Xinyu Li
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Research Areas
Biomedical Subjects
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Biography and Research Information
OverviewAI-generated summary
Xinyu Li's research focuses on understanding molecular mechanisms underlying disease, with a particular emphasis on cancer and tissue repair. Li has investigated the role of microRNAs in regulating angiogenesis and choroidal neovascularization, as well as their involvement in ovarian granulosa cell apoptosis through specific signaling pathways. This work includes studying the impact of microRNAs like miR-143 and miR-204 in hepatocellular carcinoma, where LncRNA NEAT1 promotes autophagy and enhances cell resistance to sorafenib.
Further research extends to the mechanisms of radiation-induced normal tissue damage, exploring oxidative stress and epigenetic factors. Li's work also encompasses the development and application of tissue engineering models, such as osteochondral tissue chips derived from induced pluripotent stem cells for modeling osteoarthritis and drug testing. The broader implications of cellular communication, including the role of exosomes in the tumor microenvironment, are also areas of investigation. Li has contributed to studies on the clinical course and mortality risk factors for COVID-19 patients with pre-existing cirrhosis and the physiological significance of amino acid metabolism in the liver.
Metrics
- h-index: 43
- Publications: 372
- Citations: 5,893
Selected Publications
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Expanding the Genetic Code with Lysine Aminoacylation (2026)
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Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655 (2026)
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Functional consequences of lysine acetylation of phosphofructokinase isozymes (2025)
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Characterizing lysine acetylation of glucokinase (2023)
Collaboration Network
Top Collaborators
- Characterizing lysine acetylation of glucokinase
- Functional consequences of lysine acetylation of phosphofructokinase isozymes
- Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655
- Expanding the Genetic Code with Lysine Aminoacylation
- Characterizing lysine acetylation of glucokinase
- Functional consequences of lysine acetylation of phosphofructokinase isozymes
- Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655
- Expanding the Genetic Code with Lysine Aminoacylation
- Characterizing lysine acetylation of glucokinase
- Functional consequences of lysine acetylation of phosphofructokinase isozymes
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