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OverviewAI-generated summary
Prasanth Viswanathan's research focuses on the molecular mechanisms underlying cancer, particularly lymphomas associated with the Kaposi's sarcoma-associated herpesvirus (KSHV). His work investigates the role of anti-apoptotic BCL2 family members, such as MCL1, in the survival of these transformed cells. Viswanathan has published studies demonstrating how the expression ratios of these proteins dictate the selective dependence of KSHV-transformed primary effusion lymphoma cell lines on MCL1 for survival. Further research explores the involvement of mitochondrial ubiquitin ligases, like MARCHF5, in cooperating with MCL1 to inhibit apoptosis in these cell lines. Additionally, his work includes investigating the impact of gene suppression, such as TRIP13, on metabolic changes and ferroptosis induction in multiple myeloma. Viswanathan collaborates with researchers at the University of Arkansas for Medical Sciences, including Mark Manzano, Daniel Dunham, and Jackson Gill, on these investigations.
Metrics
- h-index: 1
- Publications: 4
- Citations: 3
Selected Publications
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The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines (2024)
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Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma (2023)
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Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1 (2022)
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Expression Ratios of the Anti-Apoptotic BCL2 Family Members Dictate the Selective Addiction of KSHV-Transformed Primary Effusion Lymphoma Cell Lines to MCL1 (2022)
Collaboration Network
Top Collaborators
Mark Manzano
University of Arkansas for Medical Sciences
4 shared publications
In database
- Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
- Expression Ratios of the Anti-Apoptotic BCL2 Family Members Dictate the Selective Addiction of KSHV-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
- The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines
Daniel Dunham
Winthrop Rockefeller Foundation
3 shared publications
In database
- Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
- Expression Ratios of the Anti-Apoptotic BCL2 Family Members Dictate the Selective Addiction of KSHV-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
- The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines
Jackson Gill
Winthrop Rockefeller Foundation
3 shared publications
In database
- Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
- Expression Ratios of the Anti-Apoptotic BCL2 Family Members Dictate the Selective Addiction of KSHV-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
- The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines
Yan Cheng
Winthrop Rockefeller Foundation (US)
1 shared publication
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Fumou Sun
Winthrop Rockefeller Foundation
1 shared publication
In database
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Wancheng Guo
Winthrop Rockefeller Foundation (US)
1 shared publication
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Hongwei Xu
Winthrop Rockefeller Foundation (US)
1 shared publication
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Eric R. Siegel
University of Arkansas for Medical Sciences
1 shared publication
In database
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Samer Al Hadidi
University of Arkansas for Medical Sciences
1 shared publication
In database
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Carolina Schinke
University of Arkansas for Medical Sciences
1 shared publication
In database
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Maurizio Zangari
University of Arkansas for Medical Sciences
1 shared publication
In database
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Marta Chesi
Mayo Clinic in Arizona (US)
1 shared publication
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
P. Leif Bergsagel
Mayo Clinic in Arizona (US)
1 shared publication
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Frits van Rhee
Winthrop Rockefeller Foundation
1 shared publication
In database
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Guido Tricot
Winthrop Rockefeller Foundation
1 shared publication
In database
- Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma
Similar Researchers
Based on overlapping research topics
Daniel Dunham
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Mark Manzano
University of Arkansas for Medical Sciences
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Allison C. Farrar
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Y. Q. Tang
University of Arkansas at Fayetteville
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