Lin-Xi Li
Associate Professor
University of Arkansas for Medical Sciences
faculty
Microbiology & Immunology, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Lin-Xi Li's research investigates the complexities of the immune system, particularly focusing on T cell responses in the context of infectious diseases and chronic conditions. Her work has explored the mechanisms by which CD8+ T cells interact with other cellular components to influence hypertension, as detailed in her 2024 publication on P2X7-mediated activation. Additionally, her research delves into the role of specific immune cells, such as neutrophils, in creating environments permissive for pathogens like Mycobacterium tuberculosis, as highlighted in her 2024 publication.
Further contributions from Li's group examine protective immune responses to Chlamydia infection. This includes work on the differentiation of polyfunctional CD4 T cells, the influence of BHLHE40, and the regulatory roles of TGF-beta signaling in the female reproductive tract. Her research is supported by two NIH/NIAID grants totaling $558,240, which focus on the mechanisms of memory CD4 T cell-mediated immunity and early protective immune responses against Chlamydia.
Li leads a research group at the University of Arkansas for Medical Sciences and collaborates with several colleagues within the institution, including Miguel A. B. Mercado, J. Tucker Andrews, Lu Huang, and Rachel S. Palmer, with whom she has co-authored multiple publications.
Metrics
- h-index: 13
- Publications: 33
- Citations: 687
Selected Publications
- β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025) DOI
- The roles of TGFb signaling in CD4 T cell responses to Chlamydia infection in the female reproductive tract 9284 (2025) DOI
- CXCR6+ polyfunctional CD4 T cells are essential for protective immunity against Chlamydia in the female reproductive tract (2024) DOI
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis (2024) DOI
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia (2024) DOI
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against <i>Chlamydia</i> (2023) DOI
- Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice (2023) DOI
- Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against <i>Mycobacterium tuberculosis</i> (2023) DOI
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections (2022) DOI
- IFNγ and antibody synergize to enhance protective immunity against <i>Chlamydia</i> dissemination and female reproductive tract reinfections (2022) DOI
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021) DOI
Federal Grants 2 $558,240 total
Mechanisms of memory CD4 T cell-mediated immune protection against Chlamydia
Grants & Funding
- T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
- Mechanisms of memory CD4 T cell-mediated immune protection against Chlamydia - Continuation NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Exploring early protective immune responses to Chlamydia NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Exploring early protective immune responses to Chlamydia NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Exploring early protective immune responses to Chlamydia NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Exploring early protective immune responses to Chlamydia NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
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