Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
Jason Scott Stumhofer
Federal Grant PI
High Impact
Associate Professor
Also affiliated: University of Pennsylvania (2006–2012)
Microbiology & Immunology, College of Medicine
27 h-index
55 pubs
5,529 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Jason Scott Stumhofer's research focuses on the immunobiology of T helper cells, particularly the regulation of T helper 17 (Th17) cells and their role in inflammation and host defense. He has investigated the effects of cytokines such as Interleukin-27 (IL-27) and Interleukin-6 (IL-6) on T cell differentiation and function. His work has demonstrated that IL-27 can negatively regulate Th17 cell development and inhibit the production of IL-17, a key cytokine involved in inflammatory responses. Additionally, his research has explored how IL-27 and IL-6 can induce STAT3-mediated production of Interleukin-10 (IL-10) by T cells, suggesting complex regulatory networks within the immune system.
Stumhofer's federally funded research includes projects investigating the regulation of macrophage function during acute infection with Plasmodium, the parasite responsible for malaria. He has also received funding for the development of an organoid model to study the pathogenesis of endemic Burkitt lymphoma and for the design of a B cell tetramer to track Plasmodium falciparum MSP2-specific B cells. These grants highlight his engagement with infectious diseases and cancer biology.
With a career marked by high citation counts and active research, Stumhofer leads a research group at the University of Arkansas for Medical Sciences. His scholarship metrics include an h-index of 26 and over 5,450 citations across 54 publications. He collaborates with several researchers at his institution, including Enatha Ntirandekura, Kara A. O’Neal, Camille L. Foscue, and Susie L. Brown.
Metrics
- h-index: 27
- Publications: 55
- Citations: 5,529
Positions
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Associate Professor 2011–presentUniversity of Arkansas for Medical Sciences Microbiology & Immunology, College of Medicine Institutional directory
Selected Publications
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Early enhanced control of Plasmodium yoelii infection in IL-10-deficient mice is independent of IFN-γ, IL-12, and the humoral response (2026)
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Early enhanced control of Plasmodium yoelii infection in IL-10–deficient mice is independent of IFN-γ, IL-12, and the humoral response (2026)
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Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment (2025)
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Bhlhe40 limits early IL-10 production from CD4 + T cells during Plasmodium yoelii 17X infection (2023)
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IgM+ and IgM– memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon rechallenge with P. yoelii (2022)
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Towards rainbow portable Cytophone with laser diodes for global disease diagnostics (2022)
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ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection (2022)
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ICOS expression is required for maintenance but not the formation of germinal centers in the spleen in response to P. yoelii infection (2021)
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IgM + and IgM - memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon re-challenge with P. yoelii (2021)
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p53 Controls Murine Gammaherpesvirus Latency and Prevents Infection-Associated IgH/c-Myc Translocations (2020)
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ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS (2020)
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ICOS expression is not required for memory T cell formation or maintenance, but does promote Tfh cell differentiation and the humoral response after secondary Plasmodium chabaudi chabaudi AS infection (2019)
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The Immunobiology of the Interleukin-12 Family: Room for Discovery (2019)
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Investigating the Role of C/Ebpδ-Deficiency in Radiation-Induced Bone Marrow Failure (2018)
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NK1.1 Expression Defines a Population of CD4+ Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection (2018)
Federal Grants 3 $336,449 total
NIH
Contact PI
Jul 2026 - Jun 2028
Development of an organoid model for studying endemic Burkitt lymphoma pathogenesis
NIH
Contact PI
Jun 2024 - Apr 2026
Regulation of macrophage function during acute infection with Plasmodium
NIH
Contact PI
Nov 2021 - Oct 2023
Design of a B cell tetramer to track PfMSP2-specific B cells
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Stumhofer Start up Account UAMS College of Medicine Principal Investigator
- A protective role for IL-17 in blood-stage malaria NIH Principal Investigator
- Multicolor Photoacoustic Malaria Detector NIH Co-Investigator
- Understanding the contribution of atypical B cell progenitors to the humoral response NIH Principal Investigator
- Regulation and function of B cells during malaria infection- Resubmission NIH Principal Investigator
- Defining mechanisms of gammaherpesvirus-driven genomic instability in B cells NIH Co-Investigator
Collaboration Network
Top Collaborators
Daniel J. Wikenheiser
University of Pittsburgh (US)
8 shared publications
- ICOS Co-Stimulation: Friend or Foe?
- The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection
- ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS
- NK1.1 Expression Defines a Population of CD4+ Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection
- An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice
Showing 5 of 8 shared publications
Debopam Ghosh
University of Arkansas for Medical Sciences
6 shared publications
In database
- The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection
- Do You See What I See: Recognition of Protozoan Parasites by Toll-Like Receptors
- An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice
- IL-17 Promotes Differentiation of Splenic LSK− Lymphoid Progenitors into B Cells following Plasmodium yoelii Infection
- Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment
Showing 5 of 6 shared publications
Dmitry A. Nedosekin
University of Arkansas for Medical Sciences
4 shared publications
In database
- In vivo photoacoustic flow cytometry for early malaria diagnosis
- Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery
- Towards rainbow portable Cytophone with laser diodes for global disease diagnostics
- Towards early in vivo photoacoustic malaria diagnosis with 10,000-fold sensitivity improvement (Conference Presentation)
Yulian A. Menyaev
University of Arkansas for Medical Sciences
4 shared publications
In database
- In vivo photoacoustic flow cytometry for early malaria diagnosis
- Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery
- Towards rainbow portable Cytophone with laser diodes for global disease diagnostics
- Towards early in vivo photoacoustic malaria diagnosis with 10,000-fold sensitivity improvement (Conference Presentation)
Mustafa Sarimollaoglu
University of Arkansas for Medical Sciences
4 shared publications
In database
- In vivo photoacoustic flow cytometry for early malaria diagnosis
- Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery
- Towards rainbow portable Cytophone with laser diodes for global disease diagnostics
- Towards early in vivo photoacoustic malaria diagnosis with 10,000-fold sensitivity improvement (Conference Presentation)
Vladimir P. Zharov
Arkansas Department of Agriculture
4 shared publications
In database
- In vivo photoacoustic flow cytometry for early malaria diagnosis
- Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery
- Towards rainbow portable Cytophone with laser diodes for global disease diagnostics
- Towards early in vivo photoacoustic malaria diagnosis with 10,000-fold sensitivity improvement (Conference Presentation)
Susie L. Brown
University of Arkansas for Medical Sciences
4 shared publications
In database
- NK1.1 Expression Defines a Population of CD4+ Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection
- IgM+ and IgM– memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon rechallenge with P. yoelii
- IL-17 Promotes Differentiation of Splenic LSK− Lymphoid Progenitors into B Cells following Plasmodium yoelii Infection
- IgM + and IgM - memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon re-challenge with P. yoelii
Leah E. Latham
University of Arkansas for Medical Sciences
4 shared publications
In database
- ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS
- ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection
- ICOS expression is required for maintenance but not the formation of germinal centers in the spleen in response to P. yoelii infection
- ICOS expression is not required for memory T cell formation or maintenance, but does promote Tfh cell differentiation and the humoral response after secondary Plasmodium chabaudi chabaudi AS infection
Enatha Ntirandekura
University of Arkansas for Medical Sciences
4 shared publications
In database
- IgM+ and IgM– memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon rechallenge with P. yoelii
- ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection
- IgM + and IgM - memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon re-challenge with P. yoelii
- ICOS expression is required for maintenance but not the formation of germinal centers in the spleen in response to P. yoelii infection
Kara A. O’Neal
University of Arkansas for Medical Sciences
4 shared publications
In database
- ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection
- Bhlhe40 limits early IL-10 production from CD4 + T cells during Plasmodium yoelii 17X infection
- ICOS expression is required for maintenance but not the formation of germinal centers in the spleen in response to P. yoelii infection
- Early enhanced control of Plasmodium yoelii infection in IL-10-deficient mice is independent of IFN-γ, IL-12, and the humoral response
Christopher A. Hunter
South University (US)
3 shared publications
- The Immunobiology of the Interleukin-12 Family: Room for Discovery
- Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza
- IL-21 Is Required for Optimal Antibody Production and T Cell Responses during Chronic Toxoplasma gondii Infection
Kai A. Carey
University of Arkansas for Medical Sciences (US)
3 shared publications
- In vivo photoacoustic flow cytometry for early malaria diagnosis
- Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery
- Towards early in vivo photoacoustic malaria diagnosis with 10,000-fold sensitivity improvement (Conference Presentation)
Ekaterina I. Galanzha
University of Arkansas for Medical Sciences
3 shared publications
In database
- In vivo photoacoustic flow cytometry for early malaria diagnosis
- Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery
- Towards early in vivo photoacoustic malaria diagnosis with 10,000-fold sensitivity improvement (Conference Presentation)
Juhyung Lee
University of Arkansas for Medical Sciences
3 shared publications
In database
- NK1.1 Expression Defines a Population of CD4+ Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection
- IgM+ and IgM– memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon rechallenge with P. yoelii
- IgM + and IgM - memory B cells represent heterogeneous populations capable of producing class-switched antibodies and germinal center B cells upon re-challenge with P. yoelii
Camille L. Foscue
University of Arkansas for Medical Sciences
3 shared publications
In database
- ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection
- Bhlhe40 limits early IL-10 production from CD4 + T cells during Plasmodium yoelii 17X infection
- ICOS expression is required for maintenance but not the formation of germinal centers in the spleen in response to P. yoelii infection
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