Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
A
Amit D. Ketkar
Instructor
Also affiliated: University of Arkansas System (2016); Rutgers Health (2011); Rutgers New Jersey Medical School (2008–2011); Indian Institute of Science Bangalore (2004–2005)
Biochemistry & Molecular Biology, College of Medicine
19 h-index
44 pubs
866 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Amit Ketkar's research focuses on DNA repair mechanisms and the function of specialized DNA polymerases, particularly in the context of human health and disease. His work investigates how these polymerases interact with DNA structures, such as G-quadruplexes, and how they contribute to processes like translesion DNA synthesis. Ketkar has examined the role of specific protein motifs, like the insert-2 region in human Rev1, in mediating selective binding to these DNA structures and promoting accurate replication. His research also explores the implications of DNA polymerase activity in cancer, specifically in glioblastoma, by investigating how these enzymes act as barriers to replication or influence genomic instability. Ketkar has published findings on the inhibition of key enzymes, such as tryptophan 2,3-dioxygenase, and their impact on DNA damage tolerance and repair in glioma cells. His scholarship metrics include an h-index of 19 with 42 total publications and 826 total citations.
Metrics
- h-index: 19
- Publications: 44
- Citations: 866
Positions
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Instructor publications 2012–2026University of Arkansas for Medical Sciences Biochemistry & Molecular Biology, College of Medicine Institutional directory
Selected Publications
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Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA (2026)
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Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis (2023)
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Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M1dG, the Genomic Metabolite of M1dG, and Liquid Chromatography–Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι (2021)
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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK (2021)
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Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells (2021)
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Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes (2021)
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DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021)
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Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs (2021)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2020)
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Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms (2019)
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A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells (2018)
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Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents (2018)
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A Novel Small Molecule Inhibitor of Human DNA Polymerase Eta Modulates the Efficacy of Cisplatin in Cancer Cells (2017)
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Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA (2017)
Grants & Funding
As listed on this researcher's institutional profile.
- Translesion DNA polymerase kappa activity in gliomas NIH Co-Investigator
- Replication of G-quadruplex DNA by translesion polymerases National Science Foundation Co-Investigator
Collaboration Network
Top Collaborators
Robert L. Eoff
University of Arkansas for Medical Sciences
35 shared publications
In database
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Kinetic Analysis of Human PrimPol DNA Polymerase Activity Reveals a Generally Error-Prone Enzyme Capable of Accurately Bypassing 7,8-Dihydro-8-oxo-2′-deoxyguanosine
- Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
Showing 5 of 35 shared publications
Leena Maddukuri
University of Arkansas for Medical Sciences
20 shared publications
In database
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
Showing 5 of 20 shared publications
Maroof K. Zafar
University of Arkansas for Medical Sciences
18 shared publications
In database
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Kinetic Analysis of Human PrimPol DNA Polymerase Activity Reveals a Generally Error-Prone Enzyme Capable of Accurately Bypassing 7,8-Dihydro-8-oxo-2′-deoxyguanosine
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
Showing 5 of 18 shared publications
Peter A. Crooks
University of Arkansas for Medical Sciences
13 shared publications
In database
- Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1)
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
Showing 5 of 13 shared publications
Sarah Eddy
University of Arkansas for Medical Sciences (US)
10 shared publications
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
Showing 5 of 10 shared publications
Narsimha Reddy Penthala
University of Arkansas for Medical Sciences
9 shared publications
In database
- Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1)
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
Showing 5 of 9 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
9 shared publications
In database
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Showing 5 of 9 shared publications
Nikhil Reddy Madadi
University of Arkansas for Medical Sciences (US)
5 shared publications
- Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents
- Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells
- Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents
Justin Leung
University of Arkansas for Medical Sciences (US)
4 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Surajit Banerjee
Argonne National Laboratory (US)
3 shared publications
- Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity
- A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota
- Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide Analogues
Martin Egli
Vanderbilt University (US)
3 shared publications
- Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity
- A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota
- Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide Analogues
Mónica L. Guzmán
Cornell University (US)
3 shared publications
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents
- Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents
Jessica H. Hartman
Medical University of South Carolina (US)
3 shared publications
- N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
April C.L. Bostian
University of Arkansas for Medical Sciences
3 shared publications
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Julie Gunderson
Hendrix College
3 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
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