Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
T
Timothy C. Chambers
High Impact
Role not yet determined Is this you? Add your title
Also affiliated: Rush University Medical Center (1994); Merck & Co., Inc., Rahway, NJ, USA (United States) (1988–1990); Emory University (1990–1994); Gdańsk University of Technology (2012); University of Arkansas Medical Center (2012); National Jewish Health (1986–1992); Winship Cancer Institute (1993); University of Colorado Anschutz (1990); University of Colorado Denver (1990)
35 h-index
161 pubs
4,732 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Timothy C. Chambers' research focuses on the molecular mechanisms underlying cellular responses to chemotherapeutic agents and the pathways involved in programmed cell death, or apoptosis. His work has investigated the role of specific signaling cascades, such as the JNK and ERK pathways, in mediating cellular fate following treatment with drugs like vinblastine and adriamycin. He has characterized the phosphorylation of key proteins, including Bcl-2, Bcl-XL, and P-glycoprotein, and identified the kinases responsible for these modifications, such as JNK and protein kinase C.
Chambers' research group has explored how these signaling events correlate with cellular outcomes, including mitotic arrest and cell survival. His publications detail the differential effects of microtubule inhibitors on mitogen-activated protein kinase (MAPK) pathways in tumor cells. He has also investigated the functional consequences of P-glycoprotein phosphorylation in multidrug-resistant cells, contributing to the understanding of drug resistance mechanisms.
With an h-index of 35, 167 total publications, and over 4,700 citations, Chambers is recognized as a highly cited researcher. He collaborates with colleagues at the University of Arkansas for Medical Sciences, including Joshua M. Eichhorn, Alicja Urbaniak, Megan R. Reed, and Billie Heflin, with whom he has co-authored multiple publications.
Metrics
- h-index: 35
- Publications: 161
- Citations: 4,732
Selected Publications
-
Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
-
Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG (2025)
-
Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
-
Data from Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine (2023)
-
Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer (2022)
-
Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer (2022)
-
Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways (2022)
-
Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle (2021)
-
Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models (2021)
-
Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs (2021)
Collaboration Network
Top Collaborators
Alicja Urbaniak
Cancer Institute (WIA)
25 shared publications
In database
- Biological activity of doubly modified salinomycin analogs – Evaluation in vitro and ex vivo
- Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents
- Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes
Showing 5 of 25 shared publications
Adam Huczyński
Adam Mickiewicz University in Poznań (PL)
20 shared publications
- Biological activity of doubly modified salinomycin analogs – Evaluation in vitro and ex vivo
- Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents
- Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes
Showing 5 of 20 shared publications
Magdalena Delgado
University of Arkansas for Medical Sciences (US)
15 shared publications
- Biological activity of doubly modified salinomycin analogs – Evaluation in vitro and ex vivo
- Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro
- Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes
- Contrasting effects of microtubule destabilizers versus stabilizers on induction of death in G1 phase of the cell cycle
- The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex�vivo study
Showing 5 of 15 shared publications
Rong Chu
University of Arkansas for Medical Sciences (US)
9 shared publications
- Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance
- Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration
- Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death
- Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine
- Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis
Showing 5 of 9 shared publications
Meenakshi Upreti
University of Arkansas for Medical Sciences
9 shared publications
In database
- Cyclin-Dependent Kinase 1-Mediated Bcl-x L /Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis
- Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance
- Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine
- Vinblastine-induced Apoptosis Is Mediated by Discrete Alterations in Subcellular Location, Oligomeric Structure, and Activation Status of Specific Bcl-2 Family Members
- Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis
Showing 5 of 9 shared publications
Greta Klejborowska
Adam Mickiewicz University in Poznań (PL)
9 shared publications
- Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells—in vitro and ex vivo study
- Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents
- Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives
Showing 5 of 9 shared publications
Christopher S. Lyle
University of Arkansas for Medical Sciences (US)
8 shared publications
- Inhibition of Cell Proliferation and Cell Cycle Progression by Specific Inhibition of Basal JNK Activity
- The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide
- Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction
- Distinct signaling pathways of microtubule inhibitors – vinblastine and Taxol induce JNK‐dependent cell death but through AP‐1‐dependent and AP‐1‐independent mechanisms, respectively
- Vinblastine-induced Apoptosis Is Mediated by Discrete Alterations in Subcellular Location, Oligomeric Structure, and Activation Status of Specific Bcl-2 Family Members
Showing 5 of 8 shared publications
Michał Antoszczak
Adam Mickiewicz University in Poznań (PL)
8 shared publications
- Biological activity of doubly modified salinomycin analogs – Evaluation in vitro and ex vivo
- Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro
- Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20‐oxo Analogues
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Double Modification of Polyether Ionophores: Synthesis and Biological Activity of Novel Salinomycin Derivatives
Showing 5 of 8 shared publications
Megan R. Reed
Cancer Institute (WIA)
8 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
Showing 5 of 8 shared publications
Joshua M. Eichhorn
University of Arkansas for Medical Sciences
7 shared publications
In database
- BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells
- Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival
- Cyclin-dependent Kinase-1 (Cdk1)/Cyclin B1 Dictates Cell Fate after Mitotic Arrest via Phosphoregulation of Antiapoptotic Bcl-2 Proteins
- Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death
- Purported Mcl-1 inhibitor marinopyrrole A fails to show selective cytotoxicity for Mcl-1-dependent cell lines
Showing 5 of 7 shared publications
Anisha Kothari
University of Arkansas for Medical Sciences (US)
7 shared publications
- BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells
- Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
- Cyclin B1 Overexpression Induces Cell Death Independent of Mitotic Arrest
- Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified
- Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation
Showing 5 of 7 shared publications
Alan J. Tackett
Cancer Institute (WIA)
7 shared publications
In database
- Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Showing 5 of 7 shared publications
Robert L. Eoff
Cancer Institute (WIA)
7 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
Showing 5 of 7 shared publications
Angus M. MacNicol
Cancer Institute (WIA)
7 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
Showing 5 of 7 shared publications
Elena Galitovskaya
University of Arkansas for Medical Sciences
6 shared publications
In database
- Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance
- Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine
- Synthesis and anticancer activity of sclerophytin-inspired hydroisobenzofurans
- ChemInform Abstract: Synthesis and Anticancer Activity of Sclerophytin‐Inspired Hydroisobenzofurans.
- Simplified analogs of sclerophytin A as potential anticancer agents
Showing 5 of 6 shared publications
Similar Researchers
Based on overlapping research topics
Hui‐Ming Chang
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
Receptor Mechanisms and Signaling
Pharmacological Effects and Toxicity Studies
Tsigereda Weldemichael
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
Receptor Mechanisms and Signaling
Pharmacological Effects and Toxicity Studies
Han M
University of Arkansas for Medical Sciences
Drug Transport and Resistance Mechanisms
Cancer Treatment and Pharmacology
Pharmacological Effects and Toxicity Studies
Jenat Rahman
University of Arkansas for Medical Sciences
Drug Transport and Resistance Mechanisms
Cancer Treatment and Pharmacology
Pharmacological Effects and Toxicity Studies
Noemi Garcia Garcia
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
Receptor Mechanisms and Signaling
Pharmacological Effects and Toxicity Studies
Azure L. Yarbrough
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
Receptor Mechanisms and Signaling
Pharmacological Effects and Toxicity Studies