Syed F. Ali
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Also affiliated: Bluefield State College (2022); Meharry Medical College (1998–2007); Cedars-Sinai Medical Center (2022); Brigham and Women's Hospital (2013–2015); MedStar Washington Hospital Center (2022); United States Department of Health and Human Services (2016); National Institutes of Health (1998); Environmental Protection Agency (1998); Beth Israel Deaconess Medical Center (2014); United States Food and Drug Administration (1989–2022); Westchester Medical Center (2023–2024); National Institute on Drug Abuse (1998); St. George's University (2018); Harvard University (1998–2018); University of Kentucky (2014); University of Miami (1998); FMC (United States) (1992–2007); Madurai Medical College (2022); Jinan University (2012); University of California, Los Angeles (2013–2015); University of Calgary (2013–2015); Duke University (2015); Iowa State University (2006); New York Medical College (2023); Dalian Medical University (2004); University of Saint Joseph (2024); National Institute for Occupational Safety and Health (1998); Princeton University (1995); University of California, Irvine (1995); University of Utah (2018); Augusta University (2018); University of Arkansas Medical Center (2014); Ronald Reagan UCLA Medical Center (2015); VA Boston Healthcare System (2013); Centre Hospitalier Universitaire Vaudois (2014); University of California San Diego (2004–2020); Massachusetts General Hospital (1998–2018); National Institute of Environmental Health Sciences (1983–1984); Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (2011); Chevron (United States) (1996–1998); München Klinik (2018); Pitié-Salpêtrière Hospital (2014); Duke Medical Center (2013–2014); Kokilaben Dhirubhai Ambani Hospital (2014); Instituto Nacional de Neurología y Neurocirugía (2001); National Institute for Research and Development of Isotopic and Molecular Technologies (2010); Phoenixville Hospital (2022); National Research Council Canada (1986); Royal Devon University Healthcare NHS Foundation Trust (2025); Hotchkiss Brain Institute (2013–2015); Université Pierre-et-Marie-Curie (2014); University of Regensburg (2018); Drexel University (2022); University of Pennsylvania (2013); Florida Agricultural and Mechanical University (1997); Michigan State University (2013–2015); Texas A&M University (1995)
Research Areas
Biomedical Subjects
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Biography and Research Information
OverviewAI-generated summary
Syed F. Ali's research centers on neurotoxicology and the effects of various substances and materials on the nervous system. He has investigated the impact of nanomaterials, such as silver and manganese nanoparticles, on neural cells, examining mechanisms like dopamine depletion and blood-brain barrier inflammation. His work also includes studying the neurotoxic effects of drugs, including methamphetamine, and factors influencing these effects, such as environmental temperature and gender.
His research has explored gene expression related to oxidative stress in the brain following exposure to nanoparticles. Additionally, Ali has contributed to studies on acute ischemic stroke, analyzing patient characteristics and treatment trends. His scholarship metrics include an h-index of 76, with 587 publications and over 21,000 citations, designating him as a highly cited researcher. He has collaborated with researchers at the University of Arkansas at Fayetteville, including Kartik Balachandran, Jeffrey C. Wolchok, Celeste Dunn, and Sara M. Venier.
Metrics
- h-index: 76
- Publications: 556
- Citations: 20,903
Selected Publications
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Retraction notice to “On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression” [Neurotoxicology and Teratology 33 (2011) 288–296] (2025)
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Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] (2024)
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The Endocannabinoid System in the Central Nervous System: Emphasis on the Role of the Mitochondrial Cannabinoid Receptor 1 (mtCB1R) (2022)
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Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i> (2022)
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Autophagy and protein aggregation as a mechanism of dopaminergic degeneration in a primary human dopaminergic neuronal model (2022)
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Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury (2021)
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The Endocannabinoid System in the Central Nervous System: Emphasis on the Role of the Mitochondrial Cannabinoid Receptor 1 (mtCB1R) (2021)
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Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature (2021)
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Neurotoxicity of thallium: Old issues and new developments (2021)
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Amyloid Beta 25–35 induces blood-brain barrier disruption in vitro (2019)
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Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model (2017)
Collaboration Network
Top Collaborators
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Fetal and adolescent nicotine administration: effects on CNS serotonergic systems
- Age‐related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain
- Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts
Showing 5 of 34 shared publications
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Mechanistic Toxicity Evaluation of Uncoated and PEGylated Single-Walled Carbon Nanotubes in Neuronal PC12 Cells
- Ketamine-Induced Neurotoxicity and Changes in Gene Expression in the Developing Rat Brain
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC)
Showing 5 of 29 shared publications
- Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease
- Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts
- Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic toxicity and peroxynitrite generation
- Role of nitric oxide in rotenone‐induced nigro‐striatal injury
- Peroxynitrite plays a role in methamphetamine‐induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper–zinc superoxide dismutase
Showing 5 of 20 shared publications
- Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles☆
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
- Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts
Showing 5 of 20 shared publications
- The Neuronal Nitric Oxide Synthase Inhibitor, 7‐Nitroindazole, Protects Against Methamphetamine‐Induced Neurotoxicity In Vivo
- Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts
- Peroxynitrite plays a role in methamphetamine‐induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper–zinc superoxide dismutase
- Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization
- Role of nitrergic system in behavioral and neurotoxic effects of amphetamine analogs
Showing 5 of 17 shared publications
- Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of l ‐carnitine
- Protective effects of the antioxidant selenium on quinolinic acid‐induced neurotoxicity in rats:in vitroandin vivostudies
- On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update
- Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington’s disease in rats: Protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III)
- RETRACTED: S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: Involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades
Showing 5 of 16 shared publications
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Developmental toxicity assay using high content screening of zebrafish embryos
- Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish
- Amyloid Beta 25–35 induces blood-brain barrier disruption in vitro
- Acetyl l-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos
Showing 5 of 16 shared publications
- The Interaction of Manganese Nanoparticles with PC-12 Cells Induces Dopamine Depletion
- Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles☆
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Copper nanoparticles exert size and concentration dependent toxicity on somatosensory neurons of rat
- Influence of Nanoparticles on Blood–Brain Barrier Permeability and Brain Edema Formation in Rats
Showing 5 of 14 shared publications
- Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!
- Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of l ‐carnitine
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson’s Disease Model
- The Protective Role of l‐Carnitine against Neurotoxicity Evoked by Drug of Abuse, Methamphetamine, Could Be Related to Mitochondrial Dysfunction
Showing 5 of 14 shared publications
- Cytotoxicity Effects of Graphene and Single-Wall Carbon Nanotubes in Neural Phaeochromocytoma-Derived PC12 Cells
- Mechanistic Toxicity Evaluation of Uncoated and PEGylated Single-Walled Carbon Nanotubes in Neuronal PC12 Cells
- Toxicity and efficacy of carbon nanotubes and graphene: the utility of carbon-based nanoparticles in nanomedicine
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Silver nanoparticle‐induced mutations and oxidative stress in mouse lymphoma cells
Showing 5 of 13 shared publications
- Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts
- MPTP‐induced oxidative stress and neurotoxicity are age‐dependent: Evidence from measures of reactive oxygen species and striatal dopamine levels
- Peroxynitrite plays a role in methamphetamine‐induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper–zinc superoxide dismutase
- Superoxide radicals mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): Evidence from using CuZn‐superoxide dismutase transgenic mice
- Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ
Showing 5 of 11 shared publications
- Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles☆
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase
Showing 5 of 10 shared publications
- The Interaction of Manganese Nanoparticles with PC-12 Cells Induces Dopamine Depletion
- Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
- Manganese-induced reactive oxygen species: Comparison between Mn+2 and Mn+3
- Mercuric chloride-induced reactive oxygen species and its effect on antioxidant enzymes in different regions of rat brain
- Behavioral and neurochemical effects of prenatal methylenedioxymethamphetamine (MDMA) exposure in rats
Showing 5 of 9 shared publications
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- “Isolation stress” revisited: Isolation-rearing effects depend on animal care methods
- Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate
- Ontogeny of the enhanced behavioral response to amphetamine in amphetamine-pretreated rats
- Behavioral and neurochemical effects of prenatal methylenedioxymethamphetamine (MDMA) exposure in rats
Showing 5 of 9 shared publications
- Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!
- The Protective Role of l‐Carnitine against Neurotoxicity Evoked by Drug of Abuse, Methamphetamine, Could Be Related to Mitochondrial Dysfunction
- Possible Mechanism for the Neuroprotective Effects of l‐Carnitine on Methamphetamine‐Evoked Neurotoxicity
- The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions
- l-Carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture
Showing 5 of 9 shared publications
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