Lin‐Xi Li

Federal Grant PI

Associate Professor

UAMS

Also affiliated: University of Minnesota (2010); National Cancer Center (2010); Institute of Immunology (2010); University of Minnesota Medical Center (2010–2011); L-3 Communications (United States) (2024); University of California, Davis (2012–2017)

Faculty Researcher

Microbiology & Immunology, College of Medicine

13 h-index 34 pubs 717 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group UAMS TRI Profile

OverviewAI-generated summary

Lin-Xi Li's research focuses on understanding the mechanisms of immune responses to infectious agents, particularly Chlamydia, and their impact on host health. Her work has explored the role of specific immune cells and signaling pathways in controlling Chlamydia dissemination and establishing protective immunity in the female reproductive tract. This includes investigating the differentiation and function of CD4 T cells, as well as the interplay between T cells and other immune components like antibodies.

Beyond Chlamydia, Li's research extends to other microbial infections, such as Mycobacterium tuberculosis, examining the role of immune cells like neutrophils and macrophages in conferring protection. She also investigates host immune responses in the context of disease models, including studies on hypertension, exploring the involvement of immune pathways and cellular interactions in its development and regulation. Her federally funded research, totaling over $558,000 from NIH/NIAID, supports her investigations into early protective immune responses and the mechanisms of memory CD4 T cell-mediated immunity against Chlamydia.

Li holds an h-index of 13 with 33 publications and 696 citations. She collaborates extensively with researchers at the University of Arkansas for Medical Sciences, including Miguel A. B. Mercado, J. Tucker Andrews, Lu Huang, and Rachel S. Palmer, with whom she has co-authored multiple publications.

Metrics

h-index: 13
Publications: 34
Citations: 717

Selected Publications

CXCR6 marks polyfunctional effector CD4 T cells required for anti- Chlamydia immunity in the female reproductive tract (2026)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025)

The Journal of Immunology DOI OpenAlex
The roles of TGFb signaling in CD4 T cell responses to Chlamydia infection in the female reproductive tract 9284 (2025)

The Journal of Immunology DOI OpenAlex
CXCR6+ polyfunctional CD4 T cells are essential for protective immunity against Chlamydia in the female reproductive tract (2024)

The Journal of Immunology DOI OpenAlex
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis (2024)

Mucosal Immunology 35 citations DOI OpenAlex
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia (2024)

PLoS Pathogens 4 citations DOI OpenAlex
P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension (2024)

Hypertension 8 citations DOI OpenAlex
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia (2023)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
Transcription factor Bhlhe40 plays a protective role during intravaginal Chlamydia muridarum infection in mice (2023)

The Journal of Immunology DOI OpenAlex
Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against Mycobacterium tuberculosis (2023)

The Journal of Immunology DOI OpenAlex
IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections (2022)

Infection and Immunity 4 citations DOI OpenAlex
IFNγ and antibody synergize to enhance protective immunity against Chlamydia dissemination and female reproductive tract reinfections (2022)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension (2022)

Circulation Research 42 citations DOI OpenAlex
Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021)

Journal of Molecular Endocrinology 8 citations DOI OpenAlex
Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract (2020)

Infection and Immunity 21 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 2 $558,240 total

NIH Contact PI May 2024 - Mar 2027

Exploring early protective immune responses to Chlamydia

National Institute of Allergy and Infectious Diseases $182,746 R21

NIH Contact PI May 2018 - Apr 2024

Mechanisms of memory CD4 T cell-mediated immune protection against Chlamydia

National Institute of Allergy and Infectious Diseases $375,494 R01

Grants & Funding

As listed on this researcher's institutional profile. Federal awards with verified records are shown above.

T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
Mechanisms of memory CD4 T cell-mediated immune protection against Chlamydia - Continuation NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator