Match tier
Likely match
Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
Q
Qingsu Xia
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Role not yet determined Is this you? Add your title
Also affiliated: Center for Food Safety and Applied Nutrition (2005); United States Food and Drug Administration (1998–2024); Chinese University of Hong Kong (2004); National Institute of Environmental Health Sciences (2002); Instituto Superior Técnico (2010); Centro de Química Estrutural (2010); Universidade Técnica de Lisboa (2010)
35 h-index
97 pubs
5,534 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Qingsu Xia investigates the molecular mechanisms underlying the carcinogenicity of pyrrolizidine alkaloids (PAs) and their role in human liver cancer. His research focuses on the formation of DNA and protein adducts resulting from the metabolism of PAs, which are found in various plant species and can contaminate food and dietary supplements. Xia has published research detailing how these adducts contribute to tumor development, utilizing techniques such as mutational signature analysis and the development of non-invasive biomarkers in urine and blood for early detection of PA-induced liver injury.
His work also explores protective mechanisms against PA-induced hepatotoxicity. In collaboration with researchers such as Xiaobo He and Matthew Bryant at the National Center for Toxicological Research, Xia has investigated how compounds like liquorice extract can mitigate PA-induced liver damage by inhibiting the metabolic activation of PAs. This research involves studies in animal models, including rats and mice, to understand the correlation between specific adducts and tumorigenic risk. Xia's scholarship includes 98 publications with over 5,400 citations and an h-index of 35.
Metrics
- h-index: 35
- Publications: 97
- Citations: 5,534
Selected Publications
-
An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024)
-
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023)
-
Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid (2022)
-
Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation (2022)
-
Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloidN-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts (2021)
-
Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human (2021)
-
Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury (2021)
-
Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer (2021)
-
1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO–DHP)–Cysteine Conjugates: Metabolic Formation and Binding to Cellular DNA (2020)
-
Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes (2020)
-
Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis (2019)
-
1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids (2019)
-
1‐Formyl‐7‐hydroxy‐6,7‐dihydro‐5 H ‐pyrrolizine (9‐CHO‐DHP) ‐ A Biologically Proximate Pyrrolic Metabolite of Carcinogenic Pyrrolizidine Alkaloids (2018)
-
Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells (2018)
-
Pyrrole-protein adducts – A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity (2018)
Collaboration Network
Top Collaborators
Peter P. Fu
National Center for Toxicological Research (US)
85 shared publications
- Mechanisms of nanotoxicity: Generation of reactive oxygen species
- Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms
- Ginkgo BilobaLeave Extract: Biological, Medicinal, and Toxicological Effects
- Phototoxicity and Environmental Transformation of Polycyclic Aromatic Hydrocarbons (PAHs)—Light-Induced Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage
- Enzyme-Like Activity of Nanomaterials
Showing 5 of 85 shared publications
Ge Lin
Chinese University of Hong Kong (HK)
22 shared publications
- Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms
- Pyrrolizidine Alkaloid-Derived DNA Adducts as a Common Biological Biomarker of Pyrrolizidine Alkaloid-Induced Tumorigenicity
- Genotoxic Pyrrolizidine Alkaloids — Mechanisms Leading to DNA Adduct Formation and Tumorigenicity
- Pyrrole-protein adducts – A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity
- Quality Assurance and Safety of Herbal Dietary Supplements
Showing 5 of 22 shared publications
Xiaobo He
National Center for Toxicological Research
16 shared publications
In database
- 7-Glutathione Pyrrole Adduct: A Potential DNA Reactive Metabolite of Pyrrolizidine Alkaloids
- Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned withHeliotropium europaeum
- 7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids
- Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N -oxides
- Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation
Showing 5 of 16 shared publications
Hongtao Yu
Jackson State University (US)
15 shared publications
- Mechanisms of nanotoxicity: Generation of reactive oxygen species
- Phototoxicity and Environmental Transformation of Polycyclic Aromatic Hydrocarbons (PAHs)—Light-Induced Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage
- Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage
- Photodecomposition and Phototoxicity of Natural Retinoids
- Full Structure Assignments of Pyrrolizidine Alkaloid DNA Adducts and Mechanism of Tumor Initiation
Showing 5 of 15 shared publications
Yuewei Zhao
National Center for Toxicological Research (US)
13 shared publications
- Pyrrolizidine Alkaloid-Derived DNA Adducts as a Common Biological Biomarker of Pyrrolizidine Alkaloid-Induced Tumorigenicity
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
- Full Structure Assignments of Pyrrolizidine Alkaloid DNA Adducts and Mechanism of Tumor Initiation
- Pyrrolizidine Alkaloid-Protein Adducts: Potential Non-invasive Biomarkers of Pyrrolizidine Alkaloid-Induced Liver Toxicity and Exposure
- Photoirradiation of dehydropyrrolizidine alkaloids—Formation of reactive oxygen species and induction of lipid peroxidation
Showing 5 of 13 shared publications
Jun‐Jie Yin
Center for Food Safety and Applied Nutrition (US)
11 shared publications
- Enzyme-Like Activity of Nanomaterials
- Platinum Nanoparticles: Efficient and Stable Catechol Oxidase Mimetics
- UVA photoirradiation of benzo[ a ]pyrene metabolites: induction of cytotoxicity, reactive oxygen species, and lipid peroxidation
- Photoirradiation of azulene and guaiazulene—Formation of reactive oxygen species and induction of lipid peroxidation
- UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides †
Showing 5 of 11 shared publications
Wayne G. Wamer
Center for Food Safety and Applied Nutrition (US)
10 shared publications
- Enzyme-Like Activity of Nanomaterials
- Platinum Nanoparticles: Efficient and Stable Catechol Oxidase Mimetics
- Photodecomposition and Phototoxicity of Natural Retinoids
- UVA photoirradiation of retinyl palmitate—Formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation
- Photodecomposition of Retinyl Palmitate in Ethanol by UVA LightFormation of Photodecomposition Products, Reactive Oxygen Species, and Lipid Peroxides
Showing 5 of 10 shared publications
Ming Wu Chou
National Center for Toxicological Research (US)
10 shared publications
- Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms
- Genotoxic Pyrrolizidine Alkaloids — Mechanisms Leading to DNA Adduct Formation and Tumorigenicity
- Human Liver Microsomal Metabolism and DNA Adduct Formation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
- Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine
Showing 5 of 10 shared publications
Paul C. Howard
National Center for Toxicological Research
9 shared publications
In database
- Photodecomposition and Phototoxicity of Natural Retinoids
- UVA photoirradiation of retinyl palmitate—Formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation
- Photodecomposition of Retinyl Palmitate in Ethanol by UVA LightFormation of Photodecomposition Products, Reactive Oxygen Species, and Lipid Peroxides
- Photodecomposition of Vitamin A and Photobiological Implications for the Skin†
- Physiological Role of Retinyl Palmitate in the Skin
Showing 5 of 9 shared publications
Lining Cai
9 shared publications
- Platinum Nanoparticles: Efficient and Stable Catechol Oxidase Mimetics
- Pyrrolizidine Alkaloid-Derived DNA Adducts as a Common Biological Biomarker of Pyrrolizidine Alkaloid-Induced Tumorigenicity
- 7-Glutathione Pyrrole Adduct: A Potential DNA Reactive Metabolite of Pyrrolizidine Alkaloids
- Full Structure Assignments of Pyrrolizidine Alkaloid DNA Adducts and Mechanism of Tumor Initiation
- Pyrrolizidine Alkaloid-Protein Adducts: Potential Non-invasive Biomarkers of Pyrrolizidine Alkaloid-Induced Liver Toxicity and Exposure
Showing 5 of 9 shared publications
Linda S. Von Tungeln
National Center for Toxicological Research
8 shared publications
In database
- Pyrrolizidine Alkaloid-Derived DNA Adducts as a Common Biological Biomarker of Pyrrolizidine Alkaloid-Induced Tumorigenicity
- Liver tumors induced in B6C3F1 mice by 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene contain K-ras protooncogene mutations
- Neonatal Mouse Tumorigenicity Bioassay
- Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice
- Tumorigenicity and liver tumor ras-protooncogene mutations in CD-1 mice treated neonatally with 1- and 3-nitrobenzo[a]pyrene and their trans-7,8-dihydrodiol and aminobenzo[a]pyrene metabolites
Showing 5 of 8 shared publications
Mary D. Boudreau
National Center for Toxicological Research
7 shared publications
In database
- Photodecomposition and Phototoxicity of Natural Retinoids
- UVA photoirradiation of retinyl palmitate—Formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation
- Photodecomposition of Vitamin A and Photobiological Implications for the Skin†
- Physiological Role of Retinyl Palmitate in the Skin
- Photoirradiation of Retinyl Palmitate in Ethanol with Ultraviolet Light - Formation of Photodecomposition Products, Reactive Oxygen Species, and Lipid Peroxides
Showing 5 of 7 shared publications
Shu-Hui Cherng
National Center for Toxicological Research (US)
7 shared publications
- UVA photoirradiation of retinyl palmitate—Formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation
- Photodecomposition of Retinyl Palmitate in Ethanol by UVA LightFormation of Photodecomposition Products, Reactive Oxygen Species, and Lipid Peroxides
- Photodecomposition of Vitamin A and Photobiological Implications for the Skin†
- Photoirradiation of Retinyl Palmitate in Ethanol with Ultraviolet Light - Formation of Photodecomposition Products, Reactive Oxygen Species, and Lipid Peroxides
- Photo-induced DNA damage and photocytotoxicity of retinyl palmitate and its photodecomposition products
Showing 5 of 7 shared publications
Jian Yan
Jackson State University (US)
7 shared publications
- Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage
- Photodecomposition of Vitamin A and Photobiological Implications for the Skin†
- Identification of DNA Adducts Derived from Riddelliine, a Carcinogenic Pyrrolizidine Alkaloid
- Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine
- Photo-induced DNA damage and photocytotoxicity of retinyl palmitate and its photodecomposition products
Showing 5 of 7 shared publications
Liang Ma
National Center for Toxicological Research (US)
6 shared publications
- 7-Glutathione Pyrrole Adduct: A Potential DNA Reactive Metabolite of Pyrrolizidine Alkaloids
- 7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids
- Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation
- UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides †
- Synthesis and phototoxicity of isomeric 7,9-diglutathione pyrrole adducts: Formation of reactive oxygen species and induction of lipid peroxidation
Showing 5 of 6 shared publications
Similar Researchers
Based on overlapping research topics
Frederick A. Beland
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
DNA Adducts
Mackean P. Maisha
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Drug-Induced Hepatotoxicity and Protection
Cancer-related molecular mechanisms research
Michael Ward
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Liver Disease Diagnosis and Treatment
Cancer-related molecular mechanisms research
Ji‐Eun Seo
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Drug-Induced Hepatotoxicity and Protection
Cancer-related molecular mechanisms research
Xiaobo He
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Cancer-related molecular mechanisms research
Robert R. Delongchamp
University of Arkansas for Medical Sciences
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Cancer-related molecular mechanisms research