Brian D. Piccolo
High Impact
Assistant Professor, Tenure Track
faculty
Peds Pediatrics, College of Medicine
24 h-index
89 pubs
1,823 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Brian D. Piccolo's research focuses on the interplay between diet, the gut microbiome, and metabolic health, particularly in the context of obesity and liver disease. His work utilizes animal models, including mice, pigs, and rats, to investigate how dietary components and interventions influence microbial composition, bile acid metabolism, and disease progression. He has explored the effects of specific diets, such as blueberry, olive oil, and coconut oil, on vascular complications in diabetes and liver injury in models of non-alcoholic fatty liver disease (NAFLD).
Further investigations by Piccolo examine how dietary manipulations, like iron deficiency or varying fat compositions, impact gut health and enteric infections. His research also extends to human studies, analyzing how diet and exercise affect the gut microbiome and circulating metabolites in adults. He has published on the associations between maternal diet, body composition, and offspring gut microbiome in the first year of life, highlighting the importance of early life nutrition.
Piccolo holds an Assistant Professor position in the Department of Pediatrics at the University of Arkansas for Medical Sciences. His scholarship metrics include an h-index of 24 and over 1,700 citations across 90 publications. He leads a research group and collaborates with several colleagues at his institution, including Sree V. Chintapalli, Renny S. Lan, Sean H. Adams, and Lindsay Pack.
Metrics
- h-index: 24
- Publications: 89
- Citations: 1,823
Selected Publications
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Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures (2025)
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Beyond the Known Metabolome: Predictive Strategies for Dark Matter Discovery (2025)
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Fueling the fire: colonocyte metabolism and its effect on the colonic epithelia (2025)
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Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues (2024)
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Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice (2024)
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Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats (2024)
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Physiological response to fetal intravenous lipid emulsion (2024)
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Parental cardiorespiratory fitness influences early life energetics and metabolic health (2023)
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Exercise training modifies xenometabolites in gut and circulation of lean and obese adults (2023)
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Olive- and Coconut-Oil-Enriched Diets Decreased Secondary Bile Acids and Regulated Metabolic and Transcriptomic Markers of Brain Injury in the Frontal Cortexes of NAFLD Pigs (2022)
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Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD (2022)
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C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice (2022)
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Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis (2022)
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Associations between maternal obesity and offspring gut microbiome in the first year of life (2022)
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Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI (2022)
Collaboration Network
Top Collaborators
Sree V. Chintapalli
University of Arkansas for Medical Sciences
8 shared publications
In database
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice
Showing 5 of 8 shared publications
Kartik Shankar
University of Arkansas for Medical Sciences (US)
8 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI
Showing 5 of 8 shared publications
Becky Moody
Arkansas Children's Nutrition Center (US)
7 shared publications
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
Showing 5 of 7 shared publications
Sean H. Adams
University of California, Davis
7 shared publications
In database
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Beyond Butyrate – Xenometabolomics Reveals Hundreds of Metabolites and Fiber Type-Specific Signatures in Human Stool Cultures
Showing 5 of 7 shared publications
Renny S. Lan
University of Arkansas for Medical Sciences
7 shared publications
In database
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- P20-038-23 Colonic Epithelia Hypoxia Remains Constant During the Progression of Diabetes in the UC Davis Type 2 Diabetes Mellitus Rat Model
Showing 5 of 7 shared publications
Meghan L. Ruebel
Agricultural Research Service (US)
5 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
- Heat Stress-Associated Growth Retardation in the First 1000 Days Is Mitigated by Preconception Nutritional Supplementation
- Feasibility of Using the UC Davis Type 2 Diabetes Mellitus Rat Model as a Preclinical Model of Gestational Glycemic Dysregulation
Aline Andres
University of Arkansas for Medical Sciences
5 shared publications
In database
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
- A Structured Exercise Intervention in Healthy Pregnant Women With Obesity Has Minimal Effect on the Gut Microbiome
- Prenatal Exercise Training Alters Plasma Metabolite Responses To Acute Exercise In Pregnant Women With Obesity
James L. Graham
University of California, Davis (US)
5 shared publications
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- P20-038-23 Colonic Epithelia Hypoxia Remains Constant During the Progression of Diabetes in the UC Davis Type 2 Diabetes Mellitus Rat Model
- Feasibility of Using the UC Davis Type 2 Diabetes Mellitus Rat Model as a Preclinical Model of Gestational Glycemic Dysregulation
- Increased Insulin Sensitivity in Diabetic UC Davis Type 2 Diabetes Mellitus Rats Upregulates the Protein Expression of Phd2 and Occludin
Peter J. Havel
University of California, Davis (US)
5 shared publications
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- P20-038-23 Colonic Epithelia Hypoxia Remains Constant During the Progression of Diabetes in the UC Davis Type 2 Diabetes Mellitus Rat Model
- Feasibility of Using the UC Davis Type 2 Diabetes Mellitus Rat Model as a Preclinical Model of Gestational Glycemic Dysregulation
- Increased Insulin Sensitivity in Diabetic UC Davis Type 2 Diabetes Mellitus Rats Upregulates the Protein Expression of Phd2 and Occludin
Lindsay Pack
Arkansas Children's Nutrition Center
5 shared publications
In database
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- P20-038-23 Colonic Epithelia Hypoxia Remains Constant During the Progression of Diabetes in the UC Davis Type 2 Diabetes Mellitus Rat Model
- Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures
Leslie Tabor‐Simecka
Arkansas Children's Nutrition Center (US)
5 shared publications
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- P20-038-23 Colonic Epithelia Hypoxia Remains Constant During the Progression of Diabetes in the UC Davis Type 2 Diabetes Mellitus Rat Model
- 469 Identification of gut barrier protective fruits and vegetables for Latin American infants
- A Structured Exercise Intervention in Healthy Pregnant Women With Obesity Has Minimal Effect on the Gut Microbiome
- Increased Insulin Sensitivity in Diabetic UC Davis Type 2 Diabetes Mellitus Rats Upregulates the Protein Expression of Phd2 and Occludin
Laxmi Yeruva
Arkansas Children's Nutrition Center (US)
4 shared publications
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
Michael S. Robeson
University of Arkansas for Medical Sciences
4 shared publications
In database
- Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Fueling the fire: colonocyte metabolism and its effect on the colonic epithelia
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
Stephanie P. Gilley
University of Colorado Denver (US)
3 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
Clark Sims
Arkansas Children's Hospital
3 shared publications
In database
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
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