Ugochi H. Isu Data-verified

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

University of Arkansas

Last publication 2024 Last refreshed 2026-04-01

faculty

5 h-index 16 pubs 89 cited

Research Areas

Links

ORCID Lab Website

OverviewAI-generated summary

Ugochi H. Isu's research investigates the conformational dynamics of proteins, particularly focusing on their roles in biological processes and disease mechanisms. Isu has published work comparing the conformational changes of the SARS-CoV-2 spike protein to that of SARS-CoV-1, and has explored the dynamics of the cannabinoid receptor 1 in its active and inactive states. Additional research includes examining the influence of cholesterol on class C G protein-coupled receptors and metabotropic glutamate receptor 1, as well as studying the alternating access mechanism in multidrug resistance transporters. Isu collaborates with several researchers at the University of Arkansas at Fayetteville, including Mahmoud Moradi and Adithya Polasa, with whom they have co-authored multiple publications. Their work utilizes molecular dynamics simulations to understand these complex molecular behaviors.

Metrics

h-index: 5
Publications: 16
Citations: 89

Selected Publications

Differential Behavior of Conformational Dynamics in Active and Inactive States of Cannabinoid Receptor 1 (2024)

4 citations DOI OpenAlex
Differential Behavior of Conformational Dynamics in Active and Inactive States of Cannabinoid Receptor 1 (2024)

DOI OpenAlex
Cholesterol Dependence of the Conformational Changes in Metabotropic Glutamate Receptor 1 (2024)

1 citation DOI OpenAlex
Cholesterol-regulated conformational dynamics and stability of mGluR2 embedded in detergent micelles: Insights from molecular dynamics (2024)

DOI OpenAlex
Differential behavior of conformational dynamics in active and inactive states of cannabinoid receptor 1 revealed by microsecond molecular dynamics simulation (2024)

DOI OpenAlex
The Alternating Access Mechanism in Mammalian Multidrug Resistance Transporters and Their Bacterial Homologs (2023)

17 citations DOI OpenAlex
Cholesterol in Class C GPCRs: Role, Relevance, and Localization (2023)

24 citations DOI OpenAlex
Cholesterol dependence on the conformational changes of metabotropic glutamate receptor 1 (mGLuR1) (2023)

DOI OpenAlex
Cholesterol in Class C GPCRs: Role, Relevance, and Localization (2023)

6 citations DOI OpenAlex
Prefusion spike protein conformational changes are slower in SARS-CoV-2 than in SARS-CoV-1 (2022)

26 citations DOI OpenAlex
Characterizing the roles of chemo-mechanical couplings in the differential behavior of SARS-CoV-1 and SARS-CoV-2 spike glycoprotein (2022)

DOI OpenAlex
Structural dynamics of prefusion spike protein of SARS-CoV-2 and its variants (2022)

DOI OpenAlex
Differential Dynamic Behavior of Prefusion Spike Glycoproteins of Sars Coronaviruses 1 and 2 (2021)

DOI OpenAlex
Comparing the Dynamic Differences between X-ray and Cryo-EM Structures of Cannabinoid Receptor 1 using Molecular Dynamics Simulations (2021)

2 citations DOI OpenAlex