Karen L. McKim
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Researcher
Also affiliated: United States Food and Drug Administration (1998–2021)
Faculty Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Karen L. McKim's research focuses on the molecular mechanisms underlying cancer development, particularly in the context of carcinogens and genotoxicity. Her work investigates the identification and assessment of driver mutations in various cancer types, including breast and lung neoplasms, using advanced techniques like CarcSeq. McKim has published research correlating these mutations with spontaneous cancer incidence in animal models, examining strain- and sex-related differences. Her scholarship metrics include an h-index of 12 and 332 total citations across 28 publications. Key collaborators include Barbara L. Parsons, Kelly L. Harris, Binsheng Gong, and Meagan B. Myers, all from the National Center for Toxicological Research, with whom she has co-authored multiple publications.
Metrics
- h-index: 12
- Publications: 28
- Citations: 346
Selected Publications
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Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia (2021)
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Quantification of cancer driver mutations in human breast and lung <scp>DNA</scp> using targeted, error‐corrected <scp>CarcSeq</scp> (2020)
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Outgrowth of erlotinib-resistant subpopulations recapitulated in patient-derived lung tumor spheroids and organoids (2020)
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ACB-PCR Quantification of Low-Frequency Hotspot Cancer-Driver Mutations (2020)
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Rationale and Roadmap for Developing Panels of Hotspot Cancer Driver Gene Mutations as Biomarkers of Cancer Risk (2019)
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Low-Frequency Mutational Heterogeneity of Invasive Ductal Carcinoma Subtypes: Information to Direct Precision Oncology (2019)
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Lifespan <i>Kras</i> mutation levels in lung and liver of B6C3F<sub>1</sub> mice (2018)
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Variation in organ‐specific <i>PIK3CA</i> and <i>KRAS</i> mutant levels in normal human tissues correlates with mutation prevalence in corresponding carcinomas (2017)
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Dose and temporal evaluation of ethylene oxide‐induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations (2017)
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Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status (2017)
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Abstract A15: Establishing an ex-vivo, tumor spheroid culture system to assess molecular-targeted therapies for personalized treatment of non-small cell lung cancer (2016)
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Abstract 5147: Characterization of the tissue-specific properties of cancer driver mutations suggests spontaneous mutation in normal tissues drives tumor susceptibility (2016)
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Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas (2016)
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Quantification of Kras mutant fraction in the lung DNA of mice exposed to aerosolized particulate vanadium pentoxide by inhalation (2015)
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Abstract 1119: Subclonal structure of breast cancer subtypes determined by quantitative analyses of activating mutations (2015)
Collaboration Network
Top Collaborators
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
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