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Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
K
Katherine S. Deck
Federal Grant PI
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Also affiliated: University of Arkansas Medical Center (2023–2025)
4 h-index
32 pubs
104 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Katherine Deck's research focuses on the immunological mechanisms underlying hypertension, particularly the role of T-lymphocytes and specific molecular pathways in its development and progression. Her work investigates how immune cells, such as CD8+ T-cells, interact with other cellular components and signaling molecules to influence blood pressure regulation. Recent publications explore the contribution of interferon-gamma (IFNγ) and its associated pathways, like PD-L1, to the immune-mediated processes driving hypertension. Additionally, her research examines the function of P2X7 receptors in T-cell activation and their role in promoting salt-sensitive hypertension, a condition exacerbated by high dietary sodium intake.
Deck's investigations extend to the kidney and heart, examining how immune responses in these organs contribute to chronic high blood pressure. Her work has identified kidney-resident memory CD8+ T cells as drivers of sustained hypertension and salt sensitivity. She also studies the transition of macrophages to myofibroblasts, a process influenced by cytokines like IL-10, which promotes fibrosis in the failing heart. Her federally funded work, supported by the NIH/National Heart Lung and Blood Institute, specifically targets the role of kidney-resident memory CD8+ T cells in promoting hypertension and memorizing salt sensitivity. Deck collaborates with researchers at the University of Arkansas for Medical Sciences, including Christoph Mora, Shengyu Mu, Yunping Guo, and Tonya Rafferty.
Metrics
- h-index: 4
- Publications: 32
- Citations: 104
Selected Publications
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Macrophage Plasticity Drives Cardiac Dysfunction in Hypertension 2253031 (2026)
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Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension 2259853 (2026)
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Kidney Resident Memory CD8+ T cells drive the immortality of hypertension (2026)
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Cytokine-mediated macrophage transition promotes early cardiac fibrosis in chronic hypertension (2026)
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IL-10 Drives Macrophage to Myofibroblast Transition Promoting Chronic Fibrosis in the Failing Heart 9287 (2025)
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P2X7 Drives T-cell Activation Promoting Chronic Inflammation During High Blood Pressure 9289 (2025)
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Kidney resident-memory CD8+ T cells drive chronic high blood pressure 9288 (2025)
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Energy Overload: ATP-P2X7-Mediated T Cell Activation in Obesity-Induced Type 2 Diabetes 9286 (2025)
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Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension (2025)
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Uncovering immune pathways for therapeutic targeting of hypertension (2025)
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Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025)
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Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction (2025)
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Establishment of resident memory T cells anchors hypertension in the kidney (2025)
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T Cells Drive Kidney Memory for Hypertension (2024)
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Abstract P200: Immune memory contributes to chronic hypertension recurrence (2024)
Federal Grants 1 $39,509 total
NIH
Contact PI
Sep 2024 - Sep 2026
Kidney-resident memory CD8+ T cells promote hypertension and memorize salt sensitivity.
Collaboration Network
Top Collaborators
Shengyu Mu
University of Arkansas for Medical Sciences
29 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
Showing 5 of 29 shared publications
Christoph Mora
University of Arkansas for Medical Sciences
24 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
Showing 5 of 24 shared publications
Lance Benson
University of Arkansas for Medical Sciences (US)
15 shared publications
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
- Abstract P200: Immune memory contributes to chronic hypertension recurrence
Showing 5 of 15 shared publications
Yunmeng Liu
University of Arkansas for Medical Sciences
15 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- The link between immunity and hypertension in the kidney and heart
- Abstract P200: Immune memory contributes to chronic hypertension recurrence
- S-40-5: ROLE OF INTERFERON GAMMA IN T CELL MEDIATED SALT-RETENTION IN THE KIDNEY AND PROGRESSION OF HYPERTENSION
- Macrophage to Myofibroblast Transition in Diastolic Dysfunction Development
Showing 5 of 15 shared publications
Yunping Guo
University of Arkansas for Medical Sciences
14 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- The link between immunity and hypertension in the kidney and heart
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
- Abstract P200: Immune memory contributes to chronic hypertension recurrence
- S-40-5: ROLE OF INTERFERON GAMMA IN T CELL MEDIATED SALT-RETENTION IN THE KIDNEY AND PROGRESSION OF HYPERTENSION
Showing 5 of 14 shared publications
Tonya Rafferty
University of Arkansas for Medical Sciences
14 shared publications
In database
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Abstract P200: Immune memory contributes to chronic hypertension recurrence
- Uncovering immune pathways for therapeutic targeting of hypertension
- O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION
Showing 5 of 14 shared publications
Shuoqiu Deng
University of Arkansas for Medical Sciences
13 shared publications
In database
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Uncovering immune pathways for therapeutic targeting of hypertension
- Establishment of resident memory T cells anchors hypertension in the kidney
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction
- Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension
Showing 5 of 13 shared publications
Pamela Rogers
University of Arkansas for Medical Sciences
9 shared publications
In database
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction
- Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension
- Energy Overload: ATP-P2X7-Mediated T Cell Activation in Obesity-Induced Type 2 Diabetes 9286
- Kidney resident-memory CD8+ T cells drive chronic high blood pressure 9288
- IL-10 Drives Macrophage to Myofibroblast Transition Promoting Chronic Fibrosis in the Failing Heart 9287
Showing 5 of 9 shared publications
Yunmeng Liu
University of Arkansas for Medical Sciences
8 shared publications
In database
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Uncovering immune pathways for therapeutic targeting of hypertension
- O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION
- Establishment of resident memory T cells anchors hypertension in the kidney
Showing 5 of 8 shared publications
Pamela I. Rogers
University of Arkansas for Medical Sciences
4 shared publications
In database
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Uncovering immune pathways for therapeutic targeting of hypertension
- Establishment of resident memory T cells anchors hypertension in the kidney
- P2X7 Drives T-cell Activation Promoting Chronic Inflammation During High Blood Pressure 9289
Christoph Mora
University of Arkansas for Medical Sciences
4 shared publications
In database
- Cytokine-mediated macrophage transition promotes early cardiac fibrosis in chronic hypertension
- Kidney Resident Memory CD8+ T cells drive the immortality of hypertension
- Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension 2259853
- Macrophage Plasticity Drives Cardiac Dysfunction in Hypertension 2253031
Tonya Rafferty
University of Arkansas for Medical Sciences
4 shared publications
In database
- Cytokine-mediated macrophage transition promotes early cardiac fibrosis in chronic hypertension
- Kidney Resident Memory CD8+ T cells drive the immortality of hypertension
- Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension 2259853
- Macrophage Plasticity Drives Cardiac Dysfunction in Hypertension 2253031
Yunzhao Xiong
University of Arkansas for Medical Sciences (US)
2 shared publications
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- S-40-5: ROLE OF INTERFERON GAMMA IN T CELL MEDIATED SALT-RETENTION IN THE KIDNEY AND PROGRESSION OF HYPERTENSION
Lin‐Xi Li
L-3 Communications (United States)
2 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
Lu Huang
L-3 Communications (United States)
2 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
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