Ramani Atluri

Researcher

University of Arkansas for Medical Sciences

unknown

4 h-index 4 pubs 69 cited

Research Areas

Alzheimer's disease research and treatments Neuroscience and Neuropharmacology Research Protein Structure and Dynamics Dementia and Cognitive Impairment Research Neurological disorders and treatments Metabolism and Genetic Disorders Pharmacological Effects and Toxicity Studies Health and Medical Research Impacts

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OverviewAI-generated summary

Ramani Atluri's research investigates mechanisms of neurodegeneration, focusing on the role of protein aggregation and cellular processes like autophagy. Recent publications explore how misfolded proteins can entrap RNA and DNA, and how slowing translational elongation might mitigate this. Atluri has also examined the potential of small molecules, such as thiadiazolidinone analogs, to inhibit aggregation-mediated pathology in models of diverse neurodegenerative diseases, including Alzheimer's disease. Further work has highlighted the impact of ezetimibe in lowering the risk of Alzheimer's and related dementias, potentially by inhibiting specific protein interactions involved in aggregation. Atluri collaborates with researchers at the University of Arkansas for Medical Sciences, including Robert J. Shmookler Reis, Srinivas Ayyadevara, and Meenakshisundaram Balasubramaniam, with whom they have co-authored multiple publications. Atluri's scholarly metrics include an h-index of 4, with 4 total publications and 69 citations.

Metrics

  • h-index: 4
  • Publications: 4
  • Citations: 69

Selected Publications

  • Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024) DOI
  • Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024) DOI
  • Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023) DOI
  • “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation (2021) DOI

Collaborators

Researchers in the database who share publications

Robert J. Shmookler Reis University of Arkansas for Medical Sciences 4 shared publications Srinivas Ayyadevara University of Arkansas for Medical Sciences 4 shared publications Meenakshisundaram Balasubramaniam University of Arkansas for Medical Sciences 4 shared publications Akshatha Ganne University of Arkansas for Medical Sciences 3 shared publications Steven W. Barger University of Arkansas for Medical Sciences 2 shared publications Nirjal Mainali University of Arkansas for Medical Sciences 2 shared publications Narsimha Reddy Penthala University of Arkansas for Medical Sciences 1 shared publication Sue Griffin University of Arkansas for Medical Sciences 1 shared publication

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