Katherine Deck

Federal Grant PI

Researcher

UAMS

Last publication 2025 Last refreshed 2026-05-22

faculty

4 h-index 28 pubs 92 cited

Research Areas

Links

ORCID

OverviewAI-generated summary

Katherine Deck's research focuses on the immunological mechanisms underlying hypertension, particularly the role of T-lymphocytes and specific molecular pathways in its development and progression. Her work investigates how immune cells, such as CD8+ T-cells, interact with other cellular components and signaling molecules to influence blood pressure regulation. Recent publications explore the contribution of interferon-gamma (IFNγ) and its associated pathways, like PD-L1, to the immune-mediated processes driving hypertension. Additionally, her research examines the function of P2X7 receptors in T-cell activation and their role in promoting salt-sensitive hypertension, a condition exacerbated by high dietary sodium intake.

Deck's investigations extend to the kidney and heart, examining how immune responses in these organs contribute to chronic high blood pressure. Her work has identified kidney-resident memory CD8+ T cells as drivers of sustained hypertension and salt sensitivity. She also studies the transition of macrophages to myofibroblasts, a process influenced by cytokines like IL-10, which promotes fibrosis in the failing heart. Her federally funded work, supported by the NIH/National Heart Lung and Blood Institute, specifically targets the role of kidney-resident memory CD8+ T cells in promoting hypertension and memorizing salt sensitivity. Deck collaborates with researchers at the University of Arkansas for Medical Sciences, including Christoph Mora, Shengyu Mu, Yunping Guo, and Tonya Rafferty.

Metrics

h-index: 4
Publications: 28
Citations: 92

Selected Publications

IL-10 Drives Macrophage to Myofibroblast Transition Promoting Chronic Fibrosis in the Failing Heart 9287 (2025)

DOI OpenAlex
Kidney resident-memory CD8+ T cells drive chronic high blood pressure 9288 (2025)

DOI OpenAlex
Energy Overload: ATP-P2X7-Mediated T Cell Activation in Obesity-Induced Type 2 Diabetes 9286 (2025)

DOI OpenAlex
Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension (2025)

DOI OpenAlex
Uncovering immune pathways for therapeutic targeting of hypertension (2025)

DOI OpenAlex
Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025)

DOI OpenAlex
Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction (2025)

DOI OpenAlex
Establishment of resident memory T cells anchors hypertension in the kidney (2025)

DOI OpenAlex
T Cells Drive Kidney Memory for Hypertension (2024)

DOI OpenAlex
Abstract P200: Immune memory contributes to chronic hypertension recurrence (2024)

DOI OpenAlex
Abstract P335: An innate immune component in hypertension-induced cardiac dysfunction Christoph Mora, Katherine Deck, Yunmeng Liu, Lance Benson, Tonya Rafferty, & Shengyu Mu (2024)

DOI OpenAlex
P227 MACROPHAGE TO MYOFIBROBLAST TRANSITION IN THE DEVELOPMENT OF DIASTOLIC DYSFUNCTION (2024)

DOI OpenAlex
O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION (2024)

DOI OpenAlex
Kidney resident memory CD8 T cells mediate recurrence of salt-sensitive hypertension (2024)

DOI OpenAlex
Macrophage to Myofibroblast Transition Promotes Hypertension-Induced Cardiac Diastolic Dysfunction (2024)

DOI OpenAlex