Daniel E. Voth
Federal Grant PI
High Impact
Department Chairperson
faculty
Department Chairs, College of Medicine
30 h-index
77 pubs
21,647 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Daniel E. Voth's research program focuses on understanding host-pathogen interactions, particularly concerning intracellular bacterial pathogens like *Coxiella burnetii*, the causative agent of Q fever. His work investigates the mechanisms by which these bacteria subvert host cellular processes, such as antioxidant signaling pathways, to establish infection. Voth also explores strategies for combating these infections, including the evaluation of host-directed drugs that can target bacterial growth within human cells. His laboratory employs a range of infection models, including in vitro cell cultures, in vivo animal models, and ex vivo lung tissue models, to gain comprehensive insights into pathogen invasion and host defense.
Metrics
- h-index: 30
- Publications: 77
- Citations: 21,647
Selected Publications
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Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives (2026)
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<i>Coxiella burnetii</i> Nine Mile II Δ <i>cbu0533</i> as a suitable laboratory replacement strain (2025)
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β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025)
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Control of human Q fever by vaccination: the journey to Q-VAX and beyond (2025)
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Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages (2025)
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The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology (2025)
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<i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages (2025)
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Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells (2025)
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Embracing multiple infection models to tackle Q fever: A review of in vitro, in vivo, and lung ex vivo models (2024)
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Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii (2024)
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MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i> (2022)
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Editorial: Obligate intracellular bacteria: Evasion and adaptative tactics shaping the host-pathogen interface (2022)
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Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection (2022)
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MicroRNAs contribute to the host response to <i>Coxiella burnetii</i> (2022)
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Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells (2021)
Federal Grants 4 $8,412,384 total
NIH/National Institute of Allergy and Infectious Diseases
Contact PI
Jun 2024 - Apr 2027
Defining the impact of host-directed drugs on Coxiella burnetii growth in macrophages
NIH/NIH Office of the Director
Contact PI
Sep 2022 - May 2027
NIH/National Institute of Allergy and Infectious Diseases
Contact PI
Sep 2020 - Aug 2023
Coxiella burnetii Subversion of Host Nrf2 Antioxidant Signaling- Resubmission
NIH/National Institute of General Medical Sciences
Contact PI
Mar 2000 - Dec 2022
Glycan Expression Analysis using an Odyssey CLx Infrared Imaging System
Grants & Funding
- Coxiella burnetii Regulation of Macrophage cAMP/PKA Signaling NIH Principal Investigator
- Defining the impact of host-directed drugs on Coxiella burnetii growth in macrophages UAMS Internal Research Awards Principal Investigator
- Bacterial cell wall synthesis, shape and septation NIH Principal Investigator
- Role of the Coxiella burnetii Cryptic Plasmid in Host Cell Parasitism NIH Principal Investigator
- Manipulation of host signaling by the Q fever agent, Coxiella burnetii American Heart Association (South Central Affiliate) Principal Investigator
- Coxiella burnetii Subversion of Host Nrf2 Antioxidant Signaling- Resubmission NIH Principal Investigator
- A Novel Human Lung Infection Platform to Define Staphylococcus aureus Virulence Determinants NIH Principal Investigator
- Defining Coxiella burnetii Infection of Primary Human Cardiac Cells NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
Collaboration Network
Top Collaborators
Madhur Sachan
Brigham and Women's Hospital (US)
4 shared publications
- MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i>
- MicroRNAs contribute to the host response to <i>Coxiella burnetii</i>
- <i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
Rahul Raghavan
The University of Texas at San Antonio (US)
4 shared publications
- MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i>
- MicroRNAs contribute to the host response to <i>Coxiella burnetii</i>
- <i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
Marissa S. Fullerton
University of Arkansas for Medical Sciences
3 shared publications
In database
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i>
- Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii
Katelynn R. Brann
University of Arkansas for Medical Sciences
3 shared publications
In database
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
- MicroRNAs Contribute to Host Response to <i>Coxiella burnetii</i>
- MicroRNAs contribute to the host response to <i>Coxiella burnetii</i>
Lu Huang
University of Arkansas for Medical Sciences
3 shared publications
In database
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
- The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology
- β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395
Carrie M. Long
National Institute of Allergy and Infectious Diseases (US)
3 shared publications
- The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology
- Control of human Q fever by vaccination: the journey to Q-VAX and beyond
- <i>Coxiella burnetii</i> Nine Mile II Δ <i>cbu0533</i> as a suitable laboratory replacement strain
Amanda L. Dragan
University of Arkansas for Medical Sciences
2 shared publications
In database
- Take my breath away: studying pathogen invasion of the human lung using primary tissue models
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
J. Tucker Andrews
University of Arkansas for Medical Sciences
2 shared publications
In database
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
- β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395
Het Adhvaryu
University of Arkansas for Medical Sciences (US)
2 shared publications
- Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells
- <i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages
Anette Dragan
University of Arkansas for Medical Sciences (US)
2 shared publications
- <i>Coxiella burnetii</i> strains elicit distinct inflammatory responses in human macrophages
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
Het Adhvaryu
University of Arkansas for Medical Sciences
2 shared publications
In database
- The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology
- Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages
K. Pierce
University of Arkansas for Medical Sciences (US)
2 shared publications
- Control of human Q fever by vaccination: the journey to Q-VAX and beyond
- <i>Coxiella burnetii</i> Nine Mile II Δ <i>cbu0533</i> as a suitable laboratory replacement strain
Punsiri M. Colonne
University of Arkansas for Medical Sciences
1 shared publication
In database
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
Richard C. Kurten
University of Arkansas for Medical Sciences
1 shared publication
In database
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells
Stanley Ching‐Cheng Huang
Case Western Reserve University (US)
1 shared publication
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
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