Biography and Research Information
OverviewAI-generated summary
Nadine Hempel's research focuses on the molecular mechanisms underlying cancer metastasis and cellular signaling pathways. Her work investigates how cellular components and signaling molecules contribute to the progression and spread of various cancers, including ovarian and pancreatic cancers. She has published research exploring the role of the mitochondrial calcium uniporter in driving metastasis and conferring dependencies in pancreatic cancer cells. Additionally, her work has examined the complex regulation of calcium signaling by various proteins, including STIM, Orai, and IP3Rs, across mammalian systems.
Hempel's research also delves into the reciprocal regulation of gene expression in cancer, specifically the interplay between SOX2 and SMAD proteins, which is crucial for anoikis resistance and metastasis in cancer. Her investigations extend to the microenvironment of cancer, including the role of carcinoma-associated mesenchymal stem cells in promoting ovarian cancer heterogeneity and metastasis through mitochondrial transfer. Her scholarship metrics include an h-index of 39, with over 270 publications and more than 4,900 citations.
Metrics
- h-index: 39
- Publications: 269
- Citations: 4,959
Selected Publications
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Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway (2025)
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ATR promotes mTORC1 activity via de novo cholesterol synthesis (2025)
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Data from Aged and <i>BRCA</i>-Mutated Stromal Cells Drive Epithelial Cell Transformation (2025)
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Crosstalk between calcium and reactive oxygen species signaling in cancer revisited (2025)
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Aged and <i>BRCA</i> -Mutated Stromal Cells Drive Epithelial Cell Transformation (2025)
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Zinc availability in the tumor microenvironment dictates anti-PD1 response in <i>CDKN2A</i> <sup>Low</sup> tumors via increased macrophage phagocytosis (2025)
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Loss of the predicted cell adhesion molecule MPZL3 promotes EMT and chemoresistance in ovarian cancer (2024)
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Stress response regulation of mRNA translation: Implications for antioxidant enzyme expression in cancer (2024)
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Hypomorphic NOTCH1 Expression Alters Cardiomyocyte Cellular Architecture in Hypoplastic Left Heart Syndrome (2024)
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Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production (2024)
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Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression (2024)
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Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer (2024)
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Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production (2024)
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Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation (2024)
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<i>De Novo</i> Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression (2024)
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