April C.L. Bostian
Researcher
Also affiliated: Arkansas Biosciences Institute (2017)
Unknown Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
April C.L. Bostian investigates the molecular mechanisms underlying cancer, with a recent focus on glioma cells. Her work examines the role of tryptophan 2,3-dioxygenase (TDO) and its impact on DNA damage tolerance and repair pathways within these cells. Bostian's research has shown that inhibiting TDO can impair these critical cellular processes in glioma, suggesting potential therapeutic avenues. Her scholarship metrics include an h-index of 4, with a total of 8 publications and 77 citations. She has collaborated with researchers at the University of Arkansas for Medical Sciences, including Amit Ketkar, Robert L. Eoff, Maroof K. Zafar, and Alan J. Tackett, on shared publications.
Metrics
- h-index: 4
- Publications: 8
- Citations: 79
Selected Publications
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2020)
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Inhibition of Kynurenine Signaling Decreases Glioblastoma Multiforme Genomic Instability and Sensitizes Cells to Chemotherapeutic Treatment (2017)
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Aberrant Kynurenine Signaling Modulates DNA Replication Stress Factors and Promotes Genomic Instability in Gliomas (2016)
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Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells (2016)
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Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells (2015)
Collaboration Network
Top Collaborators
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
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