Biography and Research Information
OverviewAI-generated summary
Billie Heflin's research at the University of Arkansas for Medical Sciences investigates the anti-cancer properties of various natural compounds and therapeutic agents, with a focus on melanoma and glioblastoma. Recent publications explore the in vitro anti-melanoma activity of the Trametes versicolor mushroom and the anti-glioblastoma effects of monensin and its analogs in an organoid model. Further work examines the mechanisms by which specific genetic modifications and compounds influence cancer cell apoptosis and antigen presentation, including CRISPR/dCas9-KRAB-mediated suppression of S100b to restore p53-mediated apoptosis in melanoma cells, and the role of resveratrol in enhancing major histocompatibility complex class I antigen presentation. Heflin also studies the impact of EZH2 inhibition on CAR-T cell persistence and the synthesis and anti-melanoma activity of novel acryloyl pyridinone analogues. Collaborations include work with Megan R. Reed, Brian Koss, Alan J. Tackett, and Daniel Fil.
Metrics
- h-index: 4
- Publications: 20
- Citations: 67
Selected Publications
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024)
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538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024)
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Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity (2024)
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Synthesis and Anti‐Melanoma Activity of Acryloyl Pyridinone Analogues (2023)
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536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma (2023)
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Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023)
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Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma (2023)
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CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells (2023)
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The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro (2023)
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Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer (2022)
Collaboration Network
Top Collaborators
Alan J. Tackett
University of Arkansas for Medical Sciences
16 shared publications
In database
- The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Synthesis and Anti‐Melanoma Activity of Acryloyl Pyridinone Analogues
Showing 5 of 16 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
Showing 5 of 13 shared publications
Brian Koss
University of Arkansas for Medical Sciences
10 shared publications
In database
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
Showing 5 of 10 shared publications
Alicja Urbaniak
Cancer Institute (WIA)
8 shared publications
In database
- The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- Synthesis and Anti‐Melanoma Activity of Acryloyl Pyridinone Analogues
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
Showing 5 of 8 shared publications
Daniel Fil
University of Arkansas for Medical Sciences
8 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 8 shared publications
Timothy C. Chambers
University of Arkansas for Medical Sciences
6 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Nathan L. Avaritt
University of Arkansas for Medical Sciences
6 shared publications
In database
- The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Synthesis and Anti‐Melanoma Activity of Acryloyl Pyridinone Analogues
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 6 shared publications
Jacob L Edmondson
University of Arkansas for Medical Sciences
5 shared publications
In database
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells
- 691 ATF6 activation promotes ICB response in melanoma
Marta Jędrzejczyk
Adam Mickiewicz University in Poznań (PL)
4 shared publications
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Greta Klejborowska
Adam Mickiewicz University in Poznań (PL)
4 shared publications
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Natalia Stępczyńska
Adam Mickiewicz University in Poznań (PL)
4 shared publications
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Adam Huczyński
Adam Mickiewicz University in Poznań (PL)
4 shared publications
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Robert L. Eoff
University of Arkansas for Medical Sciences
4 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Angus M. MacNicol
University of Arkansas for Medical Sciences
4 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Katherine Wallis
University of Arkansas for Medical Sciences
4 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 691 ATF6 activation promotes ICB response in melanoma
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
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