Seongok Lee

Post Doctoral Fellow

University of Arkansas for Medical Sciences

postdoc

Radiation Oncology, College of Medicine

3 h-index 13 pubs 123 cited

Research Areas

DNA Repair Mechanisms Mitochondrial Function and Pathology Organ Transplantation Techniques and Outcomes Ubiquitin and proteasome pathways Ischemia and Reperfusion Cancer-related molecular mechanisms research Protein Structure and Dynamics Kidney Disease and Treatment

Links

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OverviewAI-generated summary

Seongok Lee's research focuses on fundamental biological processes, particularly those related to DNA damage and repair, and kidney injury in the context of transplantation and ischemia-reperfusion. Lee has investigated the role of proteins such as ZMYM2 in regulating DNA double-strand break repair pathways, specifically its interaction with 53BP1 and BRCA1 loading. Further work has explored the impact of histone modifications on DNA repair mechanisms and the fine-tuning of histone ubiquitination by proteins like UBA80 and UBA52.

Additionally, Lee's research extends to organ transplantation, examining kidney graft injury following cold storage and transplantation. This includes studies on the mechanism of impaired protein homeostasis in kidney grafts and the role of complement 5 in mitochondria during ischemia-reperfusion injury in rats. Lee has also investigated the mitigation of post-ischemia and reperfusion kidney injury in complement 5 knockout rats.

Metrics

h-index: 3
Publications: 13
Citations: 123

Selected Publications

Complement 5's Role in Mitochondria During Kidney Ischemia-Reperfusion Injury in Rats (2025) DOI
Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat (2025) DOI
Mechanism of Impaired Protein Homeostasis in Kidney Grafts Following Cold Storage and Transplantation (Abstract ID: 162640) (2025) DOI
Ischemia and Reperfusion (IRI)-Induced Kidney Injury Is Attenuated by Complement 5 Gene Deletion (Abstract ID: 161749) (2025) DOI
Mechanism of Impaired Protein Homeostasis in Kidney Grafts following Cold Storage and Transplant (2024) DOI
Evolved histone tail regulates 53BP1 recruitment at damaged chromatin (2024) DOI
Normal Proteasome Function Is Needed to Prevent Kidney Graft Injury during Cold Storage Followed by Transplantation (2024) DOI
Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function (2024) DOI
Ischemia-Reperfusion-Mediated Kidney Injury Is Attenuated in a New Complement 5 Knockout Model (2023) DOI
Cold Storage-Mediated p38MAPK Activation: A Potential Contributor of Proteasome Dysfunction and Kidney Damage After Transplantation (2023) DOI
Mechanism of Cold Storage-Mediated Regulation of Heat Shock Proteins in Renal Grafts After Transplantation (2023) DOI
UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair (2023) DOI
ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination (2022) DOI