Match tier
Likely match
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
R
Roberta A. Mittelstaedt
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Role not yet determined Is this you? Add your title
Also affiliated: United States Food and Drug Administration (1991–2025); Medizinische Hochschule Hannover (1975)
24 h-index
63 pubs
1,626 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Roberta A. Mittelstaedt's research focuses on the mutagenicity and genotoxicity of chemical substances, employing a range of in vitro and in vivo models. Her work investigates the mechanisms by which compounds can induce genetic damage, utilizing assays such as the CometChip, Duplex Sequencing, and the Ames test to assess DNA damage and mutagenesis.
Mittelstaedt has published studies examining the genotoxicity of specific compounds, including N-nitrosamines and N-nitroso propranolol, and has explored methods for optimizing their detection. Her research also extends to evaluating dose-response relationships for genotoxicity in different life stages and target tissues, as demonstrated by her work with ethyl methane sulfonate. She has investigated toxicokinetic and genotoxicity profiles following various exposure routes, such as inhalation, injection, and oral gavage, in rodent models like Sprague Dawley rats.
Her collaborators at the National Center for Toxicological Research include Robert H. Heflich, Nan Mei, Xuefei Cao, and Joseph G. Shaddock. Mittelstaedt's scholarship metrics include an h-index of 25, with 64 total publications and 1,732 total citations. She is recognized as a highly cited researcher.
Metrics
- h-index: 24
- Publications: 63
- Citations: 1,626
Selected Publications
-
Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2025)
-
Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024)
-
Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
-
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
-
Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021)
-
Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing (2021)
-
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
-
Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking (2021)
-
CD59 ‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in thePig‐agene (2020)
-
Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2019)
-
Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene (2019)
-
Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays (2018)
-
Factors affecting thein vitromicronucleus assay for evaluation of nanomaterials (2016)
-
Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats (2015)
-
Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt‐delta transgenic mice (2014)
Collaboration Network
Top Collaborators
Robert H. Heflich
National Center for Toxicological Research
43 shared publications
In database
- Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- Induction of 6‐thioguanine‐resistant lymphocytes in fischer 344 rats following in vivo exposure to n‐ethyl‐n‐nitrosourea and cyclophosphamide
- Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: II. Selection of Pig‐A mutant rat spleen T‐cells with proaerolysin and sequencing Pig‐A cDNA from the mutants
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
Showing 5 of 43 shared publications
Vasily N. Dobrovolsky
National Center for Toxicological Research
17 shared publications
In database
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: II. Selection of Pig‐A mutant rat spleen T‐cells with proaerolysin and sequencing Pig‐A cDNA from the mutants
- Genotoxicity of furan in Big Blue rats
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Evaluation of Macaca mulatta as a model for genotoxicity studies
Showing 5 of 17 shared publications
Joseph G. Shaddock
National Center for Toxicological Research
16 shared publications
In database
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of furan in Big Blue rats
- Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines
- Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
Showing 5 of 16 shared publications
Mugimane G. Manjanatha
National Center for Toxicological Research
11 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
Showing 5 of 11 shared publications
Anane Aidoo
National Center for Toxicological Research (US)
9 shared publications
- Induction of 6‐thioguanine‐resistant lymphocytes in fischer 344 rats following in vivo exposure to n‐ethyl‐n‐nitrosourea and cyclophosphamide
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Effect of caloric restriction on Hprt lymphocyte mutation in aging rats
- DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene
Showing 5 of 9 shared publications
Frederick A. Beland
National Center for Toxicological Research
9 shared publications
In database
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- 4‐Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice
- Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine
- Comparison of hprt and lacI mutant frequency with DNA adduct formation in N‐hydroxy‐2‐acetylaminofluorene–treated Big Blue® rats†
- Analysis of mutations in the Tk gene of Tk+/− mice treated as neonates with 3′-azido-3′-deoxythymidine (AZT)
Showing 5 of 9 shared publications
Mason G. Pearce
National Center for Toxicological Research
8 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt‐delta transgenic mice
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
Showing 5 of 8 shared publications
Daniel A. Casciano
National Center for Toxicological Research (US)
7 shared publications
- Induction of 6‐thioguanine‐resistant lymphocytes in fischer 344 rats following in vivo exposure to n‐ethyl‐n‐nitrosourea and cyclophosphamide
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
- Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens
- Comparison of hprt and lacI mutant frequency with DNA adduct formation in N‐hydroxy‐2‐acetylaminofluorene–treated Big Blue® rats†
Showing 5 of 7 shared publications
Suzanne M. Morris
National Center for Toxicological Research (US)
6 shared publications
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine
Showing 5 of 6 shared publications
Michelle E. Bishop
National Center for Toxicological Research
6 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Effect of caloric restriction on Hprt lymphocyte mutation in aging rats
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
Showing 5 of 6 shared publications
Nan Mei
National Center for Toxicological Research
6 shared publications
In database
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
Showing 5 of 6 shared publications
Daishiro Miura
Teijin (Japan) (JP)
6 shared publications
- Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: II. Selection of Pig‐A mutant rat spleen T‐cells with proaerolysin and sequencing Pig‐A cDNA from the mutants
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- Analysis of mutations in the Pig‐a gene of spleen T‐cells from N‐ethyl‐N‐nitrosourea‐treated fisher 344 rats
- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
Showing 5 of 6 shared publications
Xuefei Cao
National Center for Toxicological Research
5 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
- Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt‐delta transgenic mice
- In Vivo cII, gpt, and Spi− Gene Mutation Assays in Transgenic Mice and Rats
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
Sharon D. Shelton
National Center for Toxicological Research
5 shared publications
In database
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Gene‐ and tissue‐specificity of mutation in Big Blue® rats treated with the hepatocarcinogen N‐hydroxy‐2‐acetylaminofluorene†
- In Vivo cII, gpt, and Spi− Gene Mutation Assays in Transgenic Mice and Rats
Lascelles E. Lyn‐Cook
National Center for Toxicological Research
5 shared publications
In database
- Induction of 6‐thioguanine‐resistant lymphocytes in fischer 344 rats following in vivo exposure to n‐ethyl‐n‐nitrosourea and cyclophosphamide
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Effect of caloric restriction on Hprt lymphocyte mutation in aging rats
- DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
Similar Researchers
Based on overlapping research topics
Joseph G. Shaddock
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Becky Divine
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
C. J. Branscomb
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Michelle E. Bishop
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Robert H. Heflich
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Kamela Mitchell
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications