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OverviewAI-generated summary
Pankaj Patyal's research investigates the molecular mechanisms underlying neuroinflammatory diseases, with a particular focus on the role of mitochondrial dysfunction and oxidative stress. His work examines the impact of bacterial components, such as lipopolysaccharides from *Porphyromonas gingivalis*, on cellular processes relevant to neurological conditions. Patyal has studied how these factors contribute to neuroinflammation and neurodegeneration, exploring pathways involving serum response factor (SRF) and inflammasome activation. His publications also touch upon the influence of dietary components, like valine, on mitochondrial health and oxidative stress resistance. Collaborating with researchers at the University of Arkansas for Medical Sciences, Patyal has contributed to a body of work exploring these complex biological interactions. His research output includes 34 publications with 249 citations and an h-index of 8.
Metrics
- h-index: 8
- Publications: 35
- Citations: 268
Selected Publications
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Biology of Aging I Antisense Oligonucleotide-Mediated SRF Reduction Ameliorates Mitochondrial Dysfunction in Cardiac Aging (2025)
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P. gingivalis-LPS Activates the Alzheimer’s Disease-Associated Amyloid Secretase Pathway via Caspase-4 (2025)
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Mitochondrial Dynamics in Aging Heart (2025)
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Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025)
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Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025)
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Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function (2025)
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CARDIAC SPECIFIC OVEREXPRESSION OF SERUM RESPONSE FACTOR ALTERS MITOCHONDRIAL STRUCTURE AND FUNCTION (2024)
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DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024)
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DIFFERENTIAL MICRORNAS PROFILING OF MARSHALLESE IN ARKANSAS IS ASSOCIATED WITH CHRONIC DISEASES OF AGING (2024)
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P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024)
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The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function (2024)
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Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells (2024)
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Deletion of Interleukin-1β Converting Enzyme Alters Mouse Cardiac Structure and Function (2024)
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Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome (2024)
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Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function (2024)
Collaboration Network
Top Collaborators
Jeanne Y. Wei
University of Arkansas for Medical Sciences
24 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 24 shared publications
Ambika Verma
University of Arkansas for Medical Sciences
23 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 23 shared publications
Gohar Azhar
Institute on Aging
22 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 22 shared publications
Xiaomin Zhang
Institute on Aging (US)
17 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 17 shared publications
Shakshi Sharma
University of Arkansas for Medical Sciences
9 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES
Showing 5 of 9 shared publications
Robert R. Wolfe
University of Arkansas for Medical Sciences
4 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- EAAS AND WHEY PROTEIN MAY IMPROVE PHYSICAL FUNCTION OF OLDER ADULTS INDEPENDENTLY OF GUT MICROBIOME
Fathima S. Ameer
Institute on Aging (US)
3 shared publications
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- SIRTUIN 1 ISOFORMS DIFFERENTIALLY IMPACT MITOCHONDRIAL GENE EXPRESSION AND FUNCTION IN MUSCLE CELLS
Grishma KC
Institute on Aging (US)
3 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
Yingni Che
University of Arkansas for Medical Sciences
3 shared publications
In database
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- SIRTUIN 1 ISOFORMS DIFFERENTIALLY IMPACT MITOCHONDRIAL GENE EXPRESSION AND FUNCTION IN MUSCLE CELLS
Amanda Pangle
Institute on Aging
3 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Wei Zhang
University of Arkansas at Little Rock
3 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
Yingni Che
University of Arkansas for Medical Sciences (US)
3 shared publications
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Jyotsna Shrivastava
University of Arkansas for Medical Sciences
3 shared publications
In database
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES
- Mitochondrial Dynamics in Aging Heart
Daniel Fil
University of Arkansas for Medical Sciences
2 shared publications
In database
- Plp1 in the enteric nervous system is preferentially expressed during early postnatal development in mouse as DM20, whose expression appears reliant on an intronic enhancer
- PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development
P.A.L. Wight
University of Arkansas for Medical Sciences
2 shared publications
In database
- Plp1 in the enteric nervous system is preferentially expressed during early postnatal development in mouse as DM20, whose expression appears reliant on an intronic enhancer
- PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development
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