Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
J
Jerry Ware
High Impact
Professor
Physiology & Cell Biology, College of Medicine
60 h-index
220 pubs
13,312 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Jerry Ware's research focuses on the role of platelets in various physiological and pathological processes, including thrombosis, inflammation, and cancer. He investigates how these blood components interact with other cells, such as monocytes and neutrophils, to initiate and propagate disease states, particularly venous thrombosis in mouse models.
His work has explored the contribution of platelets to inflammatory conditions like arthritis, where they amplify inflammation through collagen-dependent microparticle production. Furthermore, Ware's research extends to the interface of platelets, inflammation, and cancer, examining their involvement in tumor progression and metastasis. A specific area of investigation includes the function of platelet GPIbα as a mediator and potential therapeutic target in non-alcoholic steatohepatitis (NASH) and subsequent liver cancer. He also studies the role of platelets in supporting angiogenesis while preventing excessive hemorrhage.
Ware has a significant publication record, with over 220 publications and a citation count exceeding 13,000, reflected in his h-index of 60. He has been a Co-PI on two NIH grants totaling over $4.6 million, supporting research in biomedical partnerships and the role of platelets in radiation-induced immune dysregulation. His collaborations include several researchers at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 60
- Publications: 220
- Citations: 13,312
Positions
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Professor 2004–presentUniversity of Arkansas for Medical Sciences Physiology & Cell Biology, College of Medicine Institutional directory
Selected Publications
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Platelet glycoprotein <scp>VI</scp> modulates leukocyte characteristics in sepsis‐induced systemic inflammatory response in male mice (2026)
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Identification and Characterization of Platelet Surface-membrane-derived Microparticles before and after Total-body Irradiation (2025)
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Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis (2025)
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OC 10.3 Platelets Mediate Intracranial Aneurysm Formation and Rupture in Mice (2023)
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Platelet Count and Platelet Volume in Patients with CKD (2023)
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438 Platelets, Inflammation and Thrombosis in Chronic Kidney Disease (2023)
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Ticagrelor inhibits platelet aggregation and reduces inflammatory burden more than clopidogrel in patients with stages 4 or 5 chronic kidney disease (2023)
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Platelet-Dependent Inflammatory Dysregulation in Patients with Stages 4 or 5 Chronic Kidney Disease: A Mechanistic Clinical Study (2022)
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Murine models of glycoprotein Ib-IX (2022)
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Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer (2022)
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Platelet glycoprotein Ibα provides radiation protection (2021)
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Role of Platelets in Chronic Kidney Disease (2021)
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Calcium Ion Chelation Preserves Platelet Function During Cold Storage (2020)
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Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation (2020)
Federal Grants 2 $4,674,158 total
NIH
Co-PI
Jul 2022 - May 2027
NIH
Co-PI
Sep 2001 - Apr 2031
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Leukocyte-platelet modulation of the systemic inflammatory response NIH Principal Investigator
- Transgenic analysis of platelet receptor expression NIH Principal Investigator
- Murine Hemostatic Properties of Thrombosomes DHHS - Biomedical Advanced Research and Development Authority via Cellphire, Inc. Principal Investigator
- In vivo, noninvasive, ultrasensitive photoacoustic detection of early breast cancer metastasis in bone US Department of the Army Principal Investigator
- Characterization and Analysis of Platelet Septins NIH Principal Investigator
- Platelet-leukocyte regulation of inflammatory responses- Resubmission- Resubmission American Heart Association Co-Investigator
- Platelet glycoprotein Ib-IX and malignancy US Department of the Army Principal Investigator
- Resubmission: Structure/Function Determinants of Puncture Wound Thrombus Formation NIH Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Developmental Research Project Program NIH/NIGMS Other
- Platelet glycoprotein VI dependent microparticle formation NIH Principal Investigator
Collaboration Network
Top Collaborators
Susan Russell
University of Arkansas for Medical Sciences (US)
14 shared publications
- Platelet glycoprotein Ibα supports experimental lung metastasis
- Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models
- Platelet Dysfunction and a High Bone Mass Phenotype in a Murine Model of Platelet-Type von Willebrand Disease
- Platelet Glycoprotein Ib-IX as a Regulator of Systemic Inflammation
- Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site
Showing 5 of 14 shared publications
Adam Corken
Arkansas Children's Hospital
12 shared publications
In database
- Platelets at the interface of thrombosis, inflammation, and cancer
- Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation
- Platelet function beyond hemostasis and thrombosis
- Platelet Glycoprotein Ib-IX as a Regulator of Systemic Inflammation
- Role for Platelet Glycoprotein Ib-IX and Effects of its Inhibition in Endotoxemia-Induced Thrombosis, Thrombocytopenia, and Mortality
Showing 5 of 12 shared publications
T. Kent Gartner
University of Memphis (US)
9 shared publications
- Platelet glycoprotein Ibα supports experimental lung metastasis
- Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation
- Platelets, glycoprotein Ib-IX, and von Willebrand factor are required for FeCl3-induced occlusive thrombus formation in the inferior vena cava of mice
- Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling
- FcRγ‐chain signals in the absence of glycoprotein VI
Showing 5 of 9 shared publications
Judith Dent
University of Arkansas for Medical Sciences (US)
9 shared publications
- Platelet glycoprotein Ibα supports experimental lung metastasis
- Platelet Glycoprotein Ib-IX as a Regulator of Systemic Inflammation
- Platelet septin complexes form rings and associate with the microtubular network
- A comparison of washed and volume‐reduced platelets with respect to platelet activation, aggregation, and plasma protein removal
- Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis
Showing 5 of 9 shared publications
Zaverio M. Ruggeri
Scripps Research Institute (US)
9 shared publications
- The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
- The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies
- Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis
- GPIbα is required for platelet-mediated hepatic thrombopoietin generation
- A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
Showing 5 of 9 shared publications
Taisuke Kanaji
Saga Medical School Hospital (JP)
8 shared publications
- Platelet Dysfunction and a High Bone Mass Phenotype in a Murine Model of Platelet-Type von Willebrand Disease
- Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells
- GPIbα regulates platelet size by controlling the subcellular localization of filamin
- Elevated Threshold Shear Rate for the Dependence of Glycoprotein Ibα-Mediated Platelet Thrombus Formation onto Immobilized von Willebrand Factor in Mouse Blood.
- Hyperfunctional Platelets in a Murine Model of Platelet-Type von Willebrand Disease.
Showing 5 of 8 shared publications
Renhao Li
Emory University (US)
7 shared publications
- Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
- Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets
- Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage
- Refrigeration-Induced Binding of von Willebrand Factor Facilitates Fast Clearance of Refrigerated Platelets
- Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site
Showing 5 of 7 shared publications
Bernhard Nieswandt
University of Würzburg (DE)
6 shared publications
- Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation
- The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent
- Blocking Von Willebrand Factor for Treatment of Cutaneous Inflammation
- A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
- Critical Role of Platelet Glycoprotein Ibα in Arterial Remodeling
Showing 5 of 6 shared publications
Nishank Jain
University of Arkansas for Medical Sciences
6 shared publications
In database
- Role of Platelets in Chronic Kidney Disease
- Association of platelet function with depression and its treatment with sertraline in patients with chronic kidney disease: analysis of a randomized trial
- Platelet-Dependent Inflammatory Dysregulation in Patients with Stages 4 or 5 Chronic Kidney Disease: A Mechanistic Clinical Study
- Ticagrelor inhibits platelet aggregation and reduces inflammatory burden more than clopidogrel in patients with stages 4 or 5 chronic kidney disease
- Platelet Count and Platelet Volume in Patients with CKD
Showing 5 of 6 shared publications
Mark L. Kahn
MARK Resources (United States) (US)
5 shared publications
- Platelet ITAM signaling is critical for vascular integrity in inflammation
- Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role
- Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site
- Specific Inhibition Of Ectodomain Shedding Of GPIba By Targeting Its Shedding Cleavage Site
- Abstract 486: Platelet ITAM Signaling is Critical for Maintenance of Vascular Integrity in Inflammation
Steven R. Post
University of Arkansas for Medical Sciences
5 shared publications
In database
- Platelet Glycoprotein Ib-IX as a Regulator of Systemic Inflammation
- Prostaglandins produced during class A scavenger receptor-mediated macrophage adhesion differentially regulate cytokine production
- Platelets: balancing the septic triad
- Platelets and Inflammatory Disorders of Connective Tissue
- The Platelet Glycoprotein Ib-IX Axis In Murine Polymicrobial Sepsis
Xin Liang
Emory University (US)
5 shared publications
- Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
- Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets
- Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage
- Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site
- Specific Inhibition Of Ectodomain Shedding Of GPIba By Targeting Its Shedding Cleavage Site
Denisa D. Wagner
Boston Children's Hospital (US)
5 shared publications
- The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
- The Role of Platelet Adhesion Receptor GPIb α Far Exceeds That of Its Main Ligand von Willebrand Factor in Arterial Thrombosis.
- A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis
- Elevated Threshold Shear Rate for the Dependence of Glycoprotein Ibα-Mediated Platelet Thrombus Formation onto Immobilized von Willebrand Factor in Mouse Blood.
- GPIbα Is Essential for Platelet Adhesion during Thrombus Formation: Studies with Mutant Mice Deficient in the Extracellular Domain of GPIbα.
Constantino Martı́nez
University of Arkansas for Medical Sciences (US)
4 shared publications
- Platelet septin complexes form rings and associate with the microtubular network
- Mammalian Septin Function in Hemostasis and Beyond
- Septins and Platelets
- A Dynamic Regulation of Platelet Secretion by Septin Proteins.
Wolfgang Bergmeier
University of North Carolina at Chapel Hill (US)
4 shared publications
- Platelet ITAM signaling is critical for vascular integrity in inflammation
- The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
- Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
- Abstract 486: Platelet ITAM Signaling is Critical for Maintenance of Vascular Integrity in Inflammation
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