Brian D. Piccolo
Assistant Professor, Tenure Track
Also affiliated: Arkansas Children's Hospital (2018–2024); Agricultural Research Service (2015–2020); United States Department of Agriculture (2020–2022); University of California System (2011); Joint Center for Structural Genomics (2015); Western Human Nutrition Research Center (2015–2020); Arkansas Children's Nutrition Center (2016–2026); University of California, Davis (2010–2020)
Faculty Researcher
Peds Pediatrics, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Brian D. Piccolo's research focuses on the interplay between diet, the gut microbiome, and metabolic health, particularly in the context of obesity and liver disease. His work utilizes animal models, including mice, pigs, and rats, to investigate how dietary components and interventions influence microbial composition, bile acid metabolism, and disease progression. He has explored the effects of specific diets, such as blueberry, olive oil, and coconut oil, on vascular complications in diabetes and liver injury in models of non-alcoholic fatty liver disease (NAFLD).
Further investigations by Piccolo examine how dietary manipulations, like iron deficiency or varying fat compositions, impact gut health and enteric infections. His research also extends to human studies, analyzing how diet and exercise affect the gut microbiome and circulating metabolites in adults. He has published on the associations between maternal diet, body composition, and offspring gut microbiome in the first year of life, highlighting the importance of early life nutrition.
Piccolo holds an Assistant Professor position in the Department of Pediatrics at the University of Arkansas for Medical Sciences. His scholarship metrics include an h-index of 24 and over 1,700 citations across 90 publications. He leads a research group and collaborates with several colleagues at his institution, including Sree V. Chintapalli, Renny S. Lan, Sean H. Adams, and Lindsay Pack.
Metrics
- h-index: 24
- Publications: 93
- Citations: 1,878
Selected Publications
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Metabolic Functional Guilds Drive Fiber-Specific Xenometabolite Signatures From Human Gut Microbiota (2026)
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Integrating fingerprint prediction and physicochemical property filtering to annotate unknown metabolites from high-resolution MS/MS spectra (2026)
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Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures (2025)
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Beyond the Known Metabolome: Predictive Strategies for Dark Matter Discovery (2025)
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Fueling the fire: colonocyte metabolism and its effect on the colonic epithelia (2025)
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Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues (2024)
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Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice (2024)
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Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats (2024)
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Physiological response to fetal intravenous lipid emulsion (2024)
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Parental cardiorespiratory fitness influences early life energetics and metabolic health (2023)
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Exercise training modifies xenometabolites in gut and circulation of lean and obese adults (2023)
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Olive- and Coconut-Oil-Enriched Diets Decreased Secondary Bile Acids and Regulated Metabolic and Transcriptomic Markers of Brain Injury in the Frontal Cortexes of NAFLD Pigs (2022)
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Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD (2022)
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C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice (2022)
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Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis (2022)
Collaboration Network
Top Collaborators
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice
- Beyond the Known Metabolome: Predictive Strategies for Dark Matter Discovery
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI
- Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Fueling the fire: colonocyte metabolism and its effect on the colonic epithelia
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
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