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Biography and Research Information
OverviewAI-generated summary
Jiaojiao Fan's research focuses on understanding and mitigating kidney disease progression, particularly the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Fan has investigated the therapeutic potential of hypoxia-inducible factor prolyl hydroxylase inhibitors for nonanemic diseases and explored how specific molecular targets, such as LONP1 and TP53RK, influence mitochondrial function and disease progression in CKD. Additionally, Fan has studied the protective effects of compounds like the 3-phenylglutaric acid derivative (84-B10) against cisplatin-induced AKI by targeting ferroptosis and mitochondrial oxidative stress. The research also extends to therapeutic strategies for podocyte mitochondrial dysfunction in focal segmental glomerulosclerosis and the role of human endogenous retrovirus type K encoded Np9 oncoprotein in inducing DNA damage response. Fan's work has resulted in 58 publications, with an h-index of 12 and 553 citations.
Metrics
- h-index: 12
- Publications: 56
- Citations: 558
Selected Publications
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Roles of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway in Oncovirus Infection and Virus-Associated Cancers (2025)
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Infection of human induced pluripotent stem cells by an oncogenic herpesvirus (2025)
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Identification of RP‐54745, an IL‐1 Inhibitor Displaying Anticancer Activities for KSHV‐Related Primary Effusion Lymphoma (2025)
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Alterations in Cellular Gene Expression Due to Co‐Infection With Kaposi's Sarcoma‐Associated Herpesvirus and SARS‐CoV‐2: Implications for Disease Severity (2024)
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SS-31 Attenuates Doxorubicin-induced Cardiomyoblast H9C2 Cell Senescence (2024)
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Roles of Human Endogenous Retrovirus-K-Encoded Np9 in Human Diseases: A Small Protein with Big Functions (2024)
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Human endogenous retrovirus type K encoded Np9 oncoprotein induces DNA damage response (2024)
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Development of human endogenous retrovirus type K‐ related treatments for human diseases (2024)
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Mitochondrial proton leak in cardiac aging (2023)
Collaboration Network
Top Collaborators
Mengqiu Wu
Nanjing Children's Hospital (CN)
9 shared publications
- <scp>LONP1</scp> targets <scp>HMGCS2</scp> to protect mitochondrial function and attenuate chronic kidney disease
- Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
- Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
- A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis
- Therapeutic Potential Targeting Podocyte Mitochondrial Dysfunction in Focal Segmental Glomerulosclerosis
Showing 5 of 9 shared publications
Mengqiu Miao
Nanjing Children's Hospital (CN)
8 shared publications
- <scp>LONP1</scp> targets <scp>HMGCS2</scp> to protect mitochondrial function and attenuate chronic kidney disease
- Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
- Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
- A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis
- TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5
Showing 5 of 8 shared publications
Aihua Zhang
Second Affiliated Hospital of Nanjing Medical University (CN)
7 shared publications
- <scp>LONP1</scp> targets <scp>HMGCS2</scp> to protect mitochondrial function and attenuate chronic kidney disease
- Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
- Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
- A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis
- Therapeutic Potential Targeting Podocyte Mitochondrial Dysfunction in Focal Segmental Glomerulosclerosis
Showing 5 of 7 shared publications
Zhanjun Jia
Nanjing Children's Hospital (CN)
7 shared publications
- <scp>LONP1</scp> targets <scp>HMGCS2</scp> to protect mitochondrial function and attenuate chronic kidney disease
- Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
- Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
- A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis
- TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5
Showing 5 of 7 shared publications
Yongxin Chen
7 shared publications
- Variational Wasserstein gradient flow
- Improved dimension dependence of a proximal algorithm for sampling
- Nesterov Smoothing for Sampling Without Smoothness
- Nesterov smoothing for sampling without smoothness
- On a Class of Gibbs Sampling over Networks
Showing 5 of 7 shared publications
Yue Zhang
Nanjing Children's Hospital (CN)
6 shared publications
- <scp>LONP1</scp> targets <scp>HMGCS2</scp> to protect mitochondrial function and attenuate chronic kidney disease
- Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
- A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis
- TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5
- Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition
Showing 5 of 6 shared publications
Yuting Li
Nanjing Children's Hospital (CN)
6 shared publications
- <scp>LONP1</scp> targets <scp>HMGCS2</scp> to protect mitochondrial function and attenuate chronic kidney disease
- Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
- Therapeutic Potential Targeting Podocyte Mitochondrial Dysfunction in Focal Segmental Glomerulosclerosis
- Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis
- Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition
Showing 5 of 6 shared publications
Zhiqiang Qin
Winthrop Rockefeller Foundation (US)
6 shared publications
- Human endogenous retrovirus type K encoded Np9 oncoprotein induces DNA damage response
- Roles of Human Endogenous Retrovirus-K-Encoded Np9 in Human Diseases: A Small Protein with Big Functions
- Development of human endogenous retrovirus type K‐ related treatments for human diseases
- Alterations in Cellular Gene Expression Due to Co‐Infection With Kaposi's Sarcoma‐Associated Herpesvirus and SARS‐CoV‐2: Implications for Disease Severity
- Identification of RP‐54745, an IL‐1 Inhibitor Displaying Anticancer Activities for KSHV‐Related Primary Effusion Lymphoma
Showing 5 of 6 shared publications
Yujia Niu
Nanjing Children's Hospital (CN)
5 shared publications
- A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis
- Therapeutic Potential Targeting Podocyte Mitochondrial Dysfunction in Focal Segmental Glomerulosclerosis
- Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis
- Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition
- Corrigendum to “A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis” [Free Radic. Biol. Med. 194 (2023) 84–98]
Lu Dai
Winthrop Rockefeller Foundation
5 shared publications
In database
- Human endogenous retrovirus type K encoded Np9 oncoprotein induces DNA damage response
- Development of human endogenous retrovirus type K‐ related treatments for human diseases
- Identification of RP‐54745, an IL‐1 Inhibitor Displaying Anticancer Activities for KSHV‐Related Primary Effusion Lymphoma
- Infection of human induced pluripotent stem cells by an oncogenic herpesvirus
- Roles of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway in Oncovirus Infection and Virus-Associated Cancers
Mi Bai
Nanjing Children's Hospital (CN)
4 shared publications
- <scp>LONP1</scp> targets <scp>HMGCS2</scp> to protect mitochondrial function and attenuate chronic kidney disease
- Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
- Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis
- Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition
Songming Huang
Nanjing Children's Hospital (CN)
4 shared publications
- <scp>LONP1</scp> targets <scp>HMGCS2</scp> to protect mitochondrial function and attenuate chronic kidney disease
- Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
- TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5
- Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition
Xinyue Xu
Nanjing Children's Hospital (CN)
4 shared publications
- Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
- A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis
- TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5
- Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis
Qianqian Jin
Nanjing Medical University (CN)
3 shared publications
- Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
- Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
- TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5
Jiaming Liang
Yale University (US)
3 shared publications
- Nesterov Smoothing for Sampling Without Smoothness
- Nesterov smoothing for sampling without smoothness
- On a Class of Gibbs Sampling over Networks
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