Nükhet Aykin‐Burns Data-verified

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Associate Professor

University of Arkansas UAMS primary

Last publication 2026 Last refreshed 2026-05-23

faculty

36 h-index 112 pubs 7,383 cited

Research Areas

Links

ORCID Google Scholar Research Group

OverviewAI-generated summary

Nükhet Aykin‐Burns' research focuses on the biological mechanisms underlying bone loss, aging, and the impact of oxidative stress on cellular function. She investigates the role of mitochondria, specifically Sirtuin 3 (Sirt3), in age-related and estrogen deficiency-induced bone loss, as well as the effects of ionizing radiation and simulated galactic cosmic rays on osteoclast function and bone integrity in mice. Her work also explores how iron uptake through the transferrin receptor 1 influences bone mass by affecting osteoclast mitochondria and cytoskeleton. Aykin‐Burns has examined chemotherapy-induced oxidative stress in the ovary and its potential interventions, and the mechanisms of ferroptosis in hepatocellular carcinoma cells induced by parthenolide. She also studies the role of curcumin in mitigating acrolein-induced alveolar epithelial apoptosis through Keap1 cysteine conjugation. Aykin‐Burns leads a research group and has a significant publication record with 111 publications and over 7,281 citations, achieving an h-index of 36. She has a network of key collaborators at the University of Arkansas for Medical Sciences, including Kimberly J. Krager, Francesca V. LoBianco, Ha‐Neui Kim, and Brian Koss, with whom she has co-authored numerous publications.

Metrics

h-index: 36
Publications: 112
Citations: 7,383

Selected Publications

SIRT3–IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025)

DOI OpenAlex
Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure (2025)

1 citation DOI OpenAlex
Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025)

DOI OpenAlex
SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025)

DOI OpenAlex
Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)

9 citations DOI OpenAlex
The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity (2023)

10 citations DOI OpenAlex
466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)

DOI OpenAlex
Abstract 2839: Methionine restriction radiosensitizes KRAS mutant rectal cancer (2023)

DOI OpenAlex
Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model (2023)

9 citations DOI OpenAlex
Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, And Cognition in an Aged Murine Model (2022)

DOI OpenAlex
Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, and Cognition in an Aged Murine Model (2022)

DOI OpenAlex
Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022)

5 citations DOI OpenAlex
Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions (2022)

19 citations DOI OpenAlex
Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells (2022)

17 citations DOI OpenAlex
Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton (2022)

2 citations DOI OpenAlex