Timothy C. Chambers

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

35 h-index 164 pubs 4,637 cited

Research Areas

Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Acute Lymphoblastic Leukemia research Breast Cancer Treatment Studies Glioma Diagnosis and Treatment Advanced Neural Network Applications Remote Sensing in Agriculture Pharmacological Effects and Toxicity Studies

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OverviewAI-generated summary

Timothy C. Chambers' research focuses on understanding and developing novel therapeutic strategies for various cancers, including glioblastoma, breast cancer, and acute lymphoblastic leukemia. His work has involved investigating the anti-cancer activity of natural compounds and their synthetic analogs, such as monensin and salinomycin. These studies often utilize advanced models, including organoids and 3D cell culture systems, to better recapitulate the tumor microenvironment and assess treatment efficacy against specific cell populations, like cancer stem cells.

Beyond oncology, Chambers' research portfolio extends to other areas. He has investigated the susceptibility of primary acute lymphoblastic leukemia cells to microtubule-targeting agents and explored the role of BH3 inhibitors and Bcl-2 dependence in these cells. Additionally, his work has touched upon the application of remote sensing technologies, specifically UAV multispectral imagery combined with deep learning algorithms, for mapping water stress in agricultural settings like vineyards.

Chambers leads a research group and has established significant collaborations with colleagues at the University of Arkansas for Medical Sciences, including Joshua M. Eichhorn, Alicja Urbaniak, Megan R. Reed, and Billie Heflin, with whom he has co-authored numerous publications. His scholarly contributions are reflected in a h-index of 35, over 4,600 citations, and 164 total publications, designating him as a highly cited researcher.

Metrics

h-index: 35
Publications: 164
Citations: 4,637

Selected Publications

Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG (2025) DOI
Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025) DOI
Data from Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine (2023) DOI
Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer (2022) DOI
Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer (2022) DOI
Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways (2022) DOI
Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle (2021) DOI
Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models (2021) DOI
Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs (2021) DOI
Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives (2021) DOI