W. Sue T. Griffin

Federal Grant PI High Impact

Professor

UAMS

Last publication 2025 Last refreshed 2026-05-22

faculty

Geriatrics, College of Medicine

66 h-index 173 pubs 17,510 cited

Research Areas

Links

ORCID Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

W. Sue T. Griffin's research investigates the molecular mechanisms underlying neurodegenerative diseases, with a significant focus on Alzheimer's disease and glioblastoma. Her work explores the roles of specific proteins, cytokines, and microbial factors in disease pathogenesis and potential therapeutic targets. Griffin has published research on the involvement of Porphyromonas gingivalis outer membrane vesicles in Alzheimer's neuropathogenesis, the impact of APOEε4 genetics and neuroinflammation on Alzheimer's disease, and the potential of thiadiazolidinone (TDZD) analogs to inhibit aggregation-related pathology in neurodegeneration models. She also studies the role of the proinflammatory cytokine IL-1β in glioblastoma, examining the therapeutic effects of IL-1β receptor antagonist and Tolcapone. Her recent work also delves into lysosomal autophagic failure in Alzheimer's disease and the potential for small molecule rescue, as well as the role of glial fibrillary acidic protein as a biomarker and drug target for Alzheimer's disease. Further investigations include the proteome of Caenorhabditis elegans mitochondria in relation to aging and Alzheimer's disease.

Metrics

h-index: 66
Publications: 173
Citations: 17,510

Selected Publications

Abstract LB320: Inverse relationship between cancer and Alzheimer’s disease: Important interplay between autophagy and apoptosis signaling mechanisms (2026)

DOI OpenAlex
The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease (2026)

DOI OpenAlex
When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025)

1 citation DOI OpenAlex
The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025)

2 citations DOI OpenAlex
Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology (2025)

DOI OpenAlex
Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025)

1 citation DOI OpenAlex
Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023)

12 citations DOI OpenAlex
Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease (2022)

42 citations DOI OpenAlex
Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease (2021)

1 citation DOI OpenAlex
Porphyromonas gingivalis Outer Membrane Vesicles as the Major Driver of and Explanation for Neuropathogenesis, the Cholinergic Hypothesis, Iron Dyshomeostasis, and Salivary Lactoferrin in Alzheimer’s Disease (2021)

56 citations DOI OpenAlex

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Federal Grants 2 $1,058,437 total

NIH/National Institute on Aging Contact PI May 2023 - Jan 2028

Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue

National Institute on Aging $470,331 R01

NIH/NIH Office of the Director Co-PI Jun 2017 - Nov 2022

The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction

NIH Office of the Director $588,106 U01

Grants & Funding

GENE EXPRESSION IN BRAIN CELLS IN AIDS NIH Principal Investigator
Early Events in Alzheimer Pathogenesis NIH Principal Investigator
CYTOKINES, NEURODEGENERATION AND DOWN'S SYNDROME NIH Principal Investigator
Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue NIH/Nat. Inst. on Aging Principal Investigator
BRAIN DEVELOPMENT AND GRAFT VERSUS HOST DISEASE NIH Principal Investigator
Compromised function of a glial glucose transporter in aging and Alzheimer's disease NIH Co-Investigator
Amyloid Precursor Protein and Ubiquitination NIH/Nat. Inst. on Aging Co-Investigator
Center for Translational Neuroscience NIH Co-Investigator