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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-09
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Kevin A. Murach
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
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Also affiliated: James Madison University (2012–2016); University of Kentucky (2015–2026); University of Pittsburgh (2015); Ball State University (2012–2018); Albert B. Chandler Hospital (2015–2016); Translational Research Institute for Metabolism and Diabetes (2015); San Francisco State University (2015); University of Missouri (2026)
37 h-index
189 pubs
4,214 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Kevin A. Murach's research focuses on skeletal muscle physiology, particularly in the context of adaptation, aging, and hypertrophy. He has received significant federal funding from the NIH/National Institute on Aging for studies investigating the role of myonuclear epigenetics in skeletal muscle mass regulation and the mediators of muscle rejuvenation with aging. His work has explored the cellular mechanisms underlying muscle growth and the impact of exercise on muscle adaptation across different life stages.
Murach's publications address topics such as the differential requirement for satellite cells in muscle hypertrophy, the effects of concurrent exercise training, and the relationship between myonuclear density and muscle adaptation during training and detraining. He has also investigated how late-life exercise can mitigate epigenetic aging in skeletal muscle. His scholarly contributions are reflected in a high h-index of 36 and over 4,000 citations across more than 160 publications. He actively collaborates with researchers at the University of Arkansas at Fayetteville, including Nicholas P. Greene, Francielly Morena da Silva, Pieter J. Koopmans, and Sabin Khadgi.
Metrics
- h-index: 37
- Publications: 189
- Citations: 4,214
Selected Publications
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ACL injury reprograms quadriceps myonuclear epigenetic and transcriptional signatures in mice (2026)
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Myonuclear Dynamics After Skeletal Muscle Surgical Injury (2026)
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Differential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a preclinical model of colorectal cancer by biological sex (2026)
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Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations (2026)
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Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia (2026)
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Combined senolytics induce varied phenotypic and functional responses on senescent phenotypes of mesenchymal stromal cell populations (2026)
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Myonuclear Dynamics After Skeletal Muscle Surgical Injury (2026)
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Targeting collagen cross-linking to support aged muscle hypertrophy (2026)
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Resident myonuclear adaptations to mechanical overload in single muscle fibers of HSA-GFP mice (2026)
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Progressive Weighted Wheel Running Enhances Neuromuscular Junction Innervation and Muscle Power in Aged Mice (2026)
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TRAIL: A potential new biomarker for muscle health in anorexia nervosa (2026)
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Assessing the role of cellular senescence on skeletal muscle fiber type-specific atrophy in older adults (2026)
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Identifying quiescent satellite cells: a scoping review of transcriptomic markers and limitations (2026)
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Ribosome dynamics during skeletal muscle repair and regeneration in mice and humans (2026)
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Myonuclear Dynamics After Skeletal Muscle Surgical Resection Injury (2026)Journal of the Arkansas Academy of Science OpenAlex
Federal Grants 3 $903,946 total
NIH
Contact PI
Jun 2025 - Jun 2026
NIH
Contact PI
Aug 2023 - Apr 2028
NIH
Contact PI
Aug 2019 - Jul 2025
Myonuclear Epigenetics of Skeletal Muscle Mass Regulation with Age
Collaboration Network
Top Collaborators
Nicholas P. Greene
University of Arkansas at Fayetteville
27 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
Showing 5 of 27 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
24 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
Showing 5 of 24 shared publications
Yuan Wen
University of Kentucky (US)
20 shared publications
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
Showing 5 of 20 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
20 shared publications
In database
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice
Showing 5 of 20 shared publications
Ronald G. Jones
University of Arkansas at Fayetteville
19 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
- Exercise-Induced MYC as an Epigenetic Reprogramming Factor That Combats Skeletal Muscle Aging
Showing 5 of 19 shared publications
Tyrone A. Washington
University of Arkansas at Fayetteville
17 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
Showing 5 of 17 shared publications
John J. McCarthy
University of Kentucky (US)
16 shared publications
- Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- The myonuclear domain in adult skeletal muscle fibres: past, present and future
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
Showing 5 of 16 shared publications
Pieter J. Koopmans
University of Arkansas at Fayetteville
16 shared publications
In database
- The roles of miRNAs in adult skeletal muscle satellite cells
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Going nuclear: Molecular adaptations to exercise mediated by myonuclei
- At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic ( BI01 ) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle
- MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16
Showing 5 of 16 shared publications
Ferdinand von Walden
Hong Kong Science and Technology Parks Corporation (HK)
15 shared publications
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
Showing 5 of 15 shared publications
Eleanor R. Schrems
University of Arkansas at Fayetteville
15 shared publications
In database
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice
Showing 5 of 15 shared publications
Cory M. Dungan
Baylor University (US)
13 shared publications
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
- Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise
Showing 5 of 13 shared publications
Christopher S. Fry
University of Kentucky (US)
13 shared publications
- Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
Showing 5 of 13 shared publications
Stavroula Tsitkanou
Beth Israel Deaconess Medical Center
13 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice
- Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice
Showing 5 of 13 shared publications
Megan E. Rosa‐Caldwell
Beth Israel Deaconess Medical Center
13 shared publications
In database
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from Males
- Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa
- Divergent alterations in the skeletal muscle and serum proteome in a rodent model of anorexia nervosa and weight recovery
Showing 5 of 13 shared publications
Ahmed Ismaeel
Auburn University (US)
11 shared publications
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
- The roles of miRNAs in adult skeletal muscle satellite cells
- Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus
- Skeletal muscle hypertrophy: cell growth is cell growth
- microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism
Showing 5 of 11 shared publications
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