Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
N
Nükhet Aykin‐Burns
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Associate Professor
Also affiliated: University of Iowa (2004–2013); Atkins (United States) (2018); Arkansas Children's Hospital (2017); Missouri University of Science and Technology (2002–2006); Central Arkansas Veterans Healthcare System (2014); Winthrop Rockefeller Foundation (2015); ORCID (2021); Onco Lille (2009); Pharmaceutical Biotechnology (Czechia) (2024); Arkansas Department of Health (2018); University of Iowa Holden Comprehensive Cancer Center (2006–2009); University of Pennsylvania (2021)
Faculty Researcher
36 h-index
113 pubs
7,516 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Nükhet Aykin‐Burns' research focuses on understanding the mechanisms of bone loss and the impact of various stressors on cellular function, particularly within osteoclasts and ovaries. Her work investigates the role of mitochondrial sirtuin 3 (Sirt3) in age-related and estrogen deficiency-induced bone loss. She has also explored how transferrin receptor 1-mediated iron uptake influences bone mass in mice by affecting osteoclast mitochondria and cytoskeleton. Further investigations examine the effects of ionizing radiation and simulated galactic cosmic rays on mitochondrial metabolism in osteoclasts, leading to bone loss. Aykin‐Burns also studies chemotherapy-induced oxidative stress in the ovary, examining drug-dependent mechanisms and potential interventions. Her research extends to the cellular mechanisms of ferroptosis in hepatocellular carcinoma cells, specifically how parthenolide induces thiol oxidation. Additionally, she has investigated the role of microRNA-2392 in SARS-CoV-2 infection and the protective effects of curcumin against acrolein-induced alveolar epithelial apoptosis.
Metrics
- h-index: 36
- Publications: 113
- Citations: 7,516
Selected Publications
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Assessing Pain Linked to High Metabolic and Glycolytic Shift in Neurofibromatosis Type 1 (NF1) Patients by Using a Bioenergetic Biomarker: A Pilot Study (2026)
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Abstract LB219: Proteomic signatures of doxorubicin-induced lymphatic dysfunction in tumor-bearing rats (2026)
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SIRT3–IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025)
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Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure (2025)
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Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025)
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SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity (2023)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)
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Abstract 2839: Methionine restriction radiosensitizes KRAS mutant rectal cancer (2023)
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Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model (2023)
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Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, And Cognition in an Aged Murine Model (2022)
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Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, and Cognition in an Aged Murine Model (2022)
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Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022)
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Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions (2022)
Collaboration Network
Top Collaborators
Kimberly J. Krager
University of Arkansas for Medical Sciences
19 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
Showing 5 of 19 shared publications
Francesca V. LoBianco
University of Arkansas for Medical Sciences
7 shared publications
In database
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity
- Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model
- Abstract No. 584 Parthenolide induces thiol oxidation inducing ferroptosis in human hepatocellular carcinoma cells
- Overcoming the Restricted Therapy Options and Monitoring Challenges in Metastatic Breast Cancer
Showing 5 of 7 shared publications
Ha‐Neui Kim
University of Arkansas for Medical Sciences
6 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
- Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure
Showing 5 of 6 shared publications
Kimberly Richardson
University of Arkansas for Medical Sciences (US)
5 shared publications
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
- Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure
Wen Ling
University of Arkansas for Medical Sciences
4 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Antiño R. Allen
University of Arkansas for Medical Sciences
4 shared publications
In database
- Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model
Aaron Warren
University of Arkansas for Medical Sciences
3 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
- Hem1 promotes osteoclast fusion and bone resorption in mice
Maria Almeida
University of Arkansas for Medical Sciences
3 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
- Hem1 promotes osteoclast fusion and bone resorption in mice
Bhaba Krishna Das
Southern California Institute for Research and Education (US)
3 shared publications
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
Toshifumi Fujiwara
University of Arkansas for Medical Sciences (US)
3 shared publications
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
Renny S. Lan
University of Arkansas for Medical Sciences
3 shared publications
In database
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
3 shared publications
In database
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
Ricky D. Edmondson
University of Arkansas for Medical Sciences
3 shared publications
In database
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
Michael L. Jennings
University of Arkansas for Medical Sciences
3 shared publications
In database
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
Xiaofang Wang
Texas A&M University (US)
3 shared publications
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
Similar Researchers
Based on overlapping research topics
Kimberly J. Krager
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Mitochondrial Function and Pathology
Iron Metabolism and Disorders
Elena Ambrogini
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
SARS-CoV-2 and COVID-19 Research
Cancer Cells and Metastasis
Logan Waddle
University of Arkansas at Fayetteville
Mitochondrial Function and Pathology
Cancer Cells and Metastasis
Jacob Kordsmeier
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Mitochondrial Function and Pathology
Aaron Warren
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Mitochondrial Function and Pathology
Maria Almeida
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Mitochondrial Function and Pathology