Sung W. Rhee
Professor
Also affiliated: University of Vermont (2010); National Institutes of Health (2012); The University of Texas MD Anderson Cancer Center (2019); University of Kansas (2014); Heidelberg University (2012); University of Arkansas Medical Center (2008–2015); National Institute of Environmental Health Sciences (2012); The University of Kansas Cancer Center (2014); University of Kansas Medical Center (2014); Kaiser Permanente Bernard J. Tyson School of Medicine (2022–2024); The University of Texas Medical Branch at Galveston (2019); Saarland University (2012)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Sung W. Rhee's research has focused on the mechanisms of hypertension and platelet function in hemostasis. His work investigates the role of the IFNγ-PDL1 pathway in promoting hypertension through CD8T-DCT interaction. Additionally, Rhee studies the structural evolution of thrombi in venous puncture wounds, examining how platelet capture and activation at the wound site contribute to hemostasis. His publications detail the use of advanced electron microscopy techniques to characterize platelet activation states and thrombus formation. Rhee has a history of collaboration with researchers at the University of Arkansas for Medical Sciences, including Irina D. Pokrovskaya, Brian Storrie, and Kelly K. Ball. His scholarly output includes 90 publications with 997 citations and an h-index of 17.
Metrics
- h-index: 16
- Publications: 74
- Citations: 945
Positions
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Professor publications 2005–2026University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment (2026)
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The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis (2025)
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Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats (2024)
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Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation (2024)
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Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site (2023)
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Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi (2022)
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Hypertension Induces Contractile Dysfunction in Rat Mesenteric Lymph Vessels (2022)
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The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension (2022)
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Combined use of serial block face SEM and focused ion beam SEM elucidates the 3D ultrastructure of blood platelets and thrombi (2022)
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Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model (2021)
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Interactive retrieval practice in renal physiology improves performance on customized National Board of Medical Examiners examination of medical students (2021)
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Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates (2021)
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Mechanisms of Increased Infarct Volume in a Rat Model of Ischemic Stroke: Implications for Leptomeningeal Collateral Artery Function and Beta Blocker Therapy (2021)
Collaboration Network
Top Collaborators
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Protein Kinase A–Phosphorylated K V 1 Channels in PSD95 Signaling Complex Contribute to the Resting Membrane Potential and Diameter of Cerebral Arteries
- Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
- Loss of cerebrovascularShaker-type K+channels: a shared vasodilator defect of genetic and renal hypertensive rats
- Intracellular Ca2+Silences L-Type Ca2+Channels in Mesenteric Veins
Showing 5 of 29 shared publications
- The Steady‐State Distribution of Glycosyltransferases Between the Golgi Apparatus and the Endoplasmic Reticulum is Approximately 90:10
- Capacity of the Golgi Apparatus for Cargo Transport Prior to Complete Assembly
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
Showing 5 of 14 shared publications
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
Showing 5 of 12 shared publications
- Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches
- Loss of cerebrovascularShaker-type K+channels: a shared vasodilator defect of genetic and renal hypertensive rats
- Postsynaptic density‐95 scaffolding of Shaker‐type K+ channels in smooth muscle cells regulates the diameter of cerebral arteries
- Beta1-Adrenergic Receptor-Mediated Dilation of Rat Cerebral Artery Requires Shaker -Type K V 1 Channels on PSD95 Scaffold
- β1 adrenergic receptor‐initiated dilation in rat cerebral arteries is mediated by Shaker ‐type K V 1 channels and is attenuated in angiotensin II‐induced hypertension
Showing 5 of 10 shared publications
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Intracellular Ca2+Silences L-Type Ca2+Channels in Mesenteric Veins
- BK Channels in Rat and Human Pulmonary Smooth Muscle Cells are BKα‐β1 Functional Complexes Lacking the Oxygen‐Sensitive Stress Axis Regulated Exon Insert
- The β3 subunit: a key regulator of vascular calcium channel expression (1057.10)
- Targeting the high‐conductance Ca2+‐activated K+ (BK) channel as vasodilator therapy for pulmonary hypertension
Showing 5 of 10 shared publications
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Metoprolol Impairs β1-Adrenergic Receptor-Mediated Vasodilation in Rat Cerebral Arteries: Implications for β-Blocker Therapy
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
- Mechanisms of Increased Infarct Volume in a Rat Model of Ischemic Stroke: Implications for Leptomeningeal Collateral Artery Function and Beta Blocker Therapy
Showing 5 of 10 shared publications
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Platelet Activation State Intermixing in a Venous Puncture Model Indicates Novel Patterns of Thrombus Formation
Showing 5 of 8 shared publications
- Using a Facebook group to facilitate faculty-student interactions during preclinical medical education: a retrospective survey analysis
- Metoprolol Impairs β1-Adrenergic Receptor-Mediated Vasodilation in Rat Cerebral Arteries: Implications for β-Blocker Therapy
- Mechanisms of Increased Infarct Volume in a Rat Model of Ischemic Stroke: Implications for Leptomeningeal Collateral Artery Function and Beta Blocker Therapy
- Using a Facebook Group to Facilitate Faculty-Student Interactions during Preclinical Medical Education: a Retrospective Survey Analysis
- Oral Metoprolol Attenuates Dilation of Leptomeningeal Collateral Arteries after Middle Cerebral Artery Occlusion and Increases Infarct Volume in Sprague Dawley Rats
Showing 5 of 8 shared publications
- Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches
- Protein Kinase A–Phosphorylated K V 1 Channels in PSD95 Signaling Complex Contribute to the Resting Membrane Potential and Diameter of Cerebral Arteries
- Beta1-Adrenergic Receptor-Mediated Dilation of Rat Cerebral Artery Requires Shaker -Type K V 1 Channels on PSD95 Scaffold
- Metoprolol Impairs β1-Adrenergic Receptor-Mediated Vasodilation in Rat Cerebral Arteries: Implications for β-Blocker Therapy
- PSD95 scaffolding of the Shaker ‐type K + channel enables PKA‐dependent phosphorylation and vasodilation of cerebral arteries (1057.7)
Showing 5 of 7 shared publications
- Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Intracellular Ca2+Silences L-Type Ca2+Channels in Mesenteric Veins
- Postsynaptic density‐95 scaffolding of Shaker‐type K+ channels in smooth muscle cells regulates the diameter of cerebral arteries
- L‐type Ca 2+ (Ca L ) Channels are Silent During Depolarization of Venous Smooth Muscle
Showing 5 of 7 shared publications
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Platelet Activation State Intermixing in a Venous Puncture Model Indicates Novel Patterns of Thrombus Formation
Showing 5 of 7 shared publications
- Protein Kinase A–Phosphorylated K V 1 Channels in PSD95 Signaling Complex Contribute to the Resting Membrane Potential and Diameter of Cerebral Arteries
- Beta1-Adrenergic Receptor-Mediated Dilation of Rat Cerebral Artery Requires Shaker -Type K V 1 Channels on PSD95 Scaffold
- PSD95 scaffolding of the Shaker ‐type K + channel enables PKA‐dependent phosphorylation and vasodilation of cerebral arteries (1057.7)
- Properties of the high‐conductance Ca 2+ ‐activated K + (BK) channel in pulmonary arterial smooth muscle cells (847.3)
- K V 1 channel‐mediated dilation to isoproterenol in cerebral arteries is disrupted in angiotensin II ‐induced hypertension
Showing 5 of 6 shared publications
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- The β3 subunit: a key regulator of vascular calcium channel expression (1057.10)
- Abnormalities of Vascular Ion Channels During Hypertension
- α1‐Adrenergic receptor (α1‐AR) activation rapidly upregulates L‐type Ca2+ channels in rat mesenteric arteries in vivo
- Dynamic turnover of L‐type calcium channels in rat mesenteric arteries in vivo
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
- The β3 subunit: a key regulator of vascular calcium channel expression (1057.10)
- α1‐Adrenergic receptor (α1‐AR) activation rapidly upregulates L‐type Ca2+ channels in rat mesenteric arteries in vivo
- Dynamic turnover of L‐type calcium channels in rat mesenteric arteries in vivo
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment
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