Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-16
Biography and Research Information
OverviewAI-generated summary
Nadine Hempel's research investigates the molecular mechanisms underlying cancer progression and metastasis, with a particular focus on cellular signaling pathways and metabolic adaptations.
Her work has explored the role of mitochondrial calcium uniporters in driving metastasis and conferring dependencies in pancreatic cancer. She has also examined the complex interplay of STIM, Orai, and IP3Rs in mammalian calcium signaling, and the reciprocal regulation of SOX2 by SMAD1-SMAD3 in promoting anoikis resistance and metastasis in cancer. Hempel's research further investigates how mesenchymal stem cells contribute to ovarian cancer heterogeneity and metastasis through mitochondrial transfer, and the metabolic relationships between growth factors in the ovarian cancer ascites environment. Additionally, her studies have addressed the adaptation to anchorage-independence through HuR-dependent SOD2 protein synthesis and the metabolic effects of diet-induced obesity in mice through antisense oligonucleotide-mediated knockdown of Mpzl3.
Hempel holds a faculty position as an Associate Professor at the University of Arkansas for Medical Sciences. Her scholarly output includes 269 publications and 4,959 citations, with an h-index of 39. She has collaborated with Karthikeyan Mythreye on 17 shared publications.
Metrics
- h-index: 39
- Publications: 269
- Citations: 4,959
Selected Publications
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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation (2026)
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The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming (2026)
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Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway (2025)
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ATR promotes mTORC1 activity via de novo cholesterol synthesis (2025)
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Data from Aged and <i>BRCA</i>-Mutated Stromal Cells Drive Epithelial Cell Transformation (2025)
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Crosstalk between calcium and reactive oxygen species signaling in cancer revisited (2025)
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Aged and <i>BRCA</i> -Mutated Stromal Cells Drive Epithelial Cell Transformation (2025)
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Zinc availability in the tumor microenvironment dictates anti-PD1 response in <i>CDKN2A</i> <sup>Low</sup> tumors via increased macrophage phagocytosis (2025)
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Loss of the predicted cell adhesion molecule MPZL3 promotes EMT and chemoresistance in ovarian cancer (2024)
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Stress response regulation of mRNA translation: Implications for antioxidant enzyme expression in cancer (2024)
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Hypomorphic NOTCH1 Expression Alters Cardiomyocyte Cellular Architecture in Hypoplastic Left Heart Syndrome (2024)
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Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production (2024)
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Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression (2024)
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Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer (2024)
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Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production (2024)
Collaboration Network
Top Collaborators
Karthikeyan Mythreye
University of Alabama at Birmingham
17 shared publications
In database
- Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
- Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment
- HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence
- PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance
- Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers
Showing 5 of 17 shared publications
Amal T. Elhaw
16 shared publications
- Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment
- HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence
- Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
- GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15
- Aged and <i>BRCA</i> -Mutated Stromal Cells Drive Epithelial Cell Transformation
Showing 5 of 16 shared publications
Mohamed Trebak
UPMC Hillman Cancer Center (US)
13 shared publications
- Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer
- Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling
- The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation
- A multiple-oscillator mechanism underlies antigen-induced Ca2+ oscillations in Jurkat T-cells
- Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
Showing 5 of 13 shared publications
Katherine M. Aird
13 shared publications
- Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
- GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15
- <i>De Novo</i> Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
- αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation
- ATR promotes mTORC1 activity via <i>de novo</i> cholesterol synthesis
Showing 5 of 13 shared publications
Rébécca Phaëton
Pennsylvania State University (US)
11 shared publications
- Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
- Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
- GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15
- Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF-β signaling responses in ovarian cancer
- Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
Showing 5 of 11 shared publications
Zaineb Javed
University of Pittsburgh (US)
10 shared publications
- HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence
- GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15
- Alternative splice variants of the mitochondrial fission protein <i>DNM1L</i> /Drp1 regulate mitochondrial dynamics and tumor progression in ovarian cancer
- GPX3 supports ovarian cancer tumor progression <i>in vivo</i> and promotes expression of GDF15
- Loss of the predicted cell adhesion molecule MPZL3 promotes EMT and chemoresistance in ovarian cancer
Showing 5 of 10 shared publications
Yeon Kim
Pennsylvania State University (US)
9 shared publications
- HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence
- Stress response regulation of mRNA translation: Implications for antioxidant enzyme expression in cancer
- Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
- Alternative splice variants of the mitochondrial fission protein <i>DNM1L</i> /Drp1 regulate mitochondrial dynamics and tumor progression in ovarian cancer
- SIRT3/SOD2-mediated redox signaling in metastatic ovarian cancer
Showing 5 of 9 shared publications
Priscilla W. Tang
UPMC Hillman Cancer Center (US)
9 shared publications
- Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment
- HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence
- A multiple-oscillator mechanism underlies antigen-induced Ca2+ oscillations in Jurkat T-cells
- GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15
- Crosstalk between calcium and reactive oxygen species signaling in cancer revisited
Showing 5 of 9 shared publications
Naveen Kumar Tangudu
UPMC Hillman Cancer Center (US)
9 shared publications
- <i>De Novo</i> Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
- αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation
- ATR promotes mTORC1 activity via <i>de novo</i> cholesterol synthesis
- Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production
- Zinc availability in the tumor microenvironment dictates anti-PD1 response in <i>CDKN2A</i> <sup>Low</sup> tumors via increased macrophage phagocytosis
Showing 5 of 9 shared publications
Apoorva Uboveja
UPMC Hillman Cancer Center (US)
9 shared publications
- <i>De Novo</i> Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
- αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation
- ATR promotes mTORC1 activity via <i>de novo</i> cholesterol synthesis
- Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production
- Zinc availability in the tumor microenvironment dictates anti-PD1 response in <i>CDKN2A</i> <sup>Low</sup> tumors via increased macrophage phagocytosis
Showing 5 of 9 shared publications
J. Cory Benson
UPMC Hillman Cancer Center (US)
8 shared publications
- The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation
- A multiple-oscillator mechanism underlies antigen-induced Ca2+ oscillations in Jurkat T-cells
- Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
- Crosstalk between calcium and reactive oxygen species signaling in cancer revisited
- Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
Showing 5 of 8 shared publications
Nam Y. Lee
University of Arizona (US)
8 shared publications
- Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
- Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers
- Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
- Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF-β signaling responses in ovarian cancer
- Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation
Showing 5 of 8 shared publications
Nathaniel W. Snyder
Temple University (US)
8 shared publications
- <i>De Novo</i> Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
- αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation
- ATR promotes mTORC1 activity via <i>de novo</i> cholesterol synthesis
- Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production
- Zinc availability in the tumor microenvironment dictates anti-PD1 response in <i>CDKN2A</i> <sup>Low</sup> tumors via increased macrophage phagocytosis
Showing 5 of 8 shared publications
Mehri Monavarian
University of Alabama at Birmingham (US)
7 shared publications
- Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
- Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment
- PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance
- Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
- PVT1, a YAP1 dependent stress responsive lncRNA drives ovarian cancer metastasis and chemoresistance
Showing 5 of 7 shared publications
Rebecca C. Arend
University of Alabama (US)
7 shared publications
- Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
- Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment
- PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance
- Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF-β signaling responses in ovarian cancer
- Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
Showing 5 of 7 shared publications
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