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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
Melanie C MacNicol
High Impact
Associate Professor
Also affiliated: Arkansas Children's Hospital (2002); University of California, San Francisco (1995); University of Chicago (1995–2000); Stanford Medicine (1990–1992); Arkansas Children's Research Institute (2025); Stanford University (1990–1992)
Neurobiology & Developmental Science, College of Medicine
24 h-index
79 pubs
1,682 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Melanie C MacNicol's research investigates the molecular mechanisms underlying pituitary gland plasticity and function, with a particular focus on regulated mRNA translation and its role in cell communication. She has received significant federal funding for this work, including NIH grants totaling over $1.7 million.
Her recent publications explore critical physiological processes, such as the role of leptin in reproduction and its influence on gonadotrope function, and the regulation of gene expression by RNA-binding proteins like Musashi. MacNicol also studies age-related alterations in signaling pathways, including TGF-beta in muscle progenitors. Her work utilizes mouse models, such as mutant Profilin1 transgenic mice that recapitulate features of motor neuron disease.
MacNicol's scholarship metrics include an h-index of 24, with over 1,600 citations across 79 publications. She collaborates extensively with colleagues at the University of Arkansas for Medical Sciences, including Angus M. MacNicol, Gwen V. Childs, Angela K. Odle, and Alex Lagasse.
Metrics
- h-index: 24
- Publications: 79
- Citations: 1,682
Positions
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Associate Professor publications 2002–2026University of Arkansas for Medical Sciences Neurobiology & Developmental Science, College of Medicine Institutional directory
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University of Arkansas for Medical Sciences publications 2002–2026ORCID
Selected Publications
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ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation (2026)
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ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation (2026)
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025)
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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
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Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024)
Federal Grants 3 $1,783,459 total
NIH
Co-PI
Sep 2024 - May 2029
NIH
Co-PI
Jul 2021 - Jun 2026
NIH
Co-PI
Sep 2018 - Jun 2025
Control of pituitary cell plasticity through regulated mRNA translation
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Center for Translational Neuroscience NIH Co-Investigator
- Maternal gene regulation in early vertebrate development NIH Co-Investigator
- TEST OF THE RECEPTOR DOMAIN OF CAM KINASE IN VIVO NIH/NIGMS Principal Investigator
- Tropic Roles for Leptin in the Maturation of Somatotropes NIH Co-Principal Investigator
- Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes NIH Co-Investigator
Collaboration Network
Top Collaborators
Angus M. MacNicol
University of Arkansas for Medical Sciences
56 shared publications
In database
- The Importance of Leptin to Reproduction
- Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation.
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Enforcing temporal control of maternal mRNA translation during oocyte cell‐cycle progression
- Function and regulation of the mammalian Musashi mRNA translational regulator
Showing 5 of 56 shared publications
Gwen V. Childs
University of Arkansas for Medical Sciences
40 shared publications
In database
- The Importance of Leptin to Reproduction
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- Molecular Mechanisms of Pituitary Cell Plasticity
- Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2
Showing 5 of 40 shared publications
Angela K. Odle
University of Arkansas for Medical Sciences
37 shared publications
In database
- The Importance of Leptin to Reproduction
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- The use of three-dimensional printing to produce in vitro slice chambers
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
Showing 5 of 37 shared publications
Anessa Haney
University of Arkansas for Medical Sciences
25 shared publications
In database
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
Showing 5 of 25 shared publications
Tiffany K. Miles
Arkansas Children's Hospital
18 shared publications
In database
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- Sex differences in somatotrope response to fasting: biphasic responses in male mice
Showing 5 of 18 shared publications
Alex Lagasse
University of Arkansas for Medical Sciences
18 shared publications
In database
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Showing 5 of 18 shared publications
Linda Hardy
University of Arkansas for Medical Sciences
15 shared publications
In database
- Enforcing temporal control of maternal mRNA translation during oocyte cell‐cycle progression
- Ringo/Cyclin-dependent Kinase and Mitogen-activated Protein Kinase Signaling Pathways Regulate the Activity of the Cell Fate Determinant Musashi to Promote Cell Cycle Re-entry in Xenopus Oocytes
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- Neural stem and progenitor cell fate transition requires regulation of Musashi1 function
- Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2
Showing 5 of 15 shared publications
Melody Allensworth‐James
University of Arkansas for Medical Sciences
12 shared publications
In database
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
Showing 5 of 12 shared publications
Stephanie D. Byrum
Arkansas Children's Hospital
12 shared publications
In database
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
Showing 5 of 12 shared publications
Ana Rita Silva Moreira
University of Arkansas for Medical Sciences (US)
11 shared publications
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Sex differences in somatotrope response to fasting: biphasic responses in male mice
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Showing 5 of 11 shared publications
Jewel Banik
Stanford University
10 shared publications
In database
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
Showing 5 of 10 shared publications
Ashley Herdman
University of Arkansas for Medical Sciences
9 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 9 shared publications
Juchan Lim
Symbiosis International University
7 shared publications
In database
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- SAT-284 Musashi Exerts Translational Control Within Anterior Pituitary Cells of the POU1F1 Lineage
Showing 5 of 7 shared publications
Ulrich Boehm
Saarland University (DE)
7 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- SAT-292 Musashi: A Novel Regulator of the Gonadotrope Transcriptome
- Musashi as a Regulator of the Follicle-Stimulating Hormone in the Gonadotropes
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
Showing 5 of 7 shared publications
Noor Akhter
University of Arkansas for Medical Sciences
6 shared publications
In database
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
- Leptin: A Metabolic Signal for the Differentiation of Pituitary Cells
- THU043 Single-cell Transcriptomics Show Sex-specific Responses To A High Fat Diet, Under Thermoneutral Conditions, Pointing To Reduced Pituitary Plasticity
Showing 5 of 6 shared publications
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