Match tier
Listed
Presence
Current · Arkansas
Last published
2023
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
P
Philip J. Breen
High Impact
Researcher
Also affiliated: Massachusetts College of Pharmacy and Health Sciences (1981–1988); Mexfam (2006); Altria (United States) (1989); Colorado State University (1987–1989)
Faculty Researcher
20 h-index
49 pubs
1,918 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Philip J. Breen's research focuses on the intersection of chemistry, pharmacology, and biology, with a particular emphasis on understanding molecular mechanisms and developing potential therapeutic agents. His work has explored the radioprotective effects of tocotrienols, investigating their dual roles as antioxidants and signaling molecules across multiple organ systems. Breen has also investigated compounds with antileukemic properties derived from plant-plant interactions.
His laboratory has conducted pharmacokinetic studies, including an analysis of morphine-6-O-sulfate in rat plasma and brain. Furthermore, Breen's research group has been involved in the development of novel tocotrienol analogues, such as tocoflexol, for potential use as radiomitigators. His scholarship is evidenced by a high-impact designation, with 49 publications and 1,880 citations, and an h-index of 20. He leads a research group and collaborates with several faculty members at the University of Arkansas for Medical Sciences, including Darin E. Jones, David E. Mery, Edward J. Selvik, and Nükhet Aykin‐Burns.
Metrics
- h-index: 20
- Publications: 49
- Citations: 1,918
Selected Publications
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)
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Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds (2022)
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A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain (2021)
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Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans) (2018)
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Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia (2016)
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Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059] (2016)
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Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone (2015)
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Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex (2015)
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Cyclodextrins in pharmaceutical formulations II: solubilization, binding constant, and complexation efficiency (2015)
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Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity (2015)
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The smoking habits of the family influence the uptake of e-cigarettes in US children (2014)
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Drug dissolution: significance of physicochemical properties and physiological conditions (2013)
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Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability (2013)
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Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity (2011)
Grants & Funding
As listed on this researcher's institutional profile.
- Developing Countermeasures for Acute Respiratory Distress Produced by Lunar Dust National Aeronautics & Space Administration via Arkansas Space Grant Consortium
Collaboration Network
Top Collaborators
Darin E. Jones
University of Arkansas for Medical Sciences
3 shared publications
In database
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
César M. Compadre
University of Arkansas for Medical Sciences
3 shared publications
In database
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Shivangi Shrimali
University of Arkansas at Little Rock
2 shared publications
In database
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Shraddha Thakkar
University of Arkansas for Medical Sciences (US)
2 shared publications
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Nükhet Aykin‐Burns
University of Arkansas for Medical Sciences
2 shared publications
In database
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Jai Shankar K. Yadlapalli
University of Arkansas for Medical Sciences
1 shared publication
In database
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Zaineb A.F. Albayati
University of Arkansas for Medical Sciences
1 shared publication
In database
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Maxim Dobretsov
University of Arkansas for Medical Sciences (US)
1 shared publication
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Narsimha Reddy Penthala
University of Arkansas for Medical Sciences
1 shared publication
In database
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Howard P. Hendrickson
University of Arkansas for Medical Sciences (US)
1 shared publication
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Peter A. Crooks
University of Arkansas for Medical Sciences
1 shared publication
In database
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
David E. Mery
University of Arkansas for Medical Sciences
1 shared publication
In database
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Amanda Compadre
University of Arkansas for Medical Sciences (US)
1 shared publication
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Paola E. Ordóñez
Universidad Yachay Tech (EC)
1 shared publication
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Edward J. Selvik
University of Arkansas for Medical Sciences
1 shared publication
In database
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
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