Matthew Bryant

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Supervisory Toxicologist

NCTR

Also affiliated: Human Genome Sciences (United States) (2019); Boston University (1986); Merck & Co., Inc., Rahway, NJ, USA (United States) (2012); Center for Food Safety and Applied Nutrition (1996); Research Triangle Park Foundation (1994–1998); United States Food and Drug Administration (1996–2025); The University of Texas MD Anderson Cancer Center (2019); Jilin University (2013); Washington University in St. Louis (2013); Biochemical Society (2016–2017); Roanoke College (2013); First Hospital of Jilin University (2013); Duke Medical Center (2013); Goodman Research Group (United States) (1986); PharmacoGenetics (China) (1999–2002); Precision BioLogic (Canada) (2023); Baum Consult (1986); Covance (United States) (2004–2005); University of Portsmouth (2013); Massachusetts Institute of Technology (1984–1988)

Faculty Researcher

36 h-index 94 pubs 3,855 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website Research Group

OverviewAI-generated summary

Matthew Bryant's research focuses on toxicology, particularly the genotoxic and cytotoxic effects of various substances in human and animal models. His work investigates the mechanisms by which chemicals can damage DNA and lead to cellular harm. This includes studies on the genotoxicity of compounds like luteolin and nitrosamine impurities, utilizing human lymphoblastoid TK6 cells engineered to express specific cytochrome P450 enzymes, which are involved in chemical metabolism.

Bryant also studies the toxicity of aerosols, such as ortho-phthalaldehyde, using in vitro human airway tissue models. His research extends to the toxicokinetics and genotoxicity of known carcinogens like NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) in Sprague-Dawley rats, examining different routes of exposure including inhalation, intraperitoneal injection, and oral gavage. Additionally, his work includes pharmacokinetic analyses of nicotine and its metabolites in rats following various administration methods.

His scholarship metrics include an h-index of 35, with 94 total publications and over 3,700 citations, designating him as a highly cited researcher. Bryant collaborates with several colleagues at the National Center for Toxicological Research, including Xiaobo He, Nan Mei, Qiangen Wu, and Robert H. Heflich, with whom he has co-authored multiple publications. He leads a research group and maintains an active laboratory website.

Metrics

h-index: 36
Publications: 94
Citations: 3,855

Selected Publications

Mechanistic study of pexidartinib-induced toxicity in human hepatic cells (2025)

Chemico-Biological Interactions 4 citations DOI OpenAlex
Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025)

Chemico-Biological Interactions 5 citations DOI OpenAlex
An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024)

Journal of Environmental Science and Health Part C 2 citations DOI OpenAlex
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)

Toxicological Sciences 8 citations DOI OpenAlex
CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue (2024)

Toxicological Sciences 4 citations DOI OpenAlex
The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)

Frontiers in Pharmacology 2 citations DOI OpenAlex
Evaluation of a microphysiological human placental barrier model for studying placental drug transfer (2023)

Reproductive Toxicology 4 citations DOI OpenAlex
The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)

Toxicological Sciences 15 citations DOI OpenAlex
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023)

Chemical Research in Toxicology 4 citations DOI OpenAlex
Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022)

Archives of Toxicology 29 citations DOI OpenAlex
In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats (2022)

Reproductive Toxicology 4 citations DOI OpenAlex
90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021)

Food and Chemical Toxicology 6 citations DOI OpenAlex
Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021)

Toxicology 6 citations DOI OpenAlex
14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021)

Toxicological Sciences 7 citations DOI OpenAlex
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)

Toxicological Sciences 15 citations DOI OpenAlex