Ugochi H. Isu Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

University of Arkansas at Fayetteville

faculty

5 h-index 16 pubs 84 cited

Research Areas

Protein Structure and Dynamics Neuroscience and Neuropharmacology Research Cannabis and Cannabinoid Research Molecular Biology Techniques and Applications Diet and metabolism studies

Links

ORCID Lab Website

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Ugochi H. Isu's research focuses on the conformational dynamics of membrane proteins, particularly focusing on G protein-coupled receptors (GPCRs) and multidrug resistance transporters. Her work investigates the role of cholesterol in the function and localization of Class C GPCRs, such as metabotropic glutamate receptor 1 and cannabinoid receptor 1. Isu utilizes molecular dynamics simulations to compare structural dynamics between different states of these receptors and to analyze differences observed in X-ray and Cryo-EM structures. This research contributes to understanding the complex mechanisms underlying receptor function and drug interactions. Isu has collaborated with researchers including Mahmoud Moradi, Adithya Polasa, Shadi A. Badiee, and Vivek Govind Kumar at the University of Arkansas at Fayetteville, with whom she has co-authored multiple publications. Her scholarly output includes 16 publications and has been cited 84 times, with an h-index of 5.

Metrics

  • h-index: 5
  • Publications: 16
  • Citations: 84

Selected Publications

  • Differential Behavior of Conformational Dynamics in Active and Inactive States of Cannabinoid Receptor 1 (2024) DOI
  • Differential Behavior of Conformational Dynamics in Active and Inactive States of Cannabinoid Receptor 1 (2024) DOI
  • Cholesterol Dependence of the Conformational Changes in Metabotropic Glutamate Receptor 1 (2024) DOI
  • Cholesterol-regulated conformational dynamics and stability of mGluR2 embedded in detergent micelles: Insights from molecular dynamics (2024) DOI
  • Differential behavior of conformational dynamics in active and inactive states of cannabinoid receptor 1 revealed by microsecond molecular dynamics simulation (2024) DOI
  • The Alternating Access Mechanism in Mammalian Multidrug Resistance Transporters and Their Bacterial Homologs (2023) DOI
  • Cholesterol in Class C GPCRs: Role, Relevance, and Localization (2023) DOI
  • Cholesterol dependence on the conformational changes of metabotropic glutamate receptor 1 (mGLuR1) (2023) DOI
  • Prefusion spike protein conformational changes are slower in SARS-CoV-2 than in SARS-CoV-1 (2022) DOI
  • Characterizing the roles of chemo-mechanical couplings in the differential behavior of SARS-CoV-1 and SARS-CoV-2 spike glycoprotein (2022) DOI
  • Structural dynamics of prefusion spike protein of SARS-CoV-2 and its variants (2022) DOI
  • Differential Dynamic Behavior of Prefusion Spike Glycoproteins of Sars Coronaviruses 1 and 2 (2021) DOI
  • Comparing the Dynamic Differences between X-ray and Cryo-EM Structures of Cannabinoid Receptor 1 using Molecular Dynamics Simulations (2021) DOI

Collaborators

Researchers in the database who share publications

Mahmoud Moradi University of Arkansas at Fayetteville 8 shared publications Adithya Polasa University of Arkansas at Fayetteville 8 shared publications Shadi A. Badiee University of Arkansas at Fayetteville 5 shared publications Vivek Govind Kumar University of Arkansas at Fayetteville 4 shared publications Mortaza Derakhshani-Molayousefi University of Arkansas at Fayetteville 4 shared publications Ehsaneh Khodadadi University of Arkansas at Fayetteville 4 shared publications Dylan S. Ogden University of Arkansas at Fayetteville 2 shared publications James Losey University of Arkansas at Fayetteville 2 shared publications

Similar Researchers

Based on overlapping research topics

Olusoji A. T. Afuwape University of Arkansas for Medical Sciences
Protein Structure and Dynamics Neuroscience and Neuropharmacology Research Molecular Biology Techniques and Applications
Strong match 3 shared topics
Alejandro Ramirez-Lee National Center for Toxicological Research
Protein Structure and Dynamics Neuroscience and Neuropharmacology Research Molecular Biology Techniques and Applications
Good match 3 shared topics
Aída Guzmán National Center for Toxicological Research
Protein Structure and Dynamics Neuroscience and Neuropharmacology Research Molecular Biology Techniques and Applications
Good match 3 shared topics
LaFreda J. Howard University of Arkansas at Fayetteville
Protein Structure and Dynamics Neuroscience and Neuropharmacology Research Molecular Biology Techniques and Applications
Good match 3 shared topics
Ashley Herdman University of Arkansas for Medical Sciences
Protein Structure and Dynamics Neuroscience and Neuropharmacology Research Molecular Biology Techniques and Applications
Good match 4 shared topics
Paavan Atluri University of Arkansas at Fayetteville
Protein Structure and Dynamics Neuroscience and Neuropharmacology Research Molecular Biology Techniques and Applications
Good match 3 shared topics