Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
Samuel G. Mackintosh
High Impact
Professor
Also affiliated: University of Rome Tor Vergata (2016); Arkansas Children's Hospital (2024); University of California, Los Angeles (2022); University of Arkansas Medical Center (2015–2020); University of Arkansas System (2020); Abterra Biosciences (United States) (2018–2020); Quantitative BioSciences (2025); Central Arkansas Veterans Healthcare System (2016); Winthrop Rockefeller Foundation (2016–2022); Arkansas Department of Agriculture (2014–2020)
Faculty Researcher
Biochemistry & Molecular Biology, College of Medicine
37 h-index
158 pubs
4,656 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Samuel G. Mackintosh serves as Professor in the Department of Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences (UAMS) and holds leadership roles as Managing Director of the IDeA National Resource for Quantitative Proteomics and Co-Director of the UAMS WP Rockefeller Cancer Institute Proteomics Shared Resource. With nearly two decades of experience, he specializes in the operation and maintenance of nanoflow liquid chromatography mass spectrometry (MS) systems, including various Thermo Orbitrap models. Mackintosh collaborates with principal investigators to apply MS technology to their research, assisting with project planning, sample preparation, instrument operation, and data analysis using software such as Mascot, MaxQuant, Scaffold, and Spectronaut.
His research group's work has contributed to nearly 50 publications in the last five years. His scholarly output includes 147 publications with 4,586 citations, resulting in an h-index of 37. Mackintosh is recognized as a highly cited researcher. Key collaborators include Alan J. Tackett, Aaron J. Storey, Stephanie D. Byrum, and Ricky D. Edmondson, all from UAMS, with whom he has co-authored numerous publications.
Metrics
- h-index: 37
- Publications: 158
- Citations: 4,656
Selected Publications
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Human gastric extracellular matrix hydrogels maintain organoid growth and reduce gene expression associated with stemness and inflammation (2026)
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Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats (2026)
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Additional file 2 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 2 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 5 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 5 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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A method utilizing chemical carcinogens and a Western diet to reliably induce advanced hepatocellular carcinoma in male and female mice (2026)
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Abstract 6079: Resistance-specific proteogenomics in melanoma PDXs (2026)
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A new chemical carcinogen and Western diet protocol to reliably induce advanced hepatocellular carcinoma in male and female mice (2026)
Grants & Funding
As listed on this researcher's institutional profile.
- HCV NS3: Biological, Biochemical and Structural Analysis NIH Co-Investigator
- Single molecule nucleic acid enzymology NIH Co-Investigator
- Orbitrap Fusion Tribrid Mass Spectrometer NIH Principal Investigator
- Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer NIH/Office of the Director Principal Investigator
- Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer NIH Principal Investigator
- IDeA National Resource for Quantitative Proteomics NIH Co-Investigator
Collaboration Network
Top Collaborators
Stephanie D. Byrum
University of Arkansas for Medical Sciences
32 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Showing 5 of 32 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
24 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 24 shared publications
Aaron J. Storey
Arkana Laboratories
19 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 19 shared publications
Ricky D. Edmondson
University of Arkansas for Medical Sciences
12 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Showing 5 of 12 shared publications
Ling Cai
Duke University (US)
10 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 10 shared publications
Gang Greg Wang
10 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 10 shared publications
Rick D. Edmondson
University of Arkansas for Medical Sciences
10 shared publications
In database
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Characterization of methionine dependence in melanoma cells
- Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis
- Characterization of methionine dependence in melanoma cells
Showing 5 of 10 shared publications
Charity L. Washam
University of Arkansas for Medical Sciences
8 shared publications
In database
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- PHF19 inhibition as a therapeutic target in multiple myeloma
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
Showing 5 of 8 shared publications
Weida Gong
University of North Carolina at Chapel Hill (US)
6 shared publications
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
Yi‐Hsuan Tsai
University of North Carolina at Chapel Hill (US)
6 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
Yiran Guo
Duke University (US)
6 shared publications
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
Stephanie D. Byrum
Arkansas Children's Hospital
6 shared publications
In database
- Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis
- Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
- <i>BRCA1</i> influences whole body metabolism in humanized mice
- Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling
Showing 5 of 6 shared publications
Renny S. Lan
Arkansas Children's Nutrition Center
5 shared publications
In database
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
Nathan L. Avaritt
University of Arkansas for Medical Sciences
5 shared publications
In database
- Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
Kanishka Manna
University of Arkansas for Medical Sciences
4 shared publications
In database
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
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