Nirjal Mainali

Researcher

UAMS primary UA Little Rock

Also affiliated: Institute on Aging (2023–2025)

Faculty Researcher

8 h-index 14 pubs 191 cited

Research Areas

Biomedical Subjects

Links

ORCID

OverviewAI-generated summary

Nirjal Mainali investigates the molecular mechanisms underlying aging and age-associated neurodegenerative diseases, with a particular focus on the roles of mitochondria and endoplasmic reticulum stress. His research explores how cellular dysfunction contributes to conditions such as Alzheimer's disease and myocardial infarction. Mainali's work has identified potential therapeutic strategies, including the inhibition of protein aggregation and the targeting of specific protein interactions, such as the 14-3-3G::Hexokinase interaction. He has also developed computational tools, like the leave-one-out-analysis (LOOA) web-based tool, to aid in the analysis of proteomic data related to aggregate crosslinking. Mainali has a significant publication record, with a recent emphasis on Alzheimer's disease and related dementias, and collaborates extensively with researchers at the University of Arkansas for Medical Sciences, including Robert J. Shmookler Reis and Srinivas Ayyadevara.

Metrics

h-index: 8
Publications: 14
Citations: 191

Selected Publications

Development of an AI-Enhanced Workflow for Automated Quality Classification of Biomedical Fluorescence (2026)

SSRN Electronic Journal DOI OpenAlex
Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology (2025)

Basic Research in Cardiology DOI OpenAlex
Mitochondria in aging and age-associated diseases (2025)

Mitochondrion 26 citations DOI OpenAlex
Strong reduction of cryoprotectant toxicity by stress response induction (2024)

Cryobiology DOI OpenAlex
Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024)

12 citations DOI OpenAlex
Model biological systems demonstrate the inducibility of pathways that strongly reduce cryoprotectant toxicity (2024)

Cryobiology 5 citations DOI OpenAlex
Leave-one-out-analysis (LOOA): web-based tool to predict influential proteins and interactions in aggregate-crosslinking proteomic data (2024)

Bioinformation 7 citations DOI OpenAlex
Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets (2023)

iScience 10 citations DOI OpenAlex
Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain (2023)

Molecular and Cellular Biochemistry 16 citations DOI OpenAlex
Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023)

Pharmaceuticals 14 citations DOI OpenAlex
Protein homeostasis in the aged and diseased heart (2023)

The Journal of Cardiovascular Aging 8 citations DOI OpenAlex
Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases (2022)

International Journal of Molecular Sciences 10 citations DOI OpenAlex
Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs (2020)

Scientific Reports 45 citations DOI OpenAlex
Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation (2020)

Molecules 36 citations DOI OpenAlex