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Presence
Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-06
S
Sumit Sarkar
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Also affiliated: Tufts University (2002–2004); Boston Children's Hospital (2009); Tufts Medical Center (2001–2005); United States Food and Drug Administration (2010–2026); Rashtrasant Tukadoji Maharaj Nagpur University (1999–2001); Harvard University (2009); Indiana University Indianapolis (2005–2007); Indiana University School of Medicine (2005–2017); Indiana University – Purdue University Indianapolis (2008)
35 h-index
107 pubs
4,392 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Sumit Sarkar's research focuses on neurological disorders, particularly Alzheimer's disease, and its underlying mechanisms. His work has investigated the role of metals in Alzheimer's disease progression and explored methods for in vivo demonstration of amyloid plaques in rat models. Sarkar has also examined the role of astrocytes in the glymphatic network, a critical system for waste clearance in the brain. His research extends to understanding sex-related neuropathology and cognitive deficits in mouse models of Alzheimer's disease, and he has explored the connection between Alzheimer's disease and type 3 diabetes, with a specific interest in African American populations.
Additionally, Sarkar's research has addressed broader neurotoxicity, including quantitative analysis of rat brain toxicity following exposure to trimethyltin. He has also contributed to the development and characterization of methods for localizing plaques and tangles in both rodent and human brain tissue, employing techniques such as Congo Red labeling and modified K114 staining. His work is supported by collaborations with researchers at the National Center for Toxicological Research, including James Raymick, Serguei Liachenko, Merle G. Paule, and E. Ellen Jones. Sarkar is a highly cited researcher with an h-index of 35 and over 111 publications.
Metrics
- h-index: 35
- Publications: 107
- Citations: 4,392
Selected Publications
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A new method for visualizing cerebrovascular vessels (2026)
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Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease (2025)
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Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease (2025)
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The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses (2024)
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Evaluation and Characterization of Modified K114 Method to Localize Plaques in Rodent and Plaques and Tangles in Human Brain Tissue (2024)
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In vivo mapping of rat brain partial white matter content using hexachlorophene-induced neurotoxicity model (2024)
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A novel humanized Tau‐FAD mice represent a robust model for studying AD‐related dysfunction (2023)
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The role of astrocytes in the glymphatic network: a narrative review (2023)
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Combining tissue clearing and Fluoro-Jade C labeling for neurotoxicity assessments (2023)
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Assessment of sex-related neuropathology and cognitive deficits in the Tg-SwDI mouse model of Alzheimer’s disease (2022)
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Development of early biomarkers of Alzheimer's disease: A precision medicine perspective (2022)
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Evaluation of Styrylbenzene analog- FSB and its affinity to bind parenchymal plaques and tangles in patients of Alzheimer’s disease (2022)
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Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity (2021)
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Role of metals in Alzheimer’s disease (2021)
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Alzheimer’s disease: a step closer to understanding type 3 diabetes in African Americans (2021)
Collaboration Network
Top Collaborators
James Raymick
National Center for Toxicological Research
29 shared publications
In database
- Neuroprotective and Therapeutic Strategies against Parkinson’s Disease: Recent Perspectives
- Role of metals in Alzheimer’s disease
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Downregulation of 14-3-3 Proteins in Alzheimer’s Disease
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
Showing 5 of 29 shared publications
Joseph P. Hanig
Center for Drug Evaluation and Research (US)
24 shared publications
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Microglial activation and responses to vasculature that result from an acute LPS exposure
- Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson’s disease mouse model: Endothelial and microglial effects
- The use of MRI to assist the section selections for classical pathology assessment of neurotoxicity
Showing 5 of 24 shared publications
Merle G. Paule
National Center for Toxicological Research
19 shared publications
In database
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- The use of MRI to assist the section selections for classical pathology assessment of neurotoxicity
- Protein Kinases and Parkinson’s Disease
- Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage
Showing 5 of 19 shared publications
Elvis Cuevas
National Center for Toxicological Research (US)
15 shared publications
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Downregulation of 14-3-3 Proteins in Alzheimer’s Disease
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Amyloid Beta 25–35 induces blood-brain barrier disruption in vitro
- Protein Kinases and Parkinson’s Disease
Showing 5 of 15 shared publications
Larry Schmued
National Center for Toxicological Research (US)
14 shared publications
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Neurotoxicity of Ecstasy (MDMA): An Overview
- Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's Disease model
- Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies
- The use of MRI to assist the section selections for classical pathology assessment of neurotoxicity
Showing 5 of 14 shared publications
Héctor Rosas-Hernández
National Center for Toxicological Research
12 shared publications
In database
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Amyloid Beta 25–35 induces blood-brain barrier disruption in vitro
- Protein Kinases and Parkinson’s Disease
- Modification of methods to use Congo-red stain to simultaneously visualize amyloid plaques and tangles in human and rodent brain tissue sections
- Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer’s Disease
Showing 5 of 12 shared publications
Bonnie Robinson
National Center for Toxicological Research
10 shared publications
In database
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson’s disease mouse model: Endothelial and microglial effects
- Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer’s Disease
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
Showing 5 of 10 shared publications
Syed F. Ali
National Center for Toxicological Research
9 shared publications
In database
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Amyloid Beta 25–35 induces blood-brain barrier disruption in vitro
- Protein Kinases and Parkinson’s Disease
- Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage
- Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-l-carnitine
Showing 5 of 9 shared publications
Serguei Liachenko
National Center for Toxicological Research
9 shared publications
In database
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- The use of MRI to assist the section selections for classical pathology assessment of neurotoxicity
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
- Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat
- Quantitative Neurotoxicology: An Assessment of the Neurotoxic Profile of Kainic Acid in Sprague Dawley Rats
Showing 5 of 9 shared publications
Sherry A. Ferguson
National Center for Toxicological Research (US)
9 shared publications
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's Disease model
- Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
- Increased inflammation in BA21 brain tissue from African Americans with Alzheimer’s disease
Showing 5 of 9 shared publications
Qiang Gu
National Center for Toxicological Research
8 shared publications
In database
- Downregulation of 14-3-3 Proteins in Alzheimer’s Disease
- Downregulation of 14-3-3 Proteins in a Kainic Acid-Induced Neurotoxicity Model
- One-step labeling of degenerative neurons in unfixed brain tissue samples using Fluoro-Jade C
- ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson’s Disease
- In vitro detection of cytotoxicity using FluoroJade-C
Showing 5 of 8 shared publications
Syed Z. Imam
National Center for Toxicological Research
7 shared publications
In database
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Amyloid Beta 25–35 induces blood-brain barrier disruption in vitro
- Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
- Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier
Showing 5 of 7 shared publications
John F. Bowyer
National Center for Toxicological Research
7 shared publications
In database
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Microglial activation and responses to vasculature that result from an acute LPS exposure
- Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
- Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine
- Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency
Showing 5 of 7 shared publications
Srinivasulu Chigurupati
United States Food and Drug Administration (US)
6 shared publications
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity
- The use of MRI to assist the section selections for classical pathology assessment of neurotoxicity
- Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease
Showing 5 of 6 shared publications
Susan M. Lantz
National Center for Toxicological Research
5 shared publications
In database
- Protein Kinases and Parkinson’s Disease
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
- Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier
- In vitro detection of cytotoxicity using FluoroJade-C
- Ontogeny of Second Messenger Systems
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