity in mice, involving the suppression of oxidative stress, inflammation, and apoptosis. Crocin has been examined for its ability to ameliorate arsenic trioxide-induced cardiotoxicity via the Keap1-Nrf2/HO-1 pathway and to attenuate isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling.

Additional research has examined the molecular underpinnings of toxicity and protection in plant cells, specifically investigating how hydrogen sulfide alleviates cadmium toxicity in Populus euphratica cells by regulating cadmium transport. The impact of natural flavonoids on transmembrane member 16A calcium-activated chloride channels, contributing to their anticancer effects, has also been a subject of study. Zhang's work also includes characterizing polysaccharides from Ganoderma lucidum for their hypolipidemic and antioxidant activities. With an h-index of 25 and over 2,200 citations across 79 publications, Zhang is recognized as a highly cited researcher.

Metrics

h-index: 25
Publications: 79
Citations: 2,271

Selected Publications

Biomarkers of Neurotoxicity and Disease (2025)

Elsevier eBooks 1 citation DOI OpenAlex
Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain (2023)

Experimental Biology and Medicine 4 citations DOI OpenAlex
Identifying Potential Biomarkers, Mechanisms and Protective Strategies for General Anesthetic‐Induced Neurotoxicity in the Developing Nonhuman Primate (2018)

The FASEB Journal DOI OpenAlex