Daniel E. Voth
Department Chairperson
Also affiliated: National Institutes of Health (2007–2009); Harvard University (2003); Johannes Gutenberg University Mainz (1965); National Institute of Allergy and Infectious Diseases (2007–2010); Rocky Mountain Research (United States) (2007); Arkansas Department of Agriculture (2011); University of Oklahoma Health Sciences Center (2005–2007); University of Oklahoma (2003–2004); Stanford University (2006)
Faculty Researcher
Department Chairs, College of Medicine
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Daniel E. Voth's research program investigates host-pathogen interactions, with a particular focus on the obligate intracellular bacterium *Coxiella burnetii*, the causative agent of Q fever. His work explores how this bacterium manipulates host cell processes, such as macrophage metabolism and antioxidant signaling, to establish infection. He has received significant federal funding from the National Institutes of Health (NIH) for this research, including grants aimed at understanding *Coxiella burnetii*'s subversion of host immunity and the impact of host-directed drugs on bacterial growth.
Beyond *Coxiella burnetii*, Voth's laboratory also develops and validates models for studying other bacterial pathogens, including work on genetic manipulation of *Borrelia duttonii*. His group utilizes diverse infection models, encompassing in vitro cell cultures, in vivo animal models, and ex vivo lung tissue systems, to comprehensively study pathogen invasion and host defense mechanisms. His recent publications highlight investigations into metabolic regulation of lung macrophages, the role of microRNAs in host response, and the potential of targeting neurotransmitter systems to combat bacterial infections. Voth is also involved in establishing broader research infrastructure, having served as PI on a large NIH grant to create a Center for Animal Models of Infection and Disease at UAMS.
With an h-index of 31 and over 21,000 citations, Voth is recognized as a highly cited researcher. He has authored 77 publications and maintains an active laboratory website. His collaborations within the University of Arkansas for Medical Sciences involve researchers such as Amanda L. Dragan, Marissa S. Fullerton, and Katelynn R. Brann.
Metrics
- h-index: 31
- Publications: 78
- Citations: 21,806
Selected Publications
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Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during <i>L. major</i> infection and promote host defense to infection (2026)
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Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives (2026)
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<i>Coxiella burnetii</i> Nine Mile II Δ <i>cbu0533</i> as a suitable laboratory replacement strain (2025)
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β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025)
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Control of human Q fever by vaccination: the journey to Q-VAX and beyond (2025)
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Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages (2025)
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The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology (2025)
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<i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages (2025)
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Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells (2025)
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Embracing multiple infection models to tackle Q fever: A review of in vitro, in vivo, and lung ex vivo models (2024)
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Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii (2024)
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MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i> (2022)
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Editorial: Obligate intracellular bacteria: Evasion and adaptative tactics shaping the host-pathogen interface (2022)
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Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection (2022)
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MicroRNAs contribute to the host response to <i>Coxiella burnetii</i> (2022)
Federal Grants 4 $8,412,384 total
Defining the impact of host-directed drugs on Coxiella burnetii growth in macrophages
Coxiella burnetii Subversion of Host Nrf2 Antioxidant Signaling- Resubmission
Glycan Expression Analysis using an Odyssey CLx Infrared Imaging System
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Coxiella burnetii Regulation of Macrophage cAMP/PKA Signaling NIH Principal Investigator
- Bacterial cell wall synthesis, shape and septation NIH Principal Investigator
- Role of the Coxiella burnetii Cryptic Plasmid in Host Cell Parasitism NIH Principal Investigator
- Manipulation of host signaling by the Q fever agent, Coxiella burnetii American Heart Association (South Central Affiliate) Principal Investigator
- A Novel Human Lung Infection Platform to Define Staphylococcus aureus Virulence Determinants NIH Principal Investigator
- Defining Coxiella burnetii Infection of Primary Human Cardiac Cells NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Expanding UAMS Research Capacity to Investigate the Host Response to Infectious Disease NIH/Office of the Director Principal Investigator
- Characterization of the Human Lung Response to Coxiella burnetii NIH Principal Investigator
- Functional Characterization of Coxiella burnetii Dot/Icm Substrates NIH Principal Investigator
Collaboration Network
Top Collaborators
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i>
- Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii
- Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives
- MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i>
- MicroRNAs contribute to the host response to <i>Coxiella burnetii</i>
- <i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
- MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i>
- MicroRNAs contribute to the host response to <i>Coxiella burnetii</i>
- <i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
- Take my breath away: studying pathogen invasion of the human lung using primary tissue models
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i>
- MicroRNAs contribute to the host response to <i>Coxiella burnetii</i>
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
- The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology
- β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395
- The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology
- Control of human Q fever by vaccination: the journey to Q-VAX and beyond
- <i>Coxiella burnetii</i> Nine Mile II Δ <i>cbu0533</i> as a suitable laboratory replacement strain
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
- β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395
- Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells
- <i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages
- <i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
- The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
- Control of human Q fever by vaccination: the journey to Q-VAX and beyond
- <i>Coxiella burnetii</i> Nine Mile II Δ <i>cbu0533</i> as a suitable laboratory replacement strain
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
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