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Biography and Research Information
OverviewAI-generated summary
Y. Lucy Liu's research focuses on the molecular mechanisms underlying inherited bone marrow failure syndromes and leukemias. Her work has investigated the role of nemo-like kinase activation in Diamond-Blackfan anemia, specifically its suppression of erythropoiesis through interference with mitochondrial biogenesis. Liu has also explored the inflammatory pathways and bone marrow microenvironment in inherited bone marrow failure syndromes. In the area of juvenile myelomonocytic leukemia (JMML), her research includes the development of novel mouse models, such as a humanized loss-of-function *NF1* model, and the epigenetic profiling of PTPN11 mutant JMML hematopoietic stem and progenitor cells. Her studies have also examined the sensitivity of JMML stem cells to NK cell-mediated lysis and identified potential targetable antigens. Liu has published 28 papers with 558 citations and an h-index of 8. She collaborates with Peter D. Emanuel at the University of Arkansas for Medical Sciences, with whom she shares 2 publications.
Metrics
- h-index: 8
- Publications: 28
- Citations: 558
Selected Publications
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Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens (2025)
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Sustained fetal hematopoiesis causes juvenile death from leukemia: evidence from a dual-age–specific mouse model (2020)
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PTEN is indispensable for cells to respond to MAPK inhibitors in myeloid leukemia (2018)
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The Dosage of Pten Is Critical in Determining the Disease Severity - a Mouse Model Differentially Mimicking JMML and CMML (2016)
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JQ1, a Potential Therapeutic Molecule for Myeloid Leukemia with PTEN Deficiency (2016)
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Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice (2016)
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The genomic landscape of juvenile myelomonocytic leukemia (2015)
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Timing of the Loss of Pten Is Critical in Determining the Disease Phenotype in Mice- a Mouse Model for Pediatric Mixed MDS/MPN (2014)
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Subclonal Mutations in SETBP1 Predict Relapse in Juvenile Myelomonocytic Leukemia (2014)
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Opposite Effects of M1 and M2 Macrophages on Hematopoietic Stem Cell Self-Renewal and Ex Vivo Expansion (2014)
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Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: A report from the Children's Oncology Group (2014)
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Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia (2014)
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Mutations in GATA2 are rare in juvenile myelomonocytic leukemia (2014)
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Mutations In GATA2 Are Rare In Juvenile Myelomonocytic Leukemia (2013)
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Overexpression Of DNMT3a and DNMT3b Is Related To Downregulation Of Mir-29a In Juvenile Myelomonocytic Leukemia (JMML) (2013)
Collaboration Network
Top Collaborators
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
- Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
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