T
Toby L. Chambers Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Post-Doctoral Research Scholar
postdoc
12 h-index
42 pubs
869 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Toby L. Chambers investigates the molecular and epigenomic signatures associated with exercise training, focusing on skeletal muscle adaptations. Their research explores the temporal dynamics of multi-omic responses to endurance exercise across different tissues in humans and animal models. Chambers has published work examining single muscle fiber contractile characteristics in relation to lifelong endurance exercise and the impact of exercise on the methylome and proteome in aging skeletal muscle. Recent studies also investigate the role of MYC in muscle growth following exercise and the effects of senolytic administration on DNA methylation and skeletal muscle health in aged mice. Chambers' work contributes to understanding how exercise influences biological processes at the molecular level, with implications for skeletal muscle health and aging.
Metrics
- h-index: 12
- Publications: 42
- Citations: 869
Selected Publications
-
Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa (2025)
-
Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice (2025)
-
Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females (2025)
-
Consensus Statements—Optimizing Performance of the Elite Athlete (2025)
-
Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice (2025)
-
A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review (2025)
-
A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity (2025)
-
The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth (2024)
-
Methylome–proteome integration after late‐life voluntary exercise training reveals regulation and target information for improved skeletal muscle health (2024)
Collaboration Network
Top Collaborators
Scott Trappe
Ball State University (US)
18 shared publications
- Single muscle fibre contractile characteristics with lifelong endurance exercise
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content
- Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise
- Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE<sub>2</sub>/COX pathway activity
- Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise
Showing 5 of 18 shared publications
Todd A. Trappe
Ball State University (US)
18 shared publications
- Single muscle fibre contractile characteristics with lifelong endurance exercise
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content
- Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise
- Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE<sub>2</sub>/COX pathway activity
- Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise
Showing 5 of 18 shared publications
Kiril Minchev
Ball State University (US)
15 shared publications
- Single muscle fibre contractile characteristics with lifelong endurance exercise
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content
- Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise
- Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE<sub>2</sub>/COX pathway activity
- Exercise microdosing for skeletal muscle health applications to spaceflight
Showing 5 of 15 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
9 shared publications
In database
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Methylome–proteome integration after late‐life voluntary exercise training reveals regulation and target information for improved skeletal muscle health
- A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review
- At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic ( <scp>BI01</scp> ) Administration on <scp>DNA</scp> Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle
- A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity
Showing 5 of 9 shared publications
Kevin J. Gries
8 shared publications
- Single muscle fibre contractile characteristics with lifelong endurance exercise
- Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise
- Exercise microdosing for skeletal muscle health applications to spaceflight
- Multitissue responses to exercise: a MoTrPAC feasibility study
- JAPPL-00491-2023 Supplemental Material
Showing 5 of 8 shared publications
Ulrika Raue
Ball State University (US)
8 shared publications
- Single muscle fibre contractile characteristics with lifelong endurance exercise
- Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise
- Exercise microdosing for skeletal muscle health applications to spaceflight
- Multitissue responses to exercise: a MoTrPAC feasibility study
- JAPPL-00491-2023 Supplemental Material
Showing 5 of 8 shared publications
Cristhian F. Montenegro
Ball State University (US)
6 shared publications
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content
- Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE<sub>2</sub>/COX pathway activity
- Fast and slow myofiber nuclei, satellite cells, and size distribution with lifelong endurance exercise in men and women
- Multitissue responses to exercise: a MoTrPAC feasibility study
- <strong>Table S1.</strong>JAPPL-00210-2023 Table S1
Showing 5 of 6 shared publications
Dillon Kuszmaul
Ball State University (US)
6 shared publications
- Fast and slow myofiber nuclei, satellite cells, and size distribution with lifelong endurance exercise in men and women
- Multitissue responses to exercise: a MoTrPAC feasibility study
- Effect of adipose biopsy technique on adipocyte size and integrity
- Myocellular differences between the soleus and vastus lateralis
- <strong>Table S1.</strong>JAPPL-00210-2023 Table S1
Showing 5 of 6 shared publications
Masatoshi Naruse
5 shared publications
- Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE<sub>2</sub>/COX pathway activity
- Multitissue responses to exercise: a MoTrPAC feasibility study
- Effect of adipose biopsy technique on adipocyte size and integrity
- <strong>Table S1.</strong>JAPPL-00210-2023 Table S1
- <strong>Table S1.</strong>
William A. Fountain
5 shared publications
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content
- Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE<sub>2</sub>/COX pathway activity
- Multitissue responses to exercise: a MoTrPAC feasibility study
- <strong>Table S1.</strong>JAPPL-00210-2023 Table S1
- <strong>Table S1.</strong>
Andrew M. Stroh
5 shared publications
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content
- Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE<sub>2</sub>/COX pathway activity
- Multitissue responses to exercise: a MoTrPAC feasibility study
- <strong>Table S1.</strong>JAPPL-00210-2023 Table S1
- <strong>Table S1.</strong>
Colleen E. Lynch
5 shared publications
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content
- Influence of low‐dose aspirin, resistance exercise, and sex on human skeletal muscle PGE<sub>2</sub>/COX pathway activity
- Multitissue responses to exercise: a MoTrPAC feasibility study
- Adipose biopsy techniques for studies in human exercise physiology
- R-00266-2023 Supplemental Tables 1-4 12.22.23.pdf
Gwénaëlle Begue
5 shared publications
- Single muscle fibre contractile characteristics with lifelong endurance exercise
- Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise
- Exercise microdosing for skeletal muscle health applications to spaceflight
- JAPPL-00491-2023 Supplemental Material
- Supplemental Tables and Excel files for lifelong exercise transcritpome responses to exercise in slow and fast muscle fibers.
Anna Brandt
Ball State University (US)
5 shared publications
- Effect of adipose biopsy technique on adipocyte size and integrity
- <strong>Table S1.</strong>JAPPL-00210-2023 Table S1
- R-00266-2023 Supplemental Tables 1-4 12.22.23.pdf
- <strong>Table S1.</strong>
- Effect of Adipose Biopsy Technique on Inflammatory Markers in Adipose Tissue
Elena Zaslavsky
Icahn School of Medicine at Mount Sinai (US)
5 shared publications
- Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures
- Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise
- Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise
- Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise
- Supplemental Tables and Excel files for lifelong exercise transcritpome responses to exercise in slow and fast muscle fibers.
Similar Researchers
Based on overlapping research topics
Lois Geren
University of Arkansas at Fayetteville
Metabolism and Genetic Disorders
Genomics and Phylogenetic Studies
Protein Structure and Dynamics
Clayre Parson
University of Arkansas at Fayetteville
Metabolism and Genetic Disorders
Genomics and Phylogenetic Studies
Protein Structure and Dynamics
Pieter J Koopmans
University of Arkansas at Fayetteville
Epigenetics and DNA Methylation
Muscle Physiology and Disorders
Exercise and Physiological Responses
Sabin Khadgi
University of Arkansas at Fayetteville
Muscle Physiology and Disorders
Exercise and Physiological Responses
Metabolism and Genetic Disorders
Landen W. Saling
University of Arkansas at Fayetteville
Muscle Physiology and Disorders
Metabolism and Genetic Disorders
Genomics and Phylogenetic Studies
Kevin Hinkle
University of Arkansas for Medical Sciences
Muscle Physiology and Disorders
Exercise and Physiological Responses
Metabolism and Genetic Disorders