Daniel E. Voth
Department Chairperson
Also affiliated: National Institutes of Health (2007–2010); Harvard University (2003); University of Arkansas Medical Center (2016); National Institute of Allergy and Infectious Diseases (2007–2010); University of Oklahoma Health Sciences Center (2005–2007); University of Oklahoma (2003–2004); Stanford University (2006)
Department Chairs, College of Medicine
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Daniel E. Voth's research program focuses on understanding the molecular mechanisms by which intracellular bacterial pathogens, particularly *Coxiella burnetii*, interact with and subvert host cell processes. His work has investigated the role of bacterial secretion systems, such as the Dot/Icm Type IVB secretion system, in facilitating pathogen growth and survival within host macrophages. Voth has also explored the genomic plasticity of *Coxiella* and the diversity of its effector proteins. His research extends to understanding host cell pathways, including autophagy and the Nrf2 antioxidant signaling pathway, and how these are manipulated by bacterial pathogens.
Voth has received significant federal funding for his work, including multiple grants from the National Institutes of Health (NIH). Notably, he served as PI on a large NIH grant totaling $7,975,000 to establish a Center for Animal Models of Infection and Disease (CAMID). Other NIH grants he has led include funding for studies on *Coxiella burnetii*'s subversion of host signaling and glycan expression analysis. His scholarship metrics include an h-index of 31, with 76 publications and over 21,000 citations, identifying him as a highly cited researcher.
His collaborations include work with Amanda L. Dragan, Het Adhvaryu, Marissa S. Fullerton, and Katelynn R. Brann, all affiliated with the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications. Voth currently serves as Department Chairperson in the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 31
- Publications: 71
- Citations: 21,778
Positions
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Vice Chancellor for Research and Innovation 2024–presentUniversity of Arkansas for Medical Sciences Microbiology and Immunology ORCID
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Department Chairperson publications 2010–2026University of Arkansas for Medical Sciences Department Chairs, College of Medicine Institutional directory
Selected Publications
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Breathing and burning: metabolic control of alveolar macrophages by intracellular bacterial pathogens (2026)
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Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during L. major infection and promote host defense to infection (2026)
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Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives (2026)
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Coxiella burnetii Nine Mile II Δ cbu0533 as a suitable laboratory replacement strain (2025)
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β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025)
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Control of human Q fever by vaccination: the journey to Q-VAX and beyond (2025)
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Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages (2025)
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The intracellular agent of Q fever, Coxiella burnetii , alters human alveolar macrophage metabolism and mitochondrial physiology (2025)
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Coxiella burnetii strains elicit distinct inflammatory responses in human macrophages (2025)
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Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells (2025)
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Embracing multiple infection models to tackle Q fever: A review of in vitro, in vivo, and lung ex vivo models (2024)
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Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii (2024)
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MicroRNAs Contribute to Host Response to Coxiella burnetii (2022)
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Editorial: Obligate intracellular bacteria: Evasion and adaptative tactics shaping the host-pathogen interface (2022)
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Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection (2022)
Federal Grants 4 $8,412,384 total
Defining the impact of host-directed drugs on Coxiella burnetii growth in macrophages
Coxiella burnetii Subversion of Host Nrf2 Antioxidant Signaling- Resubmission
Glycan Expression Analysis using an Odyssey CLx Infrared Imaging System
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Coxiella burnetii Regulation of Macrophage cAMP/PKA Signaling NIH Principal Investigator
- Bacterial cell wall synthesis, shape and septation NIH Principal Investigator
- Role of the Coxiella burnetii Cryptic Plasmid in Host Cell Parasitism NIH Principal Investigator
- Manipulation of host signaling by the Q fever agent, Coxiella burnetii American Heart Association (South Central Affiliate) Principal Investigator
- A Novel Human Lung Infection Platform to Define Staphylococcus aureus Virulence Determinants NIH Principal Investigator
- Defining Coxiella burnetii Infection of Primary Human Cardiac Cells NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Expanding UAMS Research Capacity to Investigate the Host Response to Infectious Disease NIH/Office of the Director Principal Investigator
- Characterization of the Human Lung Response to Coxiella burnetii NIH Principal Investigator
- Functional Characterization of Coxiella burnetii Dot/Icm Substrates NIH Principal Investigator
Collaboration Network
Top Collaborators
- Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
- Coxiella burnetii Type IV Secretion-Dependent Recruitment of Macrophage Autophagosomes
- Development of an Ex Vivo Tissue Platform To Study the Human Lung Response to Coxiella burnetii
- Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages
- Coxiella burnetiiexploits host cAMP-dependent protein kinase signalling to promote macrophage survival
Showing 5 of 11 shared publications
- Bacterial Type IV Secretion Systems: Versatile Virulence Machines
- Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
- Coxiella burnetii Type IV Secretion-Dependent Recruitment of Macrophage Autophagosomes
- Development of an Ex Vivo Tissue Platform To Study the Human Lung Response to Coxiella burnetii
- Coxiella burnetiiexploits host cAMP-dependent protein kinase signalling to promote macrophage survival
Showing 5 of 9 shared publications
- Hijacking Host Cell Highways: Manipulation of the Host Actin Cytoskeleton by Obligate Intracellular Bacterial Pathogens
- Coxiella burnetii Type IV Secretion-Dependent Recruitment of Macrophage Autophagosomes
- Dining in: intracellular bacterial pathogen interplay with autophagy
- Development of an Ex Vivo Tissue Platform To Study the Human Lung Response to Coxiella burnetii
- Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages
Showing 5 of 8 shared publications
- Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens
- Infection of Primary Human Alveolar Macrophages Alters Staphylococcus aureus Toxin Production and Activity
- Coxiella burnetii Requires Host Eukaryotic Initiation Factor 2α Activity for Efficient Intracellular Replication
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- MicroRNAs Contribute to Host Response to Coxiella burnetii
Showing 5 of 7 shared publications
- Dot/Icm Type IVB Secretion System Requirements for Coxiella burnetii Growth in Human Macrophages
- TheCoxiella burnetiiCryptic Plasmid Is Enriched in Genes Encoding Type IV Secretion System Substrates
- Coxiella burnetii Effector Proteins That Localize to the Parasitophorous Vacuole Membrane Promote Intracellular Replication
- Identification of Anaplasma marginale Type IV Secretion System Effector Proteins
- Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages
Showing 5 of 6 shared publications
- Coxiella burnetii: international pathogen of mystery
- Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages
- Characterization of Early Stages of Human Alveolar Infection by the Q Fever Agent Coxiella burnetii
- Take my breath away: studying pathogen invasion of the human lung using primary tissue models
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
Showing 5 of 6 shared publications
- Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages
- Infection of Primary Human Alveolar Macrophages Alters Staphylococcus aureus Toxin Production and Activity
- Coxiella burnetii Requires Host Eukaryotic Initiation Factor 2α Activity for Efficient Intracellular Replication
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- MicroRNAs Contribute to Host Response to Coxiella burnetii
Showing 5 of 6 shared publications
- The intracellular agent of Q fever, Coxiella burnetii , alters human alveolar macrophage metabolism and mitochondrial physiology
- Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells
- Coxiella burnetii strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
- Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during L. major infection and promote host defense to infection
Showing 5 of 6 shared publications
- Dot/Icm Type IVB Secretion System Requirements for Coxiella burnetii Growth in Human Macrophages
- TheCoxiella burnetiiCryptic Plasmid Is Enriched in Genes Encoding Type IV Secretion System Substrates
- Coxiella burnetii Effector Proteins That Localize to the Parasitophorous Vacuole Membrane Promote Intracellular Replication
- Identification of Anaplasma marginale Type IV Secretion System Effector Proteins
- Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages
- Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
- Coxiella burnetiiexploits host cAMP-dependent protein kinase signalling to promote macrophage survival
- Coxiella burnetii Alters Cyclic AMP-Dependent Protein Kinase Signaling during Growth in Macrophages
- Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages
- TheCoxiella burnetiiCryptic Plasmid Is Enriched in Genes Encoding Type IV Secretion System Substrates
- Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
- Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation
- Identification of ElpA, a Coxiella burnetii Pathotype-Specific Dot/Icm Type IV Secretion System Substrate
- Hijacking Host Cell Highways: Manipulation of the Host Actin Cytoskeleton by Obligate Intracellular Bacterial Pathogens
- Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens
- Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- MicroRNAs Contribute to Host Response to Coxiella burnetii
- MicroRNAs contribute to the host response to Coxiella burnetii
- Coxiella burnetii strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
- MicroRNAs Contribute to Host Response to Coxiella burnetii
- MicroRNAs contribute to the host response to Coxiella burnetii
- Coxiella burnetii strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
- Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
- Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation
- Coxiella Subversion of Intracellular Host Signaling
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