Match tier
Likely match
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
L
Li Pang
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Role not yet determined Is this you? Add your title
Also affiliated: United States Food and Drug Administration (2012–2025); University of Utah (1992); University of Arkansas Medical Center (2008); Montreal Heart Institute (2001–2006); Hôpital Maisonneuve-Rosemont (2000); Centre Hospitalier de l’Université de Montréal (2001); Hôtel-Dieu de Montréal (2001); The University of Texas Medical Branch at Galveston (2006); Université de Montréal (2000–2006)
17 h-index
47 pubs
2,078 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Li Pang's research focuses on the application of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for evaluating drug-induced cardiotoxicity. This work involves developing and validating nonclinical regulatory studies that utilize human iPSC-CMs to predict potential cardiac safety issues associated with new drug candidates. Pang's publications detail methodologies for optimizing compound preparation and serum conditions for delayed repolarization evaluations using these iPSC-CMs.
Pang has also investigated the use of iPSC-CMs in proof-of-concept studies to predict cardiotoxicity from specific oncology drugs, such as doxorubicin. Beyond cardiotoxicity, the researcher's work extends to other areas of toxicology, including the assessment of mitochondrial function impairment in human hepatocytes by specific compounds, and the development of novel delivery systems for mRNA-based therapeutics, such as cationic polymeric micellar structures designed for enhanced intramuscular transfection.
With an h-index of 22 and over 2,500 citations across 84 publications, Pang is recognized as a highly cited researcher. Key collaborators at the National Center for Toxicological Research include William B. Mattes, Katy S Papineau, Lijun Ren, and Prathyusha Bagam. Pang leads a research group and has recently been active with publications in 2024 and 2025.
Metrics
- h-index: 17
- Publications: 47
- Citations: 2,078
Selected Publications
-
Validating and Using Cardiac NAMs for Toxicity Screening and Drug Development (2025)
-
Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025)
-
Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024)
-
New Alternative Methods in Drug Safety Assessment (2023)
-
Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment (2022)
-
Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs (2022)
-
Improving cardiotoxicity prediction in cancer treatment: integration of conventional circulating biomarkers and novel exploratory tools (2020)
-
Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations (2020)
-
Toxicity testing in the era of induced pluripotent stem cells: A perspective regarding the use of patient-specific induced pluripotent stem cell–derived cardiomyocytes for cardiac safety evaluation (2020)
-
Effects of Electrical Stimulation on hiPSC-CM Responses to Classic Ion Channel Blockers (2020)
-
Bridging the gap between data from human iPSC-derived cardiomyocytes and CiPA simulation (2019)
-
Sex differences in repolarization reserve, a possible mechanism for sex-related differences in drug-induced QT prolongation and torsades de pointes (2019)
-
Workshop Report (2019)
-
MS07.2 Sex Difference of Repolarization Reserve On Drug-induced QT Prolongation and Arrhythmias (2018)
-
Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs (2018)
Collaboration Network
Top Collaborators
Beverly Lyn‐Cook
National Center for Toxicological Research
14 shared publications
In database
- Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
- Workshop Report
- Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers
- Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs
- ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance?
Showing 5 of 14 shared publications
Xi Yang
RTI International (US)
10 shared publications
- Workshop Report
- Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment
- Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers
- MicroRNA-mediated maturation of human pluripotent stem cell-derived cardiomyocytes: Towards a better model for cardiotoxicity?
- Improving cardiotoxicity prediction in cancer treatment: integration of conventional circulating biomarkers and novel exploratory tools
Showing 5 of 10 shared publications
Beverly Word
National Center for Toxicological Research
8 shared publications
In database
- Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers
- ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance?
- Abstract 4428: Metformin effects on ABCB1 expression and proliferation in pancreatic cancer cell lines with different ABCB1 genotypes/haplotypes
- Abstract 759: ATP-binding cassette (ABC) genes genotype and expression: A potential association with pancreatic cancer development and chemoresistance
- Abstract A44: Individual variation in hENT expression in normal and malignant pancreatic tissues: The role of dietary agents in enhancing efficacy in gemcitabine treatment.
Showing 5 of 8 shared publications
Norman Stockbridge
Center for Drug Evaluation and Research (US)
8 shared publications
- International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
- Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
- Workshop Report
- Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers
- Effects of Electrical Stimulation on hiPSC-CM Responses to Classic Ion Channel Blockers
Showing 5 of 8 shared publications
David G. Strauss
United States Food and Drug Administration (US)
5 shared publications
- International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
- Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
- Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment
- Effects of Electrical Stimulation on hiPSC-CM Responses to Classic Ion Channel Blockers
- Comprehensive assessment of multiple induced pluripotent stem cell-derived cardiomyocyte cell lines with microelectrode arrays and voltage sensitive dyes
Chengzhong Cai
National Center for Toxicological Research
5 shared publications
In database
- Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs
- Improving cardiotoxicity prediction in cancer treatment: integration of conventional circulating biomarkers and novel exploratory tools
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- MS07.2 Sex Difference of Repolarization Reserve On Drug-induced QT Prolongation and Arrhythmias
- Sex differences in repolarization reserve, a possible mechanism for sex-related differences in drug-induced QT prolongation and torsades de pointes
George Hammons
National Center for Toxicological Research
4 shared publications
In database
- ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance?
- Abstract 4428: Metformin effects on ABCB1 expression and proliferation in pancreatic cancer cell lines with different ABCB1 genotypes/haplotypes
- Abstract 759: ATP-binding cassette (ABC) genes genotype and expression: A potential association with pancreatic cancer development and chemoresistance
- Abstract 5376: Expression of histone deacetylases (HDACs) 1, 2, 3 and 7 in pancreatic cancer cell lines: The role of indole-3-carbinol.
Ksenia Blinova
United States Food and Drug Administration (US)
4 shared publications
- International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
- Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
- Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations
- Comprehensive assessment of multiple induced pluripotent stem cell-derived cardiomyocyte cell lines with microelectrode arrays and voltage sensitive dyes
Godfrey L. Smith
University of Glasgow (GB)
4 shared publications
- International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
- Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
- Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations
- Comprehensive assessment of multiple induced pluripotent stem cell-derived cardiomyocyte cell lines with microelectrode arrays and voltage sensitive dyes
Mathew Brock
4 shared publications
- International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
- Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
- Workshop Report
- Comprehensive assessment of multiple induced pluripotent stem cell-derived cardiomyocyte cell lines with microelectrode arrays and voltage sensitive dyes
Wei Feng
National Center for Toxicological Research (US)
4 shared publications
- Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs
- Effects of Electrical Stimulation on hiPSC-CM Responses to Classic Ion Channel Blockers
- Improving cardiotoxicity prediction in cancer treatment: integration of conventional circulating biomarkers and novel exploratory tools
- Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs
Hong‐Gang Wang
National Center for Toxicological Research (US)
3 shared publications
- ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance?
- Abstract A44: Individual variation in hENT expression in normal and malignant pancreatic tissues: The role of dietary agents in enhancing efficacy in gemcitabine treatment.
- Abstract B15: Expression of ABC transporters in human pancreatic cancer cell lines and correlation with gemcitabine sensitivity.
Daniel Millard
Axion Biosystems (United States) (US)
3 shared publications
- International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
- Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
- Comprehensive assessment of multiple induced pluripotent stem cell-derived cardiomyocyte cell lines with microelectrode arrays and voltage sensitive dyes
Jianhua Huo
National Center for Toxicological Research (US)
3 shared publications
- Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers
- Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs
- Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes From Two Major Suppliers
Neil Daily
Invivo Sciences (United States) (US)
3 shared publications
- Computational Model for Simulating Drug-Induced Arrhythmia Sensitivity of Human iPSC-derived Cardiomyocytes
- Simulating Drug-Induced Arrhythmia Sensitivity using an Expression-Based Theoretical Model of Human IPSC-Derived Cardiomyocytes
- Bridging the gap between data from human iPSC-derived cardiomyocytes and CiPA simulation
Similar Researchers
Based on overlapping research topics
J.C. Hsu
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Cardiovascular Function and Risk Factors
Mitochondrial Function and Pathology
Carrie L. Moland
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Cardiovascular Function and Risk Factors
Disease Models, Animal
Vikrant Vijay
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Cardiovascular Function and Risk Factors
Disease Models, Animal
John Lowery
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Cardiovascular Function and Risk Factors
Disease Models, Animal
R W Petty
University of Arkansas for Medical Sciences
Disease Models, Animal
Molecular Biology Techniques and Applications
Drug Delivery Systems
Qiang Shi
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Disease Models, Animal
Mitochondrial Function and Pathology