Qingsu Xia Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

35 h-index 98 pubs 5,356 cited

Research Areas

Carcinogens and Genotoxicity Assessment Drug-Induced Hepatotoxicity and Protection Metabolism and Genetic Disorders Liver Disease Diagnosis and Treatment Cancer-related molecular mechanisms research Pharmacological Effects and Toxicity Studies Biomarkers for Disease Diagnosis DNA Repair Mechanisms

Links

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OverviewAI-generated summary

Qingsu Xia investigates the metabolic activation of pyrrolizidine alkaloids (PAs) and their contribution to liver cancer. Research from Xia's laboratory has focused on identifying and characterizing DNA and protein adducts formed from PA metabolism, which are considered key indicators of PA-induced liver injury and tumorigenic risk. Studies have explored the use of urinary pyrrole-amino acid adducts as non-invasive biomarkers for detecting PA-induced liver damage in humans. Further work has examined the correlation between different types of adducts in animal models and the metabolic pathways involved in their formation, including the role of cytochrome P450 enzymes and liver microsomes. The research also investigates protective mechanisms against PA-induced hepatotoxicity, such as the role of liquorice extract and its components.

Metrics

  • h-index: 35
  • Publications: 98
  • Citations: 5,356

Selected Publications

  • An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024) DOI
  • Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023) DOI
  • Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid (2022) DOI
  • Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation (2022) DOI
  • Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts (2021) DOI
  • Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human (2021) DOI
  • Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury (2021) DOI
  • Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer (2021) DOI

Collaborators

Researchers in the database who share publications

Xiaobo He National Center for Toxicological Research 3 shared publications Matthew Bryant National Center for Toxicological Research 2 shared publications Qiang Shi National Center for Toxicological Research 1 shared publication Gonçalo Gamboa da Costa National Center for Toxicological Research 1 shared publication

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