Fabricio Medina-Bolívar

Sourced from institutional research profiles (UAMS TRI or ARA).

◆ ARA Academy High Impact

Professor

Arkansas State University

Also affiliated: Pennsylvania State University (1995); Biotechnology Institute (1995); Indiana University Bloomington (2016); Arkansas Biosciences Institute (2007–2025); Virginia Tech (2003–2005)

Faculty Researcher

24 h-index 59 pubs 1,914 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website

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OverviewAI-generated summary

Fabricio Medina-Bolívar's research focuses on the production and application of plant-derived compounds, particularly prenylated stilbenoids from peanut (Arachis hypogaea L.). His work investigates the induction and purification of these compounds, such as arachidin-1 and arachidin-3, from hairy root cultures.

Medina-Bolívar's studies have explored the potential of these prenylated stilbenoids in therapeutic applications. Recent publications demonstrate that arachidin-1 can induce apoptosis in triple-negative breast cancer cells and enhance the efficacy of paclitaxel in treating these cancer cells. His research also extends to other plant-derived compounds, including benzofuran derivatives and geranylated flavonoids with antimicrobial and anti-inflammatory activities.

His laboratory employs plant biotechnology techniques, including the use of genetically modified plants and hairy root cultures, to facilitate the production of these bioactive molecules. Medina-Bolívar is a recipient of National Science Foundation grants for the acquisition of advanced analytical instrumentation, including UHPLC-TQ and NMR, which support interdisciplinary research in ecotoxicology and analytical chemistry. He has published 59 papers with 1,898 citations and an h-index of 23. Key collaborators include Gaurav Gajurel, Amit Raj Sharma, Robert C. Shields, and Rokib Hasan, all from Arkansas State University.

Metrics

h-index: 24
Publications: 59
Citations: 1,914

Selected Publications

Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection (2026)

ChemRxiv 1 citation DOI OpenAlex
High-level production of antibacterial pentacyclic triterpenoids from hairy root cultures of Bixa orellana via abiotic elicitation (2026)

Industrial Crops and Products DOI OpenAlex
Prenylated Stilbenoids Confer Sex-Dependent Cardioprotection in Rats (2025)

Physiology DOI OpenAlex
Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (<i>Cajanus cajan</i>) Hairy Root Cultures (2025)

Journal of Agricultural and Food Chemistry 5 citations DOI OpenAlex
Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea (2025)

Plants 3 citations DOI OpenAlex
Stilbene-rich extract increases the cytotoxic effects of paclitaxel in hormone receptor-positive and triple-negative breast cancer spheroids (2024)

Phytomedicine Plus DOI OpenAlex
Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation (2024)

Plant Physiology and Biochemistry 3 citations DOI OpenAlex
Water Deficit Stress Induces Prenylated Stilbenoid Production and Reduces Root Biomass in Peanut: Role of Stilbenoid Prenyltransferase Downregulation (2024)

SSRN Electronic Journal DOI OpenAlex
Effect of peanut stilbenoids, arachidin-1 and arachidin-3, on <i>Streptococcus mutans</i> growth and acid production (2024)

Natural Product Research 3 citations DOI OpenAlex
Arachidin-1, a Prenylated Stilbenoid from Peanut, Enhances the Anticancer Effects of Paclitaxel in Triple-Negative Breast Cancer Cells (2023)

Cancers 12 citations DOI OpenAlex
Elicitation of Stilbenes and Benzofuran Derivatives in Hairy Root Cultures of White Mulberry (Morus alba) (2022)

Plants 20 citations DOI OpenAlex
Correction: Gajurel et al. Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors. Plants 2022, 11, 834 (2022)

Plants DOI OpenAlex
Induction of the Prenylated Stilbenoids Arachidin-1 and Arachidin-3 and Their Semi-Preparative Separation and Purification from Hairy Root Cultures of Peanut (Arachis hypogaea L.) (2022)

Molecules 17 citations DOI OpenAlex
Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors (2022)

Plants 16 citations DOI OpenAlex
Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells (2022)

International Journal of Molecular Sciences 23 citations DOI OpenAlex

View all publications on OpenAlex →

ARA Academy 2021 ARA Fellow

Dr. Medina-Bolivar has served as faculty at A-State since 2005, directing research at the Arkansas Biosciences Institute. With over 25 years of experience in plant biotechnology, he is recognized globally for pioneering hairy root culture systems to develop natural products. He is a founding member of the American Council for Medicinally Active Plants and was inducted into Arkansas's inaugural Latino Hall of Fame in 2024.

Policy Impact

Over 25 years pioneering plant-based natural product development, strengthening Arkansas State University's biotech research and creating pathways for pharmaceutical commercialization.