Ricky D. Edmondson
High Impact
Professor
faculty
Biochemistry & Molecular Biology, College of Medicine
32 h-index
91 pubs
4,540 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Ricky D. Edmondson, Professor in the Department of Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences, leads a research group investigating molecular mechanisms underlying cellular processes, with a particular focus on gene regulation and cancer development. His work has explored how phase separation influences chromatin looping and contributes to tumorigenesis. Edmondson also investigates the role of specific proteins and complexes, such as TNRC18 and BAHD1, in mediating gene silencing and the regulation of endogenous retrotransposons.
Further research by Edmondson examines the function of the transferrin receptor 1 in iron uptake and its regulation of bone mass in mice, involving osteoclast mitochondria and the cytoskeleton. His publications also delve into the identification of regulatory axes in advanced prostate cancer, utilizing cistrome analysis to uncover interactions between transcription factors like YY1 and key regulatory proteins. Edmondson's research group has a strong network of collaborators within the University of Arkansas for Medical Sciences, including Samuel G. Mackintosh, Alan J. Tackett, Aaron J. Storey, and Dr. Stephanie Byrum, with whom he has co-authored multiple publications.
With an h-index of 32 and over 4,400 citations from 90 publications, Edmondson is recognized as a highly cited researcher. His work contributes to a deeper understanding of fundamental biological processes with implications for disease mechanisms, particularly in oncology and bone metabolism.
Metrics
- h-index: 32
- Publications: 91
- Citations: 4,540
Selected Publications
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Multiplexed Detection of Membranous Nephropathy Antigens by Multi-Reaction Monitoring Mass Spectrometry. (2026)
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Abstract 6079: Resistance-specific proteogenomics in melanoma PDXs (2026)
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Proteomic Profiling of Complement Components in Glomerular Disease (2026)
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
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Anthrax toxins exacerbate sepsis-induced coagulopathy and endothelial dysfunction in a baboon model of anthrax (2025)
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Multiplexed Detection of Membranous Antigens by Mass Spectrometry (2025)
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YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7 (2025)
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Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis (2025)
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The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators (2025)
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Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis (2025)
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Dynamic global acetylation remodeling during the yeast heat shock response (2025)
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319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024)
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TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons (2023)
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304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors (2023)
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Characterization of methionine dependence in melanoma cells (2023)
Grants & Funding
- Identification of Druggable Targets to Complement Melanoma Therapy NIH Co-Investigator
- Development of biomarkers for improved classification of proliferative lupus nephritis NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Arkana Laboratories Co-Investigator
- Role of HELB in the Replication Stress Response Dr. Tacketts COBRA through ACRI NIH/Nat. Inst. of General Medical Sciences - Pass Through: Arkansas Children's Research Institute Co-Investigator
- Biomarkers of Early Renal Functional Decline in Type 2 Diabetes NIH Co-Investigator
- IDeA National Resource for Quantitative Proteomics NIH Co-Investigator
- Development of a Precision Medicine-Based Diagnostic Tool for Membranous Nephropathy NIH/National Institutes of Health - Pass Through: Arkana Laboratories Principal Investigator
- Discovery and Characterization of Novel Sepsis Proteome Biomarkers NIH Co-Investigator
Collaboration Network
Top Collaborators
Samuel G. Mackintosh
University of North Carolina at Chapel Hill
15 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Showing 5 of 15 shared publications
Alan J. Tackett
12 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 12 shared publications
Aaron J. Storey
University of North Carolina at Chapel Hill
11 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 11 shared publications
Stephanie D. Byrum
11 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 11 shared publications
Ling Cai
10 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 10 shared publications
Gang Greg Wang
10 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 10 shared publications
Yiran Guo
Duke University (US)
6 shared publications
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
Weida Gong
5 shared publications
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
Chenxi Xu
5 shared publications
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Yi‐Hsuan Tsai
University of North Carolina at Chapel Hill (US)
4 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Deyou Zheng
4 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Huitao Fan
University of North Carolina at Chapel Hill (US)
4 shared publications
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
Phillip M. Galbo
University of North Carolina at Chapel Hill (US)
3 shared publications
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Jeong Hyun Ahn
Seoul National University (KR)
3 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
Arum Kim
University of North Carolina at Chapel Hill (US)
3 shared publications
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
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