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Biography and Research Information
OverviewAI-generated summary
Megan R. Reed investigates CAR-T cell therapies for solid tumors, particularly focusing on glioblastoma. Her work includes developing functional precision medicine pipelines that combine comparative transcriptomics and tumor organoid modeling to identify tailored treatment strategies. Reed has also explored the anti-glioblastoma activity of specific compounds in organoid models and investigated the role of tryptophan 2,3-dioxygenase inhibition in DNA damage tolerance and repair in glioma cells. Additionally, her research has involved the genetic encoding of photocaged amino acids for light-controlled protein activity and the development of genetically encoded biosensors for antibiotic biosynthesis.
Reed collaborates with researchers at the University of Arkansas for Medical Sciences, including Robert L. Eoff, Billie Heflin, Brian Koss, and Daniel Fil, with whom she has co-authored multiple publications. Her scholarship metrics include an h-index of 15, 45 total publications, and 659 total citations.
Metrics
- h-index: 15
- Publications: 47
- Citations: 688
Selected Publications
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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Abstract 1488: DNA polymerase kappa slows replication fork speed by promoting fork reversal in glioblastoma (2025)
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1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024)
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538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024)
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Abstract 1333 DNA polymerase kappa (Pol k) promotes replication gap suppression by preventing PrimPol mediated repriming and safeguards genomic stability in Glioblastoma Multiforme (GBM) (2024)
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Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity (2024)
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536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma (2023)
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Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma (2023)
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CAR-T Therapies in Solid Tumors: Opportunities and Challenges (2023)
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CAR T-cells to treat brain tumors (2023)
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Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer (2022)
Collaboration Network
Top Collaborators
Robert L. Eoff
University of Arkansas for Medical Sciences
15 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
Showing 5 of 15 shared publications
Billie Heflin
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
Showing 5 of 13 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
12 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
Showing 5 of 12 shared publications
Brian Koss
University of Arkansas for Medical Sciences
9 shared publications
In database
- CAR-T Therapies in Solid Tumors: Opportunities and Challenges
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
Showing 5 of 9 shared publications
Analiz Rodriguez
University of Arkansas Medical Center
8 shared publications
In database
- CAR-T Therapies in Solid Tumors: Opportunities and Challenges
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- CAR T-cells to treat brain tumors
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Showing 5 of 8 shared publications
Daniel Fil
University of Arkansas for Medical Sciences
8 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 8 shared publications
Alicja Urbaniak
Cancer Institute (WIA)
7 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
Showing 5 of 7 shared publications
Timothy C. Chambers
University of Arkansas for Medical Sciences
7 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
Showing 5 of 7 shared publications
Leena Maddukuri
University of Arkansas for Medical Sciences
6 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Showing 5 of 6 shared publications
Adam Huczyński
Adam Mickiewicz University in Poznań (PL)
6 shared publications
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Angus M. MacNicol
University of Arkansas for Medical Sciences
6 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Amit Ketkar
University of Arkansas for Medical Sciences
5 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Jacob L Edmondson
University of Arkansas for Medical Sciences
5 shared publications
In database
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells
- 691 ATF6 activation promotes ICB response in melanoma
Justin Leung
University of Arkansas for Medical Sciences (US)
4 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Melanie C MacNicol
University of Arkansas for Medical Sciences
4 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
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