A
Amit Ketkar
Instructor
faculty
Biochemistry & Molecular Biology, College of Medicine
19 h-index
42 pubs
837 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Amit Ketkar's research focuses on DNA repair mechanisms and the function of specialized DNA polymerases, particularly in the context of human health and disease. His work investigates how these polymerases interact with DNA structures, such as G-quadruplexes, and how they contribute to processes like translesion DNA synthesis. Ketkar has examined the role of specific protein motifs, like the insert-2 region in human Rev1, in mediating selective binding to these DNA structures and promoting accurate replication. His research also explores the implications of DNA polymerase activity in cancer, specifically in glioblastoma, by investigating how these enzymes act as barriers to replication or influence genomic instability. Ketkar has published findings on the inhibition of key enzymes, such as tryptophan 2,3-dioxygenase, and their impact on DNA damage tolerance and repair in glioma cells. His scholarship metrics include an h-index of 19 with 42 total publications and 826 total citations.
Metrics
- h-index: 19
- Publications: 42
- Citations: 837
Selected Publications
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Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis (2023)
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Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M<sub>1</sub>dG, the Genomic Metabolite of M<sub>1</sub>dG, and Liquid Chromatography–Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι (2021)
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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK (2021)
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Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells (2021)
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Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes (2021)
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DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021)
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Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs (2021)
Grants & Funding
- Translesion DNA polymerase kappa activity in gliomas NIH Co-Investigator
- Replication of G-quadruplex DNA by translesion polymerases National Science Foundation Co-Investigator
Collaboration Network
Top Collaborators
Robert L. Eoff
University of Arkansas for Medical Sciences
8 shared publications
In database
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M<sub>1</sub>dG, the Genomic Metabolite of M<sub>1</sub>dG, and Liquid Chromatography–Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
Showing 5 of 8 shared publications
Leena Maddukuri
University of Arkansas for Medical Sciences
5 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Megan R. Reed
University of Arkansas for Medical Sciences
5 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Justin Leung
University of Arkansas for Medical Sciences (US)
4 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Julie Gunderson
Conway School of Landscape Design
3 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Lane Smith
University of Arkansas for Medical Sciences
2 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Callie Johnson
National Park College (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Alyssa Richey
National Park College (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Makayla Berry
University of Arkansas for Medical Sciences (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Jessica H. Hartman
Medical University of South Carolina (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Maroof K. Zafar
University of Arkansas for Medical Sciences
2 shared publications
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Stephanie D. Byrum
Arkansas Children's Hospital
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
April C.L. Bostian
University of Arkansas for Medical Sciences
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Alan J. Tackett
Arkansas Children's Hospital
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Analiz Rodriguez
University of Arkansas for Medical Sciences
1 shared publication
In database
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Similar Researchers
Based on overlapping research topics
Robert Eoff
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