Biography and Research Information
OverviewAI-generated summary
Hayden Roys, a faculty member at the University of Arkansas for Medical Sciences, investigates host-pathogen interactions with a focus on leishmaniasis. Roys's recent work has explored the transcriptional landscape of mice infected with *Leishmania major* using single-cell resolution techniques, revealing cellular heterogeneity and altered transcriptomic profiles within lesions. Further research has examined the role of hypoxia-inducible factor (HIF) signaling in macrophages, demonstrating its impact on macrophage function and inflammatory responses during *Leishmania major* infection. This signaling pathway has also been linked to the promotion of lymphangiogenesis in infected tissues. Roys has also studied the enhanced translational activity in lymphatic endothelial cells during cutaneous leishmaniasis. Collaborations include extensive work with Anne K. Bowlin, Lucy Fry, and Gopinath Venugopal, with whom Roys has co-authored numerous publications.
Metrics
- h-index: 4
- Publications: 20
- Citations: 113
Selected Publications
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Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during <i>L. major</i> infection and promote host defense to infection (2026)
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Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis 4267 (2025)
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Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells (2025)
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Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis (2025)
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Enhanced Translational Activity Is Linked to Lymphatic Endothelial Cell Activation in Cutaneous Leishmaniasis (2025)
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HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection (2025)
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HIF-α signaling regulates the macrophage inflammatory response during <i>Leishmania major</i> infection (2024)
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Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs (2024)
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Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis (2024)
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Distinct lymphatic remodeling is associated with healing and non-healing murine cutaneous leishmaniasis (2023)
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In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution (2022)
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Erratum for Weinkopff et al., “ <i>Leishmania</i> Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner” (2022)
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HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection (2021)
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HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection (2021)
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In vivo reprogramming of murine host immune response genes following Leishmania major infection (2021)
Collaboration Network
Top Collaborators
Anne K. Bowlin
University of Arkansas for Medical Sciences
19 shared publications
In database
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
Showing 5 of 19 shared publications
Tiffany Weinkopff
University of Arkansas for Medical Sciences
18 shared publications
In database
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
Showing 5 of 18 shared publications
Lucy Fry
University of Arkansas for Medical Sciences
15 shared publications
In database
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 15 shared publications
Gopinath Venugopal
University of Arkansas for Medical Sciences (US)
11 shared publications
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
Showing 5 of 11 shared publications
Jordan T. Bird
University of Arkansas for Medical Sciences (US)
11 shared publications
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 11 shared publications
Charity L. Washam
University of Arkansas for Medical Sciences
9 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 9 shared publications
Stephanie D. Byrum
Arkansas Children's Hospital
9 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
Showing 5 of 9 shared publications
Alexx Weaver
University of Arkansas for Medical Sciences
4 shared publications
In database
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
- Enhanced Translational Activity Is Linked to Lymphatic Endothelial Cell Activation in Cutaneous Leishmaniasis
- Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis 4267
Humphrey Wanjala
University of Arkansas for Medical Sciences
3 shared publications
In database
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
Manjunath Bettadapura
University of Arkansas for Medical Sciences
3 shared publications
In database
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
Stephanie D. Byrum
3 shared publications
- Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis 4267
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection 4332
Steven Murdock
University of Arkansas for Medical Sciences
2 shared publications
In database
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
Flavia Neto de Jesus
2 shared publications
- Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis
- Impaired lymphatic remodeling leads to immunopathology during non-healing cutaneous leishmaniasis 4376
Matheus Batista Heitor Carneiro
2 shared publications
- Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis
- Impaired lymphatic remodeling leads to immunopathology during non-healing cutaneous leishmaniasis 4376
Nathan C. Peters
2 shared publications
- Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis
- Impaired lymphatic remodeling leads to immunopathology during non-healing cutaneous leishmaniasis 4376
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