Fabricio Medina-Bolívar Institution Verified

Sourced from institutional research profiles (UAMS TRI or ARA).

◆ ARA Academy High Impact

Professor

Arkansas State University

faculty

23 h-index 59 pubs 1,859 cited

Research Areas

Links

ORCID Lab Website

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OverviewAI-generated summary

Fabricio Medina-Bolívar's research focuses on the production and characterization of bioactive compounds from plant sources, particularly prenylated stilbenoids and flavonoids. His work investigates methods for enhancing the production of these compounds in hairy root cultures, employing elicitation techniques to stimulate plant defense responses and increase yields. These compounds are studied for their potential therapeutic applications, including anticancer and anti-inflammatory properties.

Medina-Bolívar's recent publications detail the induction and purification of specific compounds like arachidin-1, arachidin-3, and isowighteone from various plant species, including peanut (Arachis hypogaea L.), white mulberry (Morus alba), and pigeon pea (Cajanus cajan). His research also explores the antioxidant potential of plant extracts and the enhancement of anticancer effects of known chemotherapeutic agents by plant-derived compounds. He has published 59 works with 1,859 citations and an h-index of 23. His collaborations include Gaurav Gajurel, Amit Raj Sharma, Robert C. Shields, and Rokib Hasan, all from Arkansas State University.

Metrics

h-index: 23
Publications: 59
Citations: 1,859

Selected Publications

Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection (2026) DOI
Prenylated Stilbenoids Confer Sex-Dependent Cardioprotection in Rats (2025) DOI
Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (<i>Cajanus cajan</i>) Hairy Root Cultures (2025) DOI
Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea (2025) DOI
Stilbene-rich extract increases the cytotoxic effects of paclitaxel in hormone receptor-positive and triple-negative breast cancer spheroids (2024) DOI
Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation (2024) DOI
Water Deficit Stress Induces Prenylated Stilbenoid Production and Reduces Root Biomass in Peanut: Role of Stilbenoid Prenyltransferase Downregulation (2024) DOI
Effect of peanut stilbenoids, arachidin-1 and arachidin-3, on <i>Streptococcus mutans</i> growth and acid production (2024) DOI
Arachidin-1, a Prenylated Stilbenoid from Peanut, Enhances the Anticancer Effects of Paclitaxel in Triple-Negative Breast Cancer Cells (2023) DOI
Elicitation of Stilbenes and Benzofuran Derivatives in Hairy Root Cultures of White Mulberry (Morus alba) (2022) DOI
Correction: Gajurel et al. Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors. Plants 2022, 11, 834 (2022) DOI
Induction of the Prenylated Stilbenoids Arachidin-1 and Arachidin-3 and Their Semi-Preparative Separation and Purification from Hairy Root Cultures of Peanut (Arachis hypogaea L.) (2022) DOI
Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors (2022) DOI
Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells (2022) DOI
Antioxidant Assessment of Prenylated Stilbenoid-Rich Extracts from Elicited Hairy Root Cultures of Three Cultivars of Peanut (Arachis hypogaea) (2021) DOI

ARA Academy 2021 ARA Fellow

Dr. Medina-Bolivar has served as faculty at A-State since 2005, directing research at the Arkansas Biosciences Institute. With over 25 years of experience in plant biotechnology, he is recognized globally for pioneering hairy root culture systems to develop natural products. He is a founding member of the American Council for Medicinally Active Plants and was inducted into Arkansas's inaugural Latino Hall of Fame in 2024.

Policy Impact

Over 25 years pioneering plant-based natural product development, strengthening Arkansas State University's biotech research and creating pathways for pharmaceutical commercialization.